{"created":"2021-03-01T06:26:23.593450+00:00","id":21352,"links":{},"metadata":{"_buckets":{"deposit":"6aa0e969-5946-4409-837e-fb2f1ff76670"},"_deposit":{"id":"21352","owners":[],"pid":{"revision_id":0,"type":"depid","value":"21352"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00021352","sets":["453:456","471:537:538:1184"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Regulation of Immune Response by HLA Genes(Topics of lmmunogenetics)"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1991-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"445","bibliographicPageStart":"438","bibliographicVolumeNumber":"105","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The particular alleles of HLA-DQ locus may control the low immune response to natural antigens by a dominant genetic trait through the immune suppression mediated by CD8+ suppressor T cells. The suppressor T cells may be activated by DQ restricted and antigen specific CD4+ suppressor inducer T cells, because 1) A statistically significant association and linkage between low immune responsiveness to the natural antigens and HLA-DQ gene were observed. 2) Antigen specific CD4+ T cells restricted by the DQ molecules encoded for by the low responder type HLA-DQ allele were evidenced in low but not in high responders. and 3) Anti-HLA-DQ mAb restored the immune response to natural antigens, in some low responders. This HLA-DQ controlled polymorphism of immune response to the natural antigens may account for the association between HLA-DQ alleles and organ specific autoimmune diseases.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"130682","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Nishimura, Yasuharu"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"西村, 泰治"}],"nameIdentifiers":[{"nameIdentifier":"130681","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-16"}],"displaytype":"detail","filename":"105(7)_438-445.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"105(7)_438-445.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/21352/files/105(7)_438-445.pdf"},"version_id":"22b21c5d-5df3-4b1a-bc1f-ae6bd44766d2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Immunogenetics","subitem_subject_scheme":"Other"},{"subitem_subject":"Immune suppression","subitem_subject_scheme":"Other"},{"subitem_subject":"Antigen presentation","subitem_subject_scheme":"Other"},{"subitem_subject":"Streptococcal antigen","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫遺伝","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫抑制","subitem_subject_scheme":"Other"},{"subitem_subject":"抗原提示","subitem_subject_scheme":"Other"},{"subitem_subject":"溶連菌抗原","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"2) HLAによるヒト免疫応答の個体差の決定(シンポジウム 免疫遺伝学の最近の話題, 第463回新潟医学会)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"2) HLAによるヒト免疫応答の個体差の決定(シンポジウム 免疫遺伝学の最近の話題, 第463回新潟医学会)"},{"subitem_title":"2) HLAによるヒト免疫応答の個体差の決定(シンポジウム 免疫遺伝学の最近の話題, 第463回新潟医学会)","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1184"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-03-10"},"publish_date":"2016-03-10","publish_status":"0","recid":"21352","relation_version_is_last":true,"title":["2) HLAによるヒト免疫応答の個体差の決定(シンポジウム 免疫遺伝学の最近の話題, 第463回新潟医学会)"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:51:53.932658+00:00"}