{"_buckets": {"deposit": "d9c792c9-1505-47cf-b139-cb00066b0ecf"}, "_deposit": {"id": "21292", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "21292"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00021292"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "Degradation of Cerebral Proteins and Effects of Protease Inhibitor in Experimental Cerebral Infarction"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1991-08", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "8", "bibliographicPageEnd": "553", "bibliographicPageStart": "548", "bibliographicVolumeNumber": "105", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c"}, {"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Using an immunoblotting technique, I investigated changes in the concentrations of microtubule-associated protein 2 (MAP 2), 200kD neurofilament, tubulin, myelin-associated glycoprotein (MAG) and 2\u0027:3\u0027-cyclic nucleotide 3\u0027-phosphodiesterase in the rats brains following occlusion of the left middle cerebral artery or sham operation. Compared with those 4 hours after surgery, concentrations of all proteins decreased significantly in the left hemisphere 3 days after surgery (p\u003c0.01). Microtubule-associated protein 2 was the most susceptible to ischemia. Degradation products of MAP 2 and MAG were detected on the blots. Furthermore, in the contralateral himisphere, concentrations of these two proteins decreased comparing with those in concurrent sham-operated controls 3 days after surgery. Changes in the concentrations of cerebral proteins in the contralateral hemisphere are important for understanding clinical symptoms not attributable solely to the ipsilateral lesion following a focal cerebral stroke. Since MAP 2 is one of the substrate of calpain, E-64c, a synthetic calpain inhibitor, was administered at a dose of 400mg/kg twice a day for 3 days, with the first dose being given before the production of ischemia. The depletion of MAP 2 was significantly inhibited in vivo by E-64c (p\u003c0.05). The results suggest that calpain is partially involved in the degradation of MAP 2, and that the use of calpain inhibitors can be a useful clinical approach to cerebral ischemia.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "130358", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Inuzuka, Takashi"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u72ac\u585a, \u8cb4"}], "nameIdentifiers": [{"nameIdentifier": "130357", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-16"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "105(8)_548-553.pdf", "filesize": [{"value": "1.4 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1400000.0, "url": {"label": "105(8)_548-553.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/21292/files/105(8)_548-553.pdf"}, "version_id": "b519c8eb-dcc7-4e0b-abeb-a4c65eafb2dc"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "focal cerebral ischemia", "subitem_subject_scheme": "Other"}, {"subitem_subject": "protein", "subitem_subject_scheme": "Other"}, {"subitem_subject": "calpain E-64c", "subitem_subject_scheme": "Other"}, {"subitem_subject": "microtubule-associated protein 2", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u5c40\u6240\u8133\u865a\u8840", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u86cb\u767d", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30ab\u30eb\u30b7\u30a6\u30e0\u4f9d\u5b58\u6027\u4e2d\u6027\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc", "subitem_subject_scheme": "Other"}, {"subitem_subject": "E-64", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u5fae\u5c0f\u7ba1\u95a2\u9023\u86cb\u767d", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "\u5b9f\u9a13\u7684\u8133\u6897\u585e\u306b\u304a\u3051\u308b\u8133\u86cb\u767d\u8cea\u306e\u5909\u5316\u3068\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u30a4\u30f3\u30d2\u30d3\u30bf\u30fc\u306e\u52b9\u679c\u306b\u95a2\u3059\u308b\u7814\u7a76", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "\u5b9f\u9a13\u7684\u8133\u6897\u585e\u306b\u304a\u3051\u308b\u8133\u86cb\u767d\u8cea\u306e\u5909\u5316\u3068\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u30a4\u30f3\u30d2\u30d3\u30bf\u30fc\u306e\u52b9\u679c\u306b\u95a2\u3059\u308b\u7814\u7a76"}, {"subitem_title": "\u5b9f\u9a13\u7684\u8133\u6897\u585e\u306b\u304a\u3051\u308b\u8133\u86cb\u767d\u8cea\u306e\u5909\u5316\u3068\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u30a4\u30f3\u30d2\u30d3\u30bf\u30fc\u306e\u52b9\u679c\u306b\u95a2\u3059\u308b\u7814\u7a76", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/1183"], "permalink_uri": "http://hdl.handle.net/10191/39333", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2016-03-10"}, "publish_date": "2016-03-10", "publish_status": "0", "recid": "21292", "relation": {}, "relation_version_is_last": true, "title": ["\u5b9f\u9a13\u7684\u8133\u6897\u585e\u306b\u304a\u3051\u308b\u8133\u86cb\u767d\u8cea\u306e\u5909\u5316\u3068\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u30a4\u30f3\u30d2\u30d3\u30bf\u30fc\u306e\u52b9\u679c\u306b\u95a2\u3059\u308b\u7814\u7a76"], "weko_shared_id": null}