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細菌の病原因子と免疫応答
http://hdl.handle.net/10191/39427
http://hdl.handle.net/10191/394277082013b-a09a-4e66-a612-f142da550588
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2016-03-11 | |||||
タイトル | ||||||
タイトル | 細菌の病原因子と免疫応答 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | 細菌の病原因子と免疫応答 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Listeria monocytogenes | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | bacterial virulence | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | protective immunity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | リステリア | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 細菌の病原性 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 感染防御免疫 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | Relationship Between Virulence Factor of Bacteria and the Immune Response | |||||
著者 |
光山, 正雄
× 光山, 正雄 |
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著者別名 | ||||||
識別子 | 130109 | |||||
識別子Scheme | WEKO | |||||
姓名 | Mitsuyama, Masao | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Listeria monocytogenes is one of the facultative intracellular bacteria and generates typical cell-mediated immune response in infected host. Among several possible virulence factors, a 58kDa-hemolysin has been regarded as the main factor responsible for intracellular survival of this microbe within macrophages. T cells mediating delayed type hypersensitivity and protective immunity could be generated only when mice were immunized with viable, hemolysin-producing strain of L. monocytogenes. The generation of Listeria-specific protective T cells coincided with the ability of bacteria to induce IL-1 production in macrophages. In vivo administration of recombinant IL-1 promoted the functional differentiation of Listeria-specific T cells even in mice immunized with hemolysin-nonproducing killed bacterial vaccine. The purified 58kDa-hemolysin was shown to induce macrophage IL-1 production in vitro. This is a typical example of direct contribution of virulence factor of bacteria to host immune response. The relationship between other virulence factors and host response was also discussed. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 105, 号 11, p. 729-734, 発行日 1991-11 |
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出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |