{"_buckets": {"deposit": "6aa0e969-5946-4409-837e-fb2f1ff76670"}, "_deposit": {"id": "21352", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "21352"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00021352"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "Regulation of Immune Response by HLA Genes(Topics of lmmunogenetics)"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1991-07", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "7", "bibliographicPageEnd": "445", "bibliographicPageStart": "438", "bibliographicVolumeNumber": "105", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c"}, {"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "The particular alleles of HLA-DQ locus may control the low immune response to natural antigens by a dominant genetic trait through the immune suppression mediated by CD8+ suppressor T cells. The suppressor T cells may be activated by DQ restricted and antigen specific CD4+ suppressor inducer T cells, because 1) A statistically significant association and linkage between low immune responsiveness to the natural antigens and HLA-DQ gene were observed. 2) Antigen specific CD4+ T cells restricted by the DQ molecules encoded for by the low responder type HLA-DQ allele were evidenced in low but not in high responders. and 3) Anti-HLA-DQ mAb restored the immune response to natural antigens, in some low responders. This HLA-DQ controlled polymorphism of immune response to the natural antigens may account for the association between HLA-DQ alleles and organ specific autoimmune diseases.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "130682", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Nishimura, Yasuharu"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u897f\u6751, \u6cf0\u6cbb"}], "nameIdentifiers": [{"nameIdentifier": "130681", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-16"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "105(7)_438-445.pdf", "filesize": [{"value": "1.7 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1700000.0, "url": {"label": "105(7)_438-445.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/21352/files/105(7)_438-445.pdf"}, "version_id": "22b21c5d-5df3-4b1a-bc1f-ae6bd44766d2"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Immunogenetics", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Immune suppression", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Antigen presentation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Streptococcal antigen", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u514d\u75ab\u907a\u4f1d", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u514d\u75ab\u6291\u5236", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u6297\u539f\u63d0\u793a", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u6eb6\u9023\u83cc\u6297\u539f", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "2) HLA\u306b\u3088\u308b\u30d2\u30c8\u514d\u75ab\u5fdc\u7b54\u306e\u500b\u4f53\u5dee\u306e\u6c7a\u5b9a(\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 \u514d\u75ab\u907a\u4f1d\u5b66\u306e\u6700\u8fd1\u306e\u8a71\u984c, \u7b2c463\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a)", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "2) HLA\u306b\u3088\u308b\u30d2\u30c8\u514d\u75ab\u5fdc\u7b54\u306e\u500b\u4f53\u5dee\u306e\u6c7a\u5b9a(\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 \u514d\u75ab\u907a\u4f1d\u5b66\u306e\u6700\u8fd1\u306e\u8a71\u984c, \u7b2c463\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a)"}, {"subitem_title": "2) HLA\u306b\u3088\u308b\u30d2\u30c8\u514d\u75ab\u5fdc\u7b54\u306e\u500b\u4f53\u5dee\u306e\u6c7a\u5b9a(\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 \u514d\u75ab\u907a\u4f1d\u5b66\u306e\u6700\u8fd1\u306e\u8a71\u984c, \u7b2c463\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a)", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/1184"], "permalink_uri": "http://hdl.handle.net/10191/39291", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2016-03-10"}, "publish_date": "2016-03-10", "publish_status": "0", "recid": "21352", "relation": {}, "relation_version_is_last": true, "title": ["2) HLA\u306b\u3088\u308b\u30d2\u30c8\u514d\u75ab\u5fdc\u7b54\u306e\u500b\u4f53\u5dee\u306e\u6c7a\u5b9a(\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 \u514d\u75ab\u907a\u4f1d\u5b66\u306e\u6700\u8fd1\u306e\u8a71\u984c, \u7b2c463\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a)"], "weko_shared_id": null}