{"created":"2021-03-01T06:25:16.689423+00:00","id":20336,"links":{},"metadata":{"_buckets":{"deposit":"33d47976-de90-47c4-b7ac-ef47410d21f8"},"_deposit":{"id":"20336","owners":[],"pid":{"revision_id":0,"type":"depid","value":"20336"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00020336","sets":["453:456","471:537:538:1165"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Molecular biology of growth inhibitory factor in Alzheimer's disease(Senile Dementia of Alzheimer Type)"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1993-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"123","bibliographicPageStart":"117","bibliographicVolumeNumber":"107","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Although the pathophysiology of the formation of senile pleque, a cardinal pathological feature of Alzheimer's disease, is becomming well understood, the mechanisms of neuronal degeneration are still unclear. To better understand the mechanism of neuronal death in Alzheimer's disease, we have undertaken molecular cloning of a cDNA for human growth inhibitory factor (GIF), which has recently been identified as a unique protein with malkedly reduced expression in Alzheimer's disease. Molecular cloning of cDNA for human GIF revealed that the GIF cDNA has a strikingly high homology to human metallothioneins. The tissue distribution of the GIF mRNA expression is exclusively specific to the central nervous system, indicating that the trasncriptional regulation of GIF gene is quite different from those of metallothionein genes despite of it high homology. Furthermore, it was demonstrated that the GIF mRNA expression is markedly reduced in Alzheimer's disease. The data indicate that it is crucially important to elucidate the mechanism of the downregulation of the GIF gene in Alzheimer's disease.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"125739","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Tsuji, Shoji"}]},{"nameIdentifiers":[{"nameIdentifier":"125740","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kobayashi, Hisashi"}]},{"nameIdentifiers":[{"nameIdentifier":"125741","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Miyatake, Tadashi"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"辻, 省次"}],"nameIdentifiers":[{"nameIdentifier":"125736","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小林, 央"}],"nameIdentifiers":[{"nameIdentifier":"125737","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"宮武, 正"}],"nameIdentifiers":[{"nameIdentifier":"125738","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-16"}],"displaytype":"detail","filename":"107(2)_117-123.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"107(2)_117-123.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/20336/files/107(2)_117-123.pdf"},"version_id":"19798818-7ac8-4c62-89ab-3434bfad68be"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Alztheimer's disease","subitem_subject_scheme":"Other"},{"subitem_subject":"cDNA","subitem_subject_scheme":"Other"},{"subitem_subject":"growth inhibitory factor (GIF)","subitem_subject_scheme":"Other"},{"subitem_subject":"metallothionein","subitem_subject_scheme":"Other"},{"subitem_subject":"transcriptional regulation","subitem_subject_scheme":"Other"},{"subitem_subject":"アルツハイマー病","subitem_subject_scheme":"Other"},{"subitem_subject":"cDNA","subitem_subject_scheme":"Other"},{"subitem_subject":"神経成長抑制因子","subitem_subject_scheme":"Other"},{"subitem_subject":"メタロチオネイン","subitem_subject_scheme":"Other"},{"subitem_subject":"転写制御","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"4） アルツハイマー病における神経成長抑制因子の分子生物学(シンポジウム 老年痴呆の諸問題, 第468回新潟医学会)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"4） アルツハイマー病における神経成長抑制因子の分子生物学(シンポジウム 老年痴呆の諸問題, 第468回新潟医学会)"},{"subitem_title":"4） アルツハイマー病における神経成長抑制因子の分子生物学(シンポジウム 老年痴呆の諸問題, 第468回新潟医学会)","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1165"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-01-25"},"publish_date":"2016-01-25","publish_status":"0","recid":"20336","relation_version_is_last":true,"title":["4） アルツハイマー病における神経成長抑制因子の分子生物学(シンポジウム 老年痴呆の諸問題, 第468回新潟医学会)"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:51:09.465772+00:00"}