{"created":"2021-03-01T06:19:26.184890+00:00","id":14962,"links":{},"metadata":{"_buckets":{"deposit":"1278cc99-21cf-4de1-b988-54dc49cf51d6"},"_deposit":{"id":"14962","owners":[],"pid":{"revision_id":0,"type":"depid","value":"14962"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00014962","sets":["453:456","471:537:538:1076"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Proliferative Potential of Acoustic Neurinomas Evaluated by MIB-1 Labeling index"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"155","bibliographicPageStart":"148","bibliographicVolumeNumber":"115","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The purpose of this study was to assess the proliferative potential, i.e., tumor regrowth of acoustic neurinomas utilizing the monoclonal antibody MIB-1 labeling index (MIB-1 index). MIB-1 index were examined in 121 consecutive patients with unilateral acoustic neurinoma, 47 males and 74 females, ranging in age from 20 to 76 years. Of the 121 patients, 12 (9.9%) had tumor regrowth after the initial surgery, While none of 55 patients whose tumors were totally removed had no tumor regrowth, 12 (18.2%) of the other 66 patients having residual tumors had regrowth of the tumor. The mean MIB-1 index of specimen at the initial surgery (mean ± a standard deviation: 6.7 ± 4.3%) was significantly (p<0.05) higher in tumors with regrowth than in tumors without regrowth (1.6 ± 0.7%). The mean index of specimens from the intrameatal portion was significantly (p<0.05) lower than in those from the extrameatal portion. In the 66 patients with residual tumors, there was a significant (p<0.05) difference only in MIB-1 index between the patient groups with and without tumor growth. The level of MIB-1 index was significantly and independently associated with the occurrence of tumor growth (multiple linear regression analysis; standard B: 0.714; p<0.001). ln the patients with residual tumors, all of MIB-1 indexes in the tumors with regrowth were more than 3%, while all of those in the tumors without regrowth were less than 3%. The levels of MIB-1 index (log-%) were also significantly (r=-0.785; p<0.001) correlated with the time interval (log-years) between the initial and the second surgery. In 7 of 12 patients with tumor growth, from whom specimen could be obtained at the second surgery, no significant difference was observed in MIB-1 index between specimens at initial and second surgery. These data indicate that the levels of MIB-1 index of acoustic neurinoma at initial surgery seem useful to estimate the proliferative potential of acoustic neurinomas, i.e., the risk of tumor regrowth after initial surgery.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"96354","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Ren, Guang-Xu"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"任, 光旭"}],"nameIdentifiers":[{"nameIdentifier":"96353","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-07"}],"displaytype":"detail","filename":"115(4)_148-155.pdf","filesize":[{"value":"2.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"115(4)_148-155.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/14962/files/115(4)_148-155.pdf"},"version_id":"cc3a5937-7abd-4965-8229-686691df20e9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Acoustic neurinoma","subitem_subject_scheme":"Other"},{"subitem_subject":"MIB-1","subitem_subject_scheme":"Other"},{"subitem_subject":"Proliferative potential","subitem_subject_scheme":"Other"},{"subitem_subject":"Regrowth","subitem_subject_scheme":"Other"},{"subitem_subject":"聴神経鞘腫","subitem_subject_scheme":"Other"},{"subitem_subject":"増殖能","subitem_subject_scheme":"Other"},{"subitem_subject":"再増大","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"MIB-1 Labeling indexによる聴神経鞘腫の増殖能の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"MIB-1 Labeling indexによる聴神経鞘腫の増殖能の検討"},{"subitem_title":"MIB-1 Labeling indexによる聴神経鞘腫の増殖能の検討","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1076"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-11-07"},"publish_date":"2017-11-07","publish_status":"0","recid":"14962","relation_version_is_last":true,"title":["MIB-1 Labeling indexによる聴神経鞘腫の増殖能の検討"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:46:49.345536+00:00"}