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心疾患モデル動物を用いた不全心筋治療へのアプローチ

http://hdl.handle.net/10191/2587

	名前 / ファイル	ライセンス	アクション
	KJ00004300196.pdf (1.2 MB)

Item type

紀要論文 / Departmental Bulletin Paper(1)

公開日

2007-05-10

タイトル

心疾患モデル動物を用いた不全心筋治療へのアプローチ

タイトル

言語

タイトル

心疾患モデル動物を用いた不全心筋治療へのアプローチ

言語

jpn

キーワード

主題Scheme

Other

主題

レニン・アンジオテンシン・アルデステロン

キーワード

主題Scheme

Other

主題

インターロイキン-10

キーワード

主題Scheme

Other

主題

14-3-3蛋白

キーワード

主題Scheme

Other

主題

MAPK

キーワード

主題Scheme

Other

主題

アポトーシス

資源タイプ

資源

http://purl.org/coar/resource_type/c_6501

タイプ

departmental bulletin paper

その他のタイトル

Researches of Heart Failure Using Animal Models

著者

渡辺, 賢一

馬, 梅蕾
平林, 賢一

曽我, 真也子

文, 娟
Wahed, Mir
G, Narasimman

P, Suresh
Prakash, Paras

抄録

内容記述タイプ

Abstract

内容記述

(1)心不全においては過度の交感神経緊張が悪循環を形成し,それを断ち切るためにβ-遮断薬が使用される.更に,レニン・アンジオテンシン・アルデステロン系(RAA)の係わりが最近注目されている.心不全モデルラットに,β-遮断薬・RAA阻害薬等を投与し心機能の改善が見られた.更に,β-遮断薬は心筋交感神経機能を改善し,RAA阻害薬は線維化と関連するTGF-β1とコラーゲンIIIのmRNA発現を抑制した.(2)サイトカインのインターロイキン(IL)-10は,炎症性サイトカインの産生を抑制する.心筋炎モデルラットにIL-10を投与すると,心臓のマスト細胞やヒスタミンが減少した.更に,心機能の改善も見られた.(3)アポトーシスは不全心筋とも密接に関係する.特に糖尿病を合併する心筋ではアポトーシスがおきやすい.14-3-3蛋白はシグナルトランスダクションを調節し,心筋アポトーシスに関係する. Dominant Negative14-3-3(TG)マウスを用い,糖尿病と心筋アポトーシスを検討した.TGマウスではMAPKのD38MAPKやJNKの活性化とアポトーシスが見られた.

書誌情報

新潟医学会雑誌
en : 新潟医学会雑誌

巻 119, 号 5, p. 277-283, 発行日 2005-05

出版者

新潟医学会

ISSN

収録物識別子タイプ

ISSN

収録物識別子

00290440

書誌レコードID

収録物識別子タイプ

NCID

収録物識別子

AN00182415

著者版フラグ

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心疾患モデル動物を用いた不全心筋治療へのアプローチ

× 渡辺, 賢一

× 馬, 梅蕾

× 平林, 賢一

× 曽我, 真也子

× 文, 娟

× Wahed, Mir

× G, Narasimman

× P, Suresh

× Prakash, Paras

× K, Fadia Ali

× 水戸, 沙耶佳

× 白井, 健

× 長井, 悠輔

× 太刀川, 仁

× 小玉, 誠

× 相澤, 義房

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