{"created":"2021-03-01T06:26:16.999866+00:00","id":21251,"links":{},"metadata":{"_buckets":{"deposit":"0c07d209-64e6-4709-98ab-d3f948bd6fb4"},"_deposit":{"id":"21251","owners":[],"pid":{"revision_id":0,"type":"depid","value":"21251"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00021251","sets":["453:456","471:537:538:1180"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Relationship Between Virulence Factor of Bacteria and the Immune Response"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1991-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"734","bibliographicPageStart":"729","bibliographicVolumeNumber":"105","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Listeria monocytogenes is one of the facultative intracellular bacteria and generates typical cell-mediated immune response in infected host. Among several possible virulence factors, a 58kDa-hemolysin has been regarded as the main factor responsible for intracellular survival of this microbe within macrophages. T cells mediating delayed type hypersensitivity and protective immunity could be generated only when mice were immunized with viable, hemolysin-producing strain of L. monocytogenes. The generation of Listeria-specific protective T cells coincided with the ability of bacteria to induce IL-1 production in macrophages. In vivo administration of recombinant IL-1 promoted the functional differentiation of Listeria-specific T cells even in mice immunized with hemolysin-nonproducing killed bacterial vaccine. The purified 58kDa-hemolysin was shown to induce macrophage IL-1 production in vitro. This is a typical example of direct contribution of virulence factor of bacteria to host immune response. The relationship between other virulence factors and host response was also discussed.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"130109","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Mitsuyama, Masao"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"光山, 正雄"}],"nameIdentifiers":[{"nameIdentifier":"130108","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-16"}],"displaytype":"detail","filename":"105(11)_729-734.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"105(11)_729-734.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/21251/files/105(11)_729-734.pdf"},"version_id":"e65367f6-f608-40ae-b6b8-1b69e990aa34"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Listeria monocytogenes","subitem_subject_scheme":"Other"},{"subitem_subject":"bacterial virulence","subitem_subject_scheme":"Other"},{"subitem_subject":"protective immunity","subitem_subject_scheme":"Other"},{"subitem_subject":"リステリア","subitem_subject_scheme":"Other"},{"subitem_subject":"細菌の病原性","subitem_subject_scheme":"Other"},{"subitem_subject":"感染防御免疫","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"細菌の病原因子と免疫応答","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"細菌の病原因子と免疫応答"},{"subitem_title":"細菌の病原因子と免疫応答","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1180"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-03-11"},"publish_date":"2016-03-11","publish_status":"0","recid":"21251","relation_version_is_last":true,"title":["細菌の病原因子と免疫応答"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:51:45.942625+00:00"}