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1) NGF (nerve growth factor)(シンポジウム Growth Factorの基礎と臨床, 第434回新潟医学会)
http://hdl.handle.net/10191/41255
http://hdl.handle.net/10191/41255e4eccd47-49a6-4fe6-906a-be003ff96b46
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
103(5)_337-345.pdf (4.2 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-04-11 | |||||
| タイトル | ||||||
| タイトル | 1) NGF (nerve growth factor)(シンポジウム Growth Factorの基礎と臨床, 第434回新潟医学会) | |||||
| タイトル | ||||||
| タイトル | 1) NGF (nerve growth factor)(シンポジウム Growth Factorの基礎と臨床, 第434回新潟医学会) | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | nerve growth factor | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | PC12h | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | differentiation | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | IGF-II | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 神経成長因子 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 分化 | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 著者 |
鈴木, 利光
× 鈴木, 利光 |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 138461 | |||||
| 姓名 | Suzuki, Toshimitsu | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Nerve growth factor (NGF), of which activity had been found 40 years ago, is a typical and classical growth factor, and has been extensively studied by Rita Levi-Montalcini and her co-workers. In this symposium, we reviewed briefly tissue distribution and physiological action of NGF, and NGF-sensitive cell populations. We also described the experiments with use of PC 12h, a rat pheochromocytoma cell line which responds to not only NGF but also dbcAMP. Comparative study revealed that both agents induced morphological differentiation of PC 12h by different ways which included rapid (dbcAMP) and delayed (NGF) induction of neurite outgrowth, and difference in frequency of differentiated cells induced. Moreover, NGF did dramatically increase in the immunoreactivity of insulin-like growth factor (IGF)-II in PC 12h, whereas dbcAMP did not. This result indicated that NGF might induce morphological differentiation of PC 12h through the IGF-II produced by PC 12h under NGF-stimulation, since the IGF-II but not the NGF has been reported to augment the level of tubulin mRNAs in a human neuroblastoma cell line prior to occurrence of neurite outgrowth. | |||||
| 書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 103, 号 5, p. 337-345, 発行日 1989-05 |
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| 出版者 | ||||||
| 出版者 | 新潟医学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00290440 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00182415 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
