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4) アルツハイマー病における神経成長抑制因子の分子生物学(シンポジウム 老年痴呆の諸問題, 第468回新潟医学会)
http://hdl.handle.net/10191/37193
http://hdl.handle.net/10191/371937e677e4a-3dc1-4ac1-9a44-66863b722b8b
名前 / ファイル | ライセンス | アクション |
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107(2)_117-123.pdf (1.7 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2016-01-25 | |||||
タイトル | ||||||
タイトル | 4) アルツハイマー病における神経成長抑制因子の分子生物学(シンポジウム 老年痴呆の諸問題, 第468回新潟医学会) | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | 4) アルツハイマー病における神経成長抑制因子の分子生物学(シンポジウム 老年痴呆の諸問題, 第468回新潟医学会) | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Alztheimer's disease | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cDNA | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | growth inhibitory factor (GIF) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | metallothionein | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | transcriptional regulation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | アルツハイマー病 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cDNA | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 神経成長抑制因子 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | メタロチオネイン | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 転写制御 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | Molecular biology of growth inhibitory factor in Alzheimer's disease(Senile Dementia of Alzheimer Type) | |||||
著者 |
辻, 省次
× 辻, 省次× 小林, 央× 宮武, 正 |
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著者別名 | ||||||
識別子 | 125739 | |||||
識別子Scheme | WEKO | |||||
姓名 | Tsuji, Shoji | |||||
著者別名 | ||||||
識別子 | 125740 | |||||
識別子Scheme | WEKO | |||||
姓名 | Kobayashi, Hisashi | |||||
著者別名 | ||||||
識別子 | 125741 | |||||
識別子Scheme | WEKO | |||||
姓名 | Miyatake, Tadashi | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Although the pathophysiology of the formation of senile pleque, a cardinal pathological feature of Alzheimer's disease, is becomming well understood, the mechanisms of neuronal degeneration are still unclear. To better understand the mechanism of neuronal death in Alzheimer's disease, we have undertaken molecular cloning of a cDNA for human growth inhibitory factor (GIF), which has recently been identified as a unique protein with malkedly reduced expression in Alzheimer's disease. Molecular cloning of cDNA for human GIF revealed that the GIF cDNA has a strikingly high homology to human metallothioneins. The tissue distribution of the GIF mRNA expression is exclusively specific to the central nervous system, indicating that the trasncriptional regulation of GIF gene is quite different from those of metallothionein genes despite of it high homology. Furthermore, it was demonstrated that the GIF mRNA expression is markedly reduced in Alzheimer's disease. The data indicate that it is crucially important to elucidate the mechanism of the downregulation of the GIF gene in Alzheimer's disease. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 107, 号 2, p. 117-123, 発行日 1993-02 |
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出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |