@article{oai:niigata-u.repo.nii.ac.jp:00022907,
 author = {鈴木, 利光},
 issue = {5},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {May},
 note = {Nerve growth factor (NGF), of which activity had been found 40 years ago, is a typical and classical growth factor, and has been extensively studied by Rita Levi-Montalcini and her co-workers. In this symposium, we reviewed briefly tissue distribution and physiological action of NGF, and NGF-sensitive cell populations. We also described the experiments with use of PC 12h, a rat pheochromocytoma cell line which responds to not only NGF but also dbcAMP. Comparative study revealed that both agents induced morphological differentiation of PC 12h by different ways which included rapid (dbcAMP) and delayed (NGF) induction of neurite outgrowth, and difference in frequency of differentiated cells induced. Moreover, NGF did dramatically increase in the immunoreactivity of insulin-like growth factor (IGF)-II in PC 12h, whereas dbcAMP did not. This result indicated that NGF might induce morphological differentiation of PC 12h through the IGF-II produced by PC 12h under NGF-stimulation, since the IGF-II but not the NGF has been reported to augment the level of tubulin mRNAs in a human neuroblastoma cell line prior to occurrence of neurite outgrowth.},
 pages = {337--345},
 title = {1) NGF (nerve growth factor)(シンポジウム Growth Factorの基礎と臨床, 第434回新潟医学会)},
 volume = {103},
 year = {1989}
}