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2) HLAによるヒト免疫応答の個体差の決定(シンポジウム 免疫遺伝学の最近の話題, 第463回新潟医学会)
http://hdl.handle.net/10191/39291
http://hdl.handle.net/10191/39291e42aa03a-e4e0-4dd2-ac94-a5b783ae8041
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2016-03-10 | |||||
タイトル | ||||||
タイトル | 2) HLAによるヒト免疫応答の個体差の決定(シンポジウム 免疫遺伝学の最近の話題, 第463回新潟医学会) | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | 2) HLAによるヒト免疫応答の個体差の決定(シンポジウム 免疫遺伝学の最近の話題, 第463回新潟医学会) | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Immunogenetics | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Immune suppression | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Antigen presentation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Streptococcal antigen | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 免疫遺伝 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 免疫抑制 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 抗原提示 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 溶連菌抗原 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | Regulation of Immune Response by HLA Genes(Topics of lmmunogenetics) | |||||
著者 |
西村, 泰治
× 西村, 泰治 |
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著者別名 | ||||||
識別子 | 130682 | |||||
識別子Scheme | WEKO | |||||
姓名 | Nishimura, Yasuharu | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The particular alleles of HLA-DQ locus may control the low immune response to natural antigens by a dominant genetic trait through the immune suppression mediated by CD8+ suppressor T cells. The suppressor T cells may be activated by DQ restricted and antigen specific CD4+ suppressor inducer T cells, because 1) A statistically significant association and linkage between low immune responsiveness to the natural antigens and HLA-DQ gene were observed. 2) Antigen specific CD4+ T cells restricted by the DQ molecules encoded for by the low responder type HLA-DQ allele were evidenced in low but not in high responders. and 3) Anti-HLA-DQ mAb restored the immune response to natural antigens, in some low responders. This HLA-DQ controlled polymorphism of immune response to the natural antigens may account for the association between HLA-DQ alleles and organ specific autoimmune diseases. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 105, 号 7, p. 438-445, 発行日 1991-07 |
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出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |