@article{oai:niigata-u.repo.nii.ac.jp:00014962,
 author = {任, 光旭},
 issue = {4},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Apr},
 note = {The purpose of this study was to assess the proliferative potential, i.e., tumor regrowth of acoustic neurinomas utilizing the monoclonal antibody MIB-1 labeling index (MIB-1 index). MIB-1 index were examined in 121 consecutive patients with unilateral acoustic neurinoma, 47 males and 74 females, ranging in age from 20 to 76 years. Of the 121 patients, 12 (9.9%) had tumor regrowth after the initial surgery, While none of 55 patients whose tumors were totally removed had no tumor regrowth, 12 (18.2%) of the other 66 patients having residual tumors had regrowth of the tumor. The mean MIB-1 index of specimen at the initial surgery (mean ± a standard deviation: 6.7 ± 4.3%) was significantly (p<0.05) higher in tumors with regrowth than in tumors without regrowth (1.6 ± 0.7%). The mean index of specimens from the intrameatal portion was significantly (p<0.05) lower than in those from the extrameatal portion. In the 66 patients with residual tumors, there was a significant (p<0.05) difference only in MIB-1 index between the patient groups with and without tumor growth. The level of MIB-1 index was significantly and independently associated with the occurrence of tumor growth (multiple linear regression analysis; standard B: 0.714; p<0.001). ln the patients with residual tumors, all of MIB-1 indexes in the tumors with regrowth were more than 3%, while all of those in the tumors without regrowth were less than 3%. The levels of MIB-1 index (log-%) were also significantly (r=-0.785; p<0.001) correlated with the time interval (log-years) between the initial and the second surgery. In 7 of 12 patients with tumor growth, from whom specimen could be obtained at the second surgery, no significant difference was observed in MIB-1 index between specimens at initial and second surgery. These data indicate that the levels of MIB-1 index of acoustic neurinoma at initial surgery seem useful to estimate the proliferative potential of acoustic neurinomas, i.e., the risk of tumor regrowth after initial surgery.},
 pages = {148--155},
 title = {MIB-1 Labeling indexによる聴神経鞘腫の増殖能の検討},
 volume = {115},
 year = {2001}
}