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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第105巻第8号

実験的脳梗塞における脳蛋白質の変化とプロテアーゼインヒビターの効果に関する研究

http://hdl.handle.net/10191/39333
http://hdl.handle.net/10191/39333
8e91f3dd-4513-460b-b851-886be690f5ee
名前 / ファイル ライセンス アクション
105(8)_548-553.pdf 105(8)_548-553.pdf (1.4 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2016-03-10
タイトル
タイトル 実験的脳梗塞における脳蛋白質の変化とプロテアーゼインヒビターの効果に関する研究
タイトル
言語 en
タイトル 実験的脳梗塞における脳蛋白質の変化とプロテアーゼインヒビターの効果に関する研究
言語
言語 jpn
キーワード
主題Scheme Other
主題 focal cerebral ischemia
キーワード
主題Scheme Other
主題 protein
キーワード
主題Scheme Other
主題 calpain E-64c
キーワード
主題Scheme Other
主題 microtubule-associated protein 2
キーワード
主題Scheme Other
主題 局所脳虚血
キーワード
主題Scheme Other
主題 蛋白
キーワード
主題Scheme Other
主題 カルシウム依存性中性プロテアーゼ
キーワード
主題Scheme Other
主題 E-64
キーワード
主題Scheme Other
主題 微小管関連蛋白
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Degradation of Cerebral Proteins and Effects of Protease Inhibitor in Experimental Cerebral Infarction
著者 犬塚, 貴

× 犬塚, 貴

WEKO 130357

犬塚, 貴

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著者別名
識別子 130358
識別子Scheme WEKO
姓名 Inuzuka, Takashi
抄録
内容記述タイプ Abstract
内容記述 Using an immunoblotting technique, I investigated changes in the concentrations of microtubule-associated protein 2 (MAP 2), 200kD neurofilament, tubulin, myelin-associated glycoprotein (MAG) and 2':3'-cyclic nucleotide 3'-phosphodiesterase in the rats brains following occlusion of the left middle cerebral artery or sham operation. Compared with those 4 hours after surgery, concentrations of all proteins decreased significantly in the left hemisphere 3 days after surgery (p<0.01). Microtubule-associated protein 2 was the most susceptible to ischemia. Degradation products of MAP 2 and MAG were detected on the blots. Furthermore, in the contralateral himisphere, concentrations of these two proteins decreased comparing with those in concurrent sham-operated controls 3 days after surgery. Changes in the concentrations of cerebral proteins in the contralateral hemisphere are important for understanding clinical symptoms not attributable solely to the ipsilateral lesion following a focal cerebral stroke. Since MAP 2 is one of the substrate of calpain, E-64c, a synthetic calpain inhibitor, was administered at a dose of 400mg/kg twice a day for 3 days, with the first dose being given before the production of ischemia. The depletion of MAP 2 was significantly inhibited in vivo by E-64c (p<0.05). The results suggest that calpain is partially involved in the degradation of MAP 2, and that the use of calpain inhibitors can be a useful clinical approach to cerebral ischemia.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 105, 号 8, p. 548-553, 発行日 1991-08
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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