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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第105巻第11号

細菌の病原因子と免疫応答

http://hdl.handle.net/10191/39427
http://hdl.handle.net/10191/39427
7082013b-a09a-4e66-a612-f142da550588
名前 / ファイル ライセンス アクション
105(11)_729-734.pdf 105(11)_729-734.pdf (1.2 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2016-03-11
タイトル
タイトル 細菌の病原因子と免疫応答
タイトル
言語 en
タイトル 細菌の病原因子と免疫応答
言語
言語 jpn
キーワード
主題Scheme Other
主題 Listeria monocytogenes
キーワード
主題Scheme Other
主題 bacterial virulence
キーワード
主題Scheme Other
主題 protective immunity
キーワード
主題Scheme Other
主題 リステリア
キーワード
主題Scheme Other
主題 細菌の病原性
キーワード
主題Scheme Other
主題 感染防御免疫
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Relationship Between Virulence Factor of Bacteria and the Immune Response
著者 光山, 正雄

× 光山, 正雄

WEKO 130108

光山, 正雄

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著者別名
識別子 130109
識別子Scheme WEKO
姓名 Mitsuyama, Masao
抄録
内容記述タイプ Abstract
内容記述 Listeria monocytogenes is one of the facultative intracellular bacteria and generates typical cell-mediated immune response in infected host. Among several possible virulence factors, a 58kDa-hemolysin has been regarded as the main factor responsible for intracellular survival of this microbe within macrophages. T cells mediating delayed type hypersensitivity and protective immunity could be generated only when mice were immunized with viable, hemolysin-producing strain of L. monocytogenes. The generation of Listeria-specific protective T cells coincided with the ability of bacteria to induce IL-1 production in macrophages. In vivo administration of recombinant IL-1 promoted the functional differentiation of Listeria-specific T cells even in mice immunized with hemolysin-nonproducing killed bacterial vaccine. The purified 58kDa-hemolysin was shown to induce macrophage IL-1 production in vitro. This is a typical example of direct contribution of virulence factor of bacteria to host immune response. The relationship between other virulence factors and host response was also discussed.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 105, 号 11, p. 729-734, 発行日 1991-11
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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