{"_buckets": {"deposit": "0c07d209-64e6-4709-98ab-d3f948bd6fb4"}, "_deposit": {"id": "21251", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "21251"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00021251", "sets": ["456", "1180"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Relationship Between Virulence Factor of Bacteria and the Immune Response"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1991-11", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "11", "bibliographicPageEnd": "734", "bibliographicPageStart": "729", "bibliographicVolumeNumber": "105", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Listeria monocytogenes is one of the facultative intracellular bacteria and generates typical cell-mediated immune response in infected host. Among several possible virulence factors, a 58kDa-hemolysin has been regarded as the main factor responsible for intracellular survival of this microbe within macrophages. T cells mediating delayed type hypersensitivity and protective immunity could be generated only when mice were immunized with viable, hemolysin-producing strain of L. monocytogenes. The generation of Listeria-specific protective T cells coincided with the ability of bacteria to induce IL-1 production in macrophages. In vivo administration of recombinant IL-1 promoted the functional differentiation of Listeria-specific T cells even in mice immunized with hemolysin-nonproducing killed bacterial vaccine. The purified 58kDa-hemolysin was shown to induce macrophage IL-1 production in vitro. This is a typical example of direct contribution of virulence factor of bacteria to host immune response. The relationship between other virulence factors and host response was also discussed.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "130109", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Mitsuyama, Masao"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "光山, 正雄"}], "nameIdentifiers": [{"nameIdentifier": "130108", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-16"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "105(11)_729-734.pdf", "filesize": [{"value": "1.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1200000.0, "url": {"label": "105(11)_729-734.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/21251/files/105(11)_729-734.pdf"}, "version_id": "e65367f6-f608-40ae-b6b8-1b69e990aa34"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Listeria monocytogenes", "subitem_subject_scheme": "Other"}, {"subitem_subject": "bacterial virulence", "subitem_subject_scheme": "Other"}, {"subitem_subject": "protective immunity", "subitem_subject_scheme": "Other"}, {"subitem_subject": "リステリア", "subitem_subject_scheme": "Other"}, {"subitem_subject": "細菌の病原性", "subitem_subject_scheme": "Other"}, {"subitem_subject": "感染防御免疫", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "細菌の病原因子と免疫応答", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "細菌の病原因子と免疫応答"}, {"subitem_title": "細菌の病原因子と免疫応答", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1180"], "permalink_uri": "http://hdl.handle.net/10191/39427", "pubdate": {"attribute_name": "公開日", "attribute_value": "2016-03-11"}, "publish_date": "2016-03-11", "publish_status": "0", "recid": "21251", "relation": {}, "relation_version_is_last": true, "title": ["細菌の病原因子と免疫応答"], "weko_shared_id": null}