{"_buckets": {"deposit": "d9c792c9-1505-47cf-b139-cb00066b0ecf"}, "_deposit": {"id": "21292", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "21292"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00021292", "sets": ["456", "1183"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Degradation of Cerebral Proteins and Effects of Protease Inhibitor in Experimental Cerebral Infarction"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1991-08", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "8", "bibliographicPageEnd": "553", "bibliographicPageStart": "548", "bibliographicVolumeNumber": "105", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Using an immunoblotting technique, I investigated changes in the concentrations of microtubule-associated protein 2 (MAP 2), 200kD neurofilament, tubulin, myelin-associated glycoprotein (MAG) and 2\u0027:3\u0027-cyclic nucleotide 3\u0027-phosphodiesterase in the rats brains following occlusion of the left middle cerebral artery or sham operation. Compared with those 4 hours after surgery, concentrations of all proteins decreased significantly in the left hemisphere 3 days after surgery (p\u003c0.01). Microtubule-associated protein 2 was the most susceptible to ischemia. Degradation products of MAP 2 and MAG were detected on the blots. Furthermore, in the contralateral himisphere, concentrations of these two proteins decreased comparing with those in concurrent sham-operated controls 3 days after surgery. Changes in the concentrations of cerebral proteins in the contralateral hemisphere are important for understanding clinical symptoms not attributable solely to the ipsilateral lesion following a focal cerebral stroke. Since MAP 2 is one of the substrate of calpain, E-64c, a synthetic calpain inhibitor, was administered at a dose of 400mg/kg twice a day for 3 days, with the first dose being given before the production of ischemia. The depletion of MAP 2 was significantly inhibited in vivo by E-64c (p\u003c0.05). The results suggest that calpain is partially involved in the degradation of MAP 2, and that the use of calpain inhibitors can be a useful clinical approach to cerebral ischemia.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "130358", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Inuzuka, Takashi"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "犬塚, 貴"}], "nameIdentifiers": [{"nameIdentifier": "130357", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-16"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "105(8)_548-553.pdf", "filesize": [{"value": "1.4 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1400000.0, "url": {"label": "105(8)_548-553.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/21292/files/105(8)_548-553.pdf"}, "version_id": "b519c8eb-dcc7-4e0b-abeb-a4c65eafb2dc"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "focal cerebral ischemia", "subitem_subject_scheme": "Other"}, {"subitem_subject": "protein", "subitem_subject_scheme": "Other"}, {"subitem_subject": "calpain E-64c", "subitem_subject_scheme": "Other"}, {"subitem_subject": "microtubule-associated protein 2", "subitem_subject_scheme": "Other"}, {"subitem_subject": "局所脳虚血", "subitem_subject_scheme": "Other"}, {"subitem_subject": "蛋白", "subitem_subject_scheme": "Other"}, {"subitem_subject": "カルシウム依存性中性プロテアーゼ", "subitem_subject_scheme": "Other"}, {"subitem_subject": "E-64", "subitem_subject_scheme": "Other"}, {"subitem_subject": "微小管関連蛋白", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "実験的脳梗塞における脳蛋白質の変化とプロテアーゼインヒビターの効果に関する研究", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "実験的脳梗塞における脳蛋白質の変化とプロテアーゼインヒビターの効果に関する研究"}, {"subitem_title": "実験的脳梗塞における脳蛋白質の変化とプロテアーゼインヒビターの効果に関する研究", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1183"], "permalink_uri": "http://hdl.handle.net/10191/39333", "pubdate": {"attribute_name": "公開日", "attribute_value": "2016-03-10"}, "publish_date": "2016-03-10", "publish_status": "0", "recid": "21292", "relation": {}, "relation_version_is_last": true, "title": ["実験的脳梗塞における脳蛋白質の変化とプロテアーゼインヒビターの効果に関する研究"], "weko_shared_id": null}