{"created":"2021-03-01T06:19:14.005151+00:00","id":14772,"links":{},"metadata":{"_buckets":{"deposit":"9c28a870-cdc5-49ca-ae32-2777fff4a955"},"_deposit":{"id":"14772","owners":[],"pid":{"revision_id":0,"type":"depid","value":"14772"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00014772","sets":["453:456","471:537:538:1072"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Analysis of Immunoglobulin Gene in the Brain Lymphomas"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"396","bibliographicPageStart":"385","bibliographicVolumeNumber":"115","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We examined 6 brain lymphomas, pathologically diffuse large B-cell lymphoma, for rearrangements of immunoglobulin heavy chain gene. We amplified the rearranged V_H-D-J_H sequences by RT-PCR, sequenced them, and confirmed their patient-or specimen-specificity by in situ hybridization of individual lymphoma tissues with the use of their own CDR 3 sequences as probes. In subsequent comparative nucleotide analysis and mutation analysis, we found frequent use of V_H 4 gene family (4/6 cases), in particular V 4-34 gene (3/6 cases), and, in all the 6 brain lymphomas, frequent somatic mutations (8.8-27.3%, mean 18.2%) with a significantly low frequency of R (replacement) mutations in the framework regions of V_H gene. These findings suggested that brain lymphomas are related with germinal center lymphocytes, and composed of relatively homogenous tumors in respect of immunological nature.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"95256","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Endo, Sumio"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"遠藤, 純男"}],"nameIdentifiers":[{"nameIdentifier":"95255","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-07"}],"displaytype":"detail","filename":"115(8)_385-396.pdf","filesize":[{"value":"2.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"115(8)_385-396.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/14772/files/115(8)_385-396.pdf"},"version_id":"d74a5344-d858-47f2-89e2-9d3454628d48"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Brain lymphoma","subitem_subject_scheme":"Other"},{"subitem_subject":"immunoglobulin gene","subitem_subject_scheme":"Other"},{"subitem_subject":"in situ hybridization","subitem_subject_scheme":"Other"},{"subitem_subject":"somatic mutation","subitem_subject_scheme":"Other"},{"subitem_subject":"on going mutation","subitem_subject_scheme":"Other"},{"subitem_subject":"germinal center","subitem_subject_scheme":"Other"},{"subitem_subject":"脳原発リンパ腫","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫グロブリン遺伝子","subitem_subject_scheme":"Other"},{"subitem_subject":"体細胞突然変異","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"脳原発リンパ腫における免疫グロブリン遺伝子の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"脳原発リンパ腫における免疫グロブリン遺伝子の解析"},{"subitem_title":"脳原発リンパ腫における免疫グロブリン遺伝子の解析","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1072"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-11-09"},"publish_date":"2017-11-09","publish_status":"0","recid":"14772","relation_version_is_last":true,"title":["脳原発リンパ腫における免疫グロブリン遺伝子の解析"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:46:42.525002+00:00"}