{"_buckets": {"deposit": "1278cc99-21cf-4de1-b988-54dc49cf51d6"}, "_deposit": {"id": "14962", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "14962"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00014962"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "Proliferative Potential of Acoustic Neurinomas Evaluated by MIB-1 Labeling index"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2001-04", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "155", "bibliographicPageStart": "148", "bibliographicVolumeNumber": "115", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c"}, {"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "The purpose of this study was to assess the proliferative potential, i.e., tumor regrowth of acoustic neurinomas utilizing the monoclonal antibody MIB-1 labeling index (MIB-1 index). MIB-1 index were examined in 121 consecutive patients with unilateral acoustic neurinoma, 47 males and 74 females, ranging in age from 20 to 76 years. Of the 121 patients, 12 (9.9%) had tumor regrowth after the initial surgery, While none of 55 patients whose tumors were totally removed had no tumor regrowth, 12 (18.2%) of the other 66 patients having residual tumors had regrowth of the tumor. The mean MIB-1 index of specimen at the initial surgery (mean \u00b1 a standard deviation: 6.7 \u00b1 4.3%) was significantly (p\u003c0.05) higher in tumors with regrowth than in tumors without regrowth (1.6 \u00b1 0.7%). The mean index of specimens from the intrameatal portion was significantly (p\u003c0.05) lower than in those from the extrameatal portion. In the 66 patients with residual tumors, there was a significant (p\u003c0.05) difference only in MIB-1 index between the patient groups with and without tumor growth. The level of MIB-1 index was significantly and independently associated with the occurrence of tumor growth (multiple linear regression analysis; standard B: 0.714; p\u003c0.001). ln the patients with residual tumors, all of MIB-1 indexes in the tumors with regrowth were more than 3%, while all of those in the tumors without regrowth were less than 3%. The levels of MIB-1 index (log-%) were also significantly (r=-0.785; p\u003c0.001) correlated with the time interval (log-years) between the initial and the second surgery. In 7 of 12 patients with tumor growth, from whom specimen could be obtained at the second surgery, no significant difference was observed in MIB-1 index between specimens at initial and second surgery. These data indicate that the levels of MIB-1 index of acoustic neurinoma at initial surgery seem useful to estimate the proliferative potential of acoustic neurinomas, i.e., the risk of tumor regrowth after initial surgery.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "96354", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Ren, Guang-Xu"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u4efb, \u5149\u65ed"}], "nameIdentifiers": [{"nameIdentifier": "96353", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-07"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "115(4)_148-155.pdf", "filesize": [{"value": "2.1 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2100000.0, "url": {"label": "115(4)_148-155.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/14962/files/115(4)_148-155.pdf"}, "version_id": "cc3a5937-7abd-4965-8229-686691df20e9"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Acoustic neurinoma", "subitem_subject_scheme": "Other"}, {"subitem_subject": "MIB-1", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Proliferative potential", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Regrowth", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u8074\u795e\u7d4c\u9798\u816b", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u5897\u6b96\u80fd", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u518d\u5897\u5927", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "MIB-1 Labeling index\u306b\u3088\u308b\u8074\u795e\u7d4c\u9798\u816b\u306e\u5897\u6b96\u80fd\u306e\u691c\u8a0e", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "MIB-1 Labeling index\u306b\u3088\u308b\u8074\u795e\u7d4c\u9798\u816b\u306e\u5897\u6b96\u80fd\u306e\u691c\u8a0e"}, {"subitem_title": "MIB-1 Labeling index\u306b\u3088\u308b\u8074\u795e\u7d4c\u9798\u816b\u306e\u5897\u6b96\u80fd\u306e\u691c\u8a0e", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/1076"], "permalink_uri": "http://hdl.handle.net/10191/48117", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2017-11-07"}, "publish_date": "2017-11-07", "publish_status": "0", "recid": "14962", "relation": {}, "relation_version_is_last": true, "title": ["MIB-1 Labeling index\u306b\u3088\u308b\u8074\u795e\u7d4c\u9798\u816b\u306e\u5897\u6b96\u80fd\u306e\u691c\u8a0e"], "weko_shared_id": null}