{"_buckets": {"deposit": "9c28a870-cdc5-49ca-ae32-2777fff4a955"}, "_deposit": {"id": "14772", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "14772"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00014772"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "Analysis of Immunoglobulin Gene in the Brain Lymphomas"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2001-08", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "8", "bibliographicPageEnd": "396", "bibliographicPageStart": "385", "bibliographicVolumeNumber": "115", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c"}, {"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "We examined 6 brain lymphomas, pathologically diffuse large B-cell lymphoma, for rearrangements of immunoglobulin heavy chain gene. We amplified the rearranged V_H-D-J_H sequences by RT-PCR, sequenced them, and confirmed their patient-or specimen-specificity by in situ hybridization of individual lymphoma tissues with the use of their own CDR 3 sequences as probes. In subsequent comparative nucleotide analysis and mutation analysis, we found frequent use of V_H 4 gene family (4/6 cases), in particular V 4-34 gene (3/6 cases), and, in all the 6 brain lymphomas, frequent somatic mutations (8.8-27.3%, mean 18.2%) with a significantly low frequency of R (replacement) mutations in the framework regions of V_H gene. These findings suggested that brain lymphomas are related with germinal center lymphocytes, and composed of relatively homogenous tumors in respect of immunological nature.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "95256", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Endo, Sumio"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u9060\u85e4, \u7d14\u7537"}], "nameIdentifiers": [{"nameIdentifier": "95255", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-07"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "115(8)_385-396.pdf", "filesize": [{"value": "2.4 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2400000.0, "url": {"label": "115(8)_385-396.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/14772/files/115(8)_385-396.pdf"}, "version_id": "d74a5344-d858-47f2-89e2-9d3454628d48"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Brain lymphoma", "subitem_subject_scheme": "Other"}, {"subitem_subject": "immunoglobulin gene", "subitem_subject_scheme": "Other"}, {"subitem_subject": "in situ hybridization", "subitem_subject_scheme": "Other"}, {"subitem_subject": "somatic mutation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "on going mutation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "germinal center", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u8133\u539f\u767a\u30ea\u30f3\u30d1\u816b", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u514d\u75ab\u30b0\u30ed\u30d6\u30ea\u30f3\u907a\u4f1d\u5b50", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u4f53\u7d30\u80de\u7a81\u7136\u5909\u7570", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "\u8133\u539f\u767a\u30ea\u30f3\u30d1\u816b\u306b\u304a\u3051\u308b\u514d\u75ab\u30b0\u30ed\u30d6\u30ea\u30f3\u907a\u4f1d\u5b50\u306e\u89e3\u6790", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "\u8133\u539f\u767a\u30ea\u30f3\u30d1\u816b\u306b\u304a\u3051\u308b\u514d\u75ab\u30b0\u30ed\u30d6\u30ea\u30f3\u907a\u4f1d\u5b50\u306e\u89e3\u6790"}, {"subitem_title": "\u8133\u539f\u767a\u30ea\u30f3\u30d1\u816b\u306b\u304a\u3051\u308b\u514d\u75ab\u30b0\u30ed\u30d6\u30ea\u30f3\u907a\u4f1d\u5b50\u306e\u89e3\u6790", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/1072"], "permalink_uri": "http://hdl.handle.net/10191/48348", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2017-11-09"}, "publish_date": "2017-11-09", "publish_status": "0", "recid": "14772", "relation": {}, "relation_version_is_last": true, "title": ["\u8133\u539f\u767a\u30ea\u30f3\u30d1\u816b\u306b\u304a\u3051\u308b\u514d\u75ab\u30b0\u30ed\u30d6\u30ea\u30f3\u907a\u4f1d\u5b50\u306e\u89e3\u6790"], "weko_shared_id": null}