{"created":"2021-03-01T06:16:50.230228+00:00","id":12554,"links":{},"metadata":{"_buckets":{"deposit":"36882b99-47dd-4c32-bbd0-2a04da3be872"},"_deposit":{"id":"12554","owners":[],"pid":{"revision_id":0,"type":"depid","value":"12554"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00012554","sets":["453:456","471:537:538:1027"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Researches of Heart Failure Using Animal Models"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"283","bibliographicPageStart":"277","bibliographicVolumeNumber":"119","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"(1)心不全においては過度の交感神経緊張が悪循環を形成し,それを断ち切るためにβ-遮断薬が使用される.更に,レニン・アンジオテンシン・アルデステロン系(RAA)の係わりが最近注目されている.心不全モデルラットに,β-遮断薬・RAA阻害薬等を投与し心機能の改善が見られた.更に,β-遮断薬は心筋交感神経機能を改善し,RAA阻害薬は線維化と関連するTGF-β1とコラーゲンIIIのmRNA発現を抑制した.(2)サイトカインのインターロイキン(IL)-10は,炎症性サイトカインの産生を抑制する.心筋炎モデルラットにIL-10を投与すると,心臓のマスト細胞やヒスタミンが減少した.更に,心機能の改善も見られた.(3)アポトーシスは不全心筋とも密接に関係する.特に糖尿病を合併する心筋ではアポトーシスがおきやすい.14-3-3蛋白はシグナルトランスダクションを調節し,心筋アポトーシスに関係する. Dominant Negative14-3-3(TG)マウスを用い,糖尿病と心筋アポトーシスを検討した.TGマウスではMAPKのD38MAPKやJNKの活性化とアポトーシスが見られた.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"渡辺, 賢一"}],"nameIdentifiers":[{"nameIdentifier":"83684","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"馬, 梅蕾"}],"nameIdentifiers":[{"nameIdentifier":"83685","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平林, 賢一"}],"nameIdentifiers":[{"nameIdentifier":"83686","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"曽我, 真也子"}],"nameIdentifiers":[{"nameIdentifier":"83687","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"文, 娟"}],"nameIdentifiers":[{"nameIdentifier":"83688","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wahed, Mir"}],"nameIdentifiers":[{"nameIdentifier":"83689","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"G, Narasimman"}],"nameIdentifiers":[{"nameIdentifier":"83690","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"P, Suresh"}],"nameIdentifiers":[{"nameIdentifier":"83691","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Prakash, Paras"}],"nameIdentifiers":[{"nameIdentifier":"83692","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"K, Fadia Ali"}],"nameIdentifiers":[{"nameIdentifier":"83693","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"水戸, 沙耶佳"}],"nameIdentifiers":[{"nameIdentifier":"83694","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"白井, 健"}],"nameIdentifiers":[{"nameIdentifier":"83695","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"長井, 悠輔"}],"nameIdentifiers":[{"nameIdentifier":"83696","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"太刀川, 仁"}],"nameIdentifiers":[{"nameIdentifier":"83697","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小玉, 誠"}],"nameIdentifiers":[{"nameIdentifier":"83698","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"相澤, 義房"}],"nameIdentifiers":[{"nameIdentifier":"83699","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-07"}],"displaytype":"detail","filename":"KJ00004300196.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00004300196.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/12554/files/KJ00004300196.pdf"},"version_id":"4236cdf4-53f2-46fd-9c99-3d7ef6b2b1fe"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"レニン・アンジオテンシン・アルデステロン","subitem_subject_scheme":"Other"},{"subitem_subject":"インターロイキン-10","subitem_subject_scheme":"Other"},{"subitem_subject":"14-3-3蛋白","subitem_subject_scheme":"Other"},{"subitem_subject":"MAPK","subitem_subject_scheme":"Other"},{"subitem_subject":"アポトーシス","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"心疾患モデル動物を用いた不全心筋治療へのアプローチ","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"心疾患モデル動物を用いた不全心筋治療へのアプローチ"},{"subitem_title":"心疾患モデル動物を用いた不全心筋治療へのアプローチ","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1027"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-05-10"},"publish_date":"2007-05-10","publish_status":"0","recid":"12554","relation_version_is_last":true,"title":["心疾患モデル動物を用いた不全心筋治療へのアプローチ"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:45:21.558679+00:00"}