@article{oai:niigata-u.repo.nii.ac.jp:00021251,
 author = {光山, 正雄},
 issue = {11},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Nov},
 note = {Listeria monocytogenes is one of the facultative intracellular bacteria and generates typical cell-mediated immune response in infected host. Among several possible virulence factors, a 58kDa-hemolysin has been regarded as the main factor responsible for intracellular survival of this microbe within macrophages. T cells mediating delayed type hypersensitivity and protective immunity could be generated only when mice were immunized with viable, hemolysin-producing strain of L. monocytogenes. The generation of Listeria-specific protective T cells coincided with the ability of bacteria to induce IL-1 production in macrophages. In vivo administration of recombinant IL-1 promoted the functional differentiation of Listeria-specific T cells even in mice immunized with hemolysin-nonproducing killed bacterial vaccine. The purified 58kDa-hemolysin was shown to induce macrophage IL-1 production in vitro. This is a typical example of direct contribution of virulence factor of bacteria to host immune response. The relationship between other virulence factors and host response was also discussed.},
 pages = {729--734},
 title = {細菌の病原因子と免疫応答},
 volume = {105},
 year = {1991}
}