{"_buckets": {"deposit": "36882b99-47dd-4c32-bbd0-2a04da3be872"}, "_deposit": {"id": "12554", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "12554"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00012554", "sets": ["456", "1027"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Researches of Heart Failure Using Animal Models"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2005-05", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "5", "bibliographicPageEnd": "283", "bibliographicPageStart": "277", "bibliographicVolumeNumber": "119", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "(1)心不全においては過度の交感神経緊張が悪循環を形成し,それを断ち切るためにβ-遮断薬が使用される.更に,レニン・アンジオテンシン・アルデステロン系(RAA)の係わりが最近注目されている.心不全モデルラットに,β-遮断薬・RAA阻害薬等を投与し心機能の改善が見られた.更に,β-遮断薬は心筋交感神経機能を改善し,RAA阻害薬は線維化と関連するTGF-β1とコラーゲンIIIのmRNA発現を抑制した.(2)サイトカインのインターロイキン(IL)-10は,炎症性サイトカインの産生を抑制する.心筋炎モデルラットにIL-10を投与すると,心臓のマスト細胞やヒスタミンが減少した.更に,心機能の改善も見られた.(3)アポトーシスは不全心筋とも密接に関係する.特に糖尿病を合併する心筋ではアポトーシスがおきやすい.14-3-3蛋白はシグナルトランスダクションを調節し,心筋アポトーシスに関係する. Dominant Negative14-3-3(TG)マウスを用い,糖尿病と心筋アポトーシスを検討した.TGマウスではMAPKのD38MAPKやJNKの活性化とアポトーシスが見られた.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "渡辺, 賢一"}], "nameIdentifiers": [{"nameIdentifier": "83684", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "馬, 梅蕾"}], "nameIdentifiers": [{"nameIdentifier": "83685", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "平林, 賢一"}], "nameIdentifiers": [{"nameIdentifier": "83686", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "曽我, 真也子"}], "nameIdentifiers": [{"nameIdentifier": "83687", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "文, 娟"}], "nameIdentifiers": [{"nameIdentifier": "83688", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Wahed, Mir"}], "nameIdentifiers": [{"nameIdentifier": "83689", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "G, Narasimman"}], "nameIdentifiers": [{"nameIdentifier": "83690", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "P, Suresh"}], "nameIdentifiers": [{"nameIdentifier": "83691", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Prakash, Paras"}], "nameIdentifiers": [{"nameIdentifier": "83692", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "K, Fadia Ali"}], "nameIdentifiers": [{"nameIdentifier": "83693", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "水戸, 沙耶佳"}], "nameIdentifiers": [{"nameIdentifier": "83694", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "白井, 健"}], "nameIdentifiers": [{"nameIdentifier": "83695", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "長井, 悠輔"}], "nameIdentifiers": [{"nameIdentifier": "83696", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "太刀川, 仁"}], "nameIdentifiers": [{"nameIdentifier": "83697", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "小玉, 誠"}], "nameIdentifiers": [{"nameIdentifier": "83698", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "相澤, 義房"}], "nameIdentifiers": [{"nameIdentifier": "83699", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-07"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00004300196.pdf", "filesize": [{"value": "1.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1200000.0, "url": {"label": "KJ00004300196.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/12554/files/KJ00004300196.pdf"}, "version_id": "4236cdf4-53f2-46fd-9c99-3d7ef6b2b1fe"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "レニン・アンジオテンシン・アルデステロン", "subitem_subject_scheme": "Other"}, {"subitem_subject": "インターロイキン-10", "subitem_subject_scheme": "Other"}, {"subitem_subject": "14-3-3蛋白", "subitem_subject_scheme": "Other"}, {"subitem_subject": "MAPK", "subitem_subject_scheme": "Other"}, {"subitem_subject": "アポトーシス", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "心疾患モデル動物を用いた不全心筋治療へのアプローチ", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "心疾患モデル動物を用いた不全心筋治療へのアプローチ"}, {"subitem_title": "心疾患モデル動物を用いた不全心筋治療へのアプローチ", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1027"], "permalink_uri": "http://hdl.handle.net/10191/2587", "pubdate": {"attribute_name": "公開日", "attribute_value": "2007-05-10"}, "publish_date": "2007-05-10", "publish_status": "0", "recid": "12554", "relation": {}, "relation_version_is_last": true, "title": ["心疾患モデル動物を用いた不全心筋治療へのアプローチ"], "weko_shared_id": null}