@article{oai:niigata-u.repo.nii.ac.jp:00021352, author = {西村, 泰治}, issue = {7}, journal = {新潟医学会雑誌, 新潟医学会雑誌}, month = {Jul}, note = {The particular alleles of HLA-DQ locus may control the low immune response to natural antigens by a dominant genetic trait through the immune suppression mediated by CD8+ suppressor T cells. The suppressor T cells may be activated by DQ restricted and antigen specific CD4+ suppressor inducer T cells, because 1) A statistically significant association and linkage between low immune responsiveness to the natural antigens and HLA-DQ gene were observed. 2) Antigen specific CD4+ T cells restricted by the DQ molecules encoded for by the low responder type HLA-DQ allele were evidenced in low but not in high responders. and 3) Anti-HLA-DQ mAb restored the immune response to natural antigens, in some low responders. This HLA-DQ controlled polymorphism of immune response to the natural antigens may account for the association between HLA-DQ alleles and organ specific autoimmune diseases.}, pages = {438--445}, title = {2) HLAによるヒト免疫応答の個体差の決定(シンポジウム 免疫遺伝学の最近の話題, 第463回新潟医学会)}, volume = {105}, year = {1991} }