WEKO3
AND
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There were eight subjects with normal blood pressure (Group-N) and ten with mild elevated blood pressure or mild hypertension (Group-H)(male/female=13/5, 46\u00b13 years old, systolic blood pressure=118\u00b13mmHg in Group-N and 136\u00b12mmHg in Group-H). All subjects took 90ml of drinking water, the concentration of GABA was 70mg/90ml/one piece, for 12 weeks. Blood pressure did not change during the intake in Group-N. Systolic blood pressure decreased from 6 weeks, and significantly decreased at 10 and 12 weeks during the intake in Group-H (129\u00b13mmHg and 128\u00b14mmHg respectively, p\u003c0.05). Interestingly, systolic blood pressure further decreased at 2 weeks after stopping the intake (126\u00b13mmHg, p\u003c0.05), and blood pressure recovered at 4 weeks after stopping the intake (130\u00b14mmHg). Although there were no abnormal changes in blood and urinalysis tests, fasting blood glucose (from 91\u00b12mg/dl to 88\u00b12mg/dl, p\u003c0.05), GOT (from 23\u00b11mg/dl to 21\u00b11mg/dl, p\u003c0.05), \u03b3-GTP (from 37\u00b17mg/dl to 28\u00b15mg/dl, p\u003c0.05), LDH (from 187\u00b15mg/dl to 176\u00b15mg/dl, p\u003c0.05) and total cholesterol (from 192\u00b17mg/dl to 183\u00b16mg/dl, NS) decreased after the intake. No adverse reaction was observed in a medical examination and subjective symptoms. 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正常血圧者及び正常高値血圧者・軽症高血圧患者におけるGABAおよびリンゴ酢含有飲料水(顆糖熟®)長期摂取時の有効性と安全性
http://hdl.handle.net/10191/5276
17f717e0-a2ec-4f35-99f8-4698e6605379
| 名前 / ファイル | ライセンス | アクション | |
|---|---|---|---|
21_0005.pdf (877.4 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-04-08 | |||||
| タイトル | ||||||
| タイトル | 正常血圧者及び正常高値血圧者・軽症高血圧患者におけるGABAおよびリンゴ酢含有飲料水(顆糖熟®)長期摂取時の有効性と安全性 | |||||
| タイトル | ||||||
| 言語 | en | |||||
| タイトル | 正常血圧者及び正常高値血圧者・軽症高血圧患者におけるGABAおよびリンゴ酢含有飲料水(顆糖熟®)長期摂取時の有効性と安全性 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | GABA | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | リンゴ酢 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 軽症高血圧 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 健康・栄養食品 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 顆糖熟® | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | コレステロール | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 血糖 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | GABA | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | vinegar | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | mild hypertension | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | nutritional food | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | katonal® | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cholesterol | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | blood glucose | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| その他のタイトル | ||||||
| その他のタイトル | Effects of γ-aminobutyric Acid (GABA) and Vinegar, Katonal, in Subjects with Mild Elevated Blood Pressure | |||||
| 著者 |
渡辺, 賢一
× 渡辺, 賢一× 井上, 幹雄× 中野, るりこ× 文, 娟× 国崎, 恵× 水戸, 沙耶佳× 馬, 梅蕾× プニヤコッテイ, Tv× ナラシマン, G× スレシュ, Ps× パラス, P× ワヘッド, M× ファデア, Ka× リヤド, Ae× ベナム, H× 平山, 匡男× 小林, 隆司× 小山, 博史× 神田, 光雄 |
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| 著者別名 | ||||||
| 識別子 | ||||||
| 識別子 | 81795 | |||||
| 識別子Scheme | WEKO | |||||
| 姓名 | ||||||
| 姓名 | Watanabe, Kenichi | |||||
| 著者別名 | ||||||
| 識別子 | ||||||
| 識別子 | 81796 | |||||
| 識別子Scheme | WEKO | |||||
| 姓名 | ||||||
| 姓名 | Inoue, Mikio | |||||
| 著者別名 | ||||||
| 識別子 | ||||||
| 識別子 | 81797 | |||||
| 識別子Scheme | WEKO | |||||
| 姓名 | ||||||
| 姓名 | Nakano, Ruriko | |||||
| 著者別名 | ||||||
| 識別子 | ||||||
| 識別子 | 81798 | |||||
| 識別子Scheme | WEKO | |||||
| 姓名 | ||||||
| 姓名 | Wen, Juan | |||||
| 著者別名 | ||||||
| 識別子 | ||||||
| 識別子 | 81799 | |||||
| 識別子Scheme | WEKO | |||||
| 姓名 | ||||||
| 姓名 | Kunizaki, Megumi | |||||
| 著者別名 | ||||||
| 識別子 | ||||||
| 識別子 | 81800 | |||||
| 識別子Scheme | WEKO | |||||
| 姓名 | ||||||
| 姓名 | Mito, Sayaka | |||||
| 著者別名 | ||||||
| 識別子 | ||||||
| 識別子 | 81801 | |||||
| 識別子Scheme | WEKO | |||||
| 姓名 | ||||||
| 姓名 | Meilei, Ma | |||||
| 著者別名 | ||||||
| 識別子 | ||||||
| 識別子 | 81802 | |||||
| 識別子Scheme | WEKO | |||||
| 姓名 | ||||||
| 姓名 | Punniyakoti, T Veeraveedu | |||||
| 著者別名 | ||||||
| 識別子 | ||||||
| 識別子 | 81803 | |||||
| 識別子Scheme | WEKO | |||||
| 姓名 | ||||||
| 姓名 | Narasimman, Gurusamy | |||||
| 著者別名 | ||||||
| 識別子 | ||||||
| 識別子 | 81804 | |||||
| 識別子Scheme | WEKO | |||||
| 姓名 | ||||||
| 姓名 | Suresh, P. Selvaraj | |||||
| 著者別名 | ||||||
| 識別子 | ||||||
| 識別子 | 81805 | |||||
| 識別子Scheme | WEKO | |||||
| 姓名 | ||||||
| 姓名 | Paras, Prakash | |||||
| 著者別名 | ||||||
| 識別子 | ||||||
| 識別子 | 81806 | |||||
| 識別子Scheme | WEKO | |||||
| 姓名 | ||||||
| 姓名 | Wahed, Mir | |||||
| 著者別名 | ||||||
| 識別子 | ||||||
| 識別子 | 81807 | |||||
| 識別子Scheme | WEKO | |||||
| 姓名 | ||||||
| 姓名 | Fadia, K. Ali | |||||
| 著者別名 | ||||||
| 識別子 | ||||||
| 識別子 | 81808 | |||||
| 識別子Scheme | WEKO | |||||
| 姓名 | ||||||
| 姓名 | Reyad, A. Elbarbary | |||||
| 著者別名 | ||||||
| 識別子 | ||||||
| 識別子 | 81809 | |||||
| 識別子Scheme | WEKO | |||||
| 姓名 | ||||||
| 姓名 | Behnam, Heshmatian | |||||
| 著者別名 | ||||||
| 識別子 | ||||||
| 識別子 | 81810 | |||||
| 識別子Scheme | WEKO | |||||
| 姓名 | ||||||
| 姓名 | Hirayama, Masao | |||||
| 著者別名 | ||||||
| 識別子 | ||||||
| 識別子 | 81811 | |||||
| 識別子Scheme | WEKO | |||||
| 姓名 | ||||||
| 姓名 | Kobayashi, Takashi | |||||
| 著者別名 | ||||||
| 識別子 | ||||||
| 識別子 | 81812 | |||||
| 識別子Scheme | WEKO | |||||
| 姓名 | ||||||
| 姓名 | Oyama, Hiroshi | |||||
| 著者別名 | ||||||
| 識別子 | ||||||
| 識別子 | 81813 | |||||
| 識別子Scheme | WEKO | |||||
| 姓名 | ||||||
| 姓名 | Kanda, Mitsuo | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | 【目的】γ-aminobutyric acid (GABA)・リンゴ酢含有飲料水「顆糖熟(かとなーる)®」の血圧に及ぼす作用と安全性を検討した.【方法】対象は,正常血圧者(収縮期血圧130mmHg未満かつ拡張期血圧85mmHg未満.N群.8名)と未治療正常高値血圧者(収縮期血圧130-139mmHgまたは拡張期血圧85-89mmHg)・軽症高血圧患者(収縮期血圧140-159mmHgまたは拡張期血圧90-99mmHg)のH群(10名)のボランテア計18名(男/女=13/5.平均46±3歳.)である.1本90mlにGABA70mg含有する飲料水「顆糖熟®」を1日1本12週間摂取し,2週間毎に血圧・血液生化学・尿を検査した.【結果】診察所見・自覚所見で有害事象は見られなかった.N群では摂取による血圧の有意な変化は見られなかった(収縮期血圧118±3mmHgから113±4mmHg).H群では,摂取6週目から血圧低下が見られ,開始日(収縮期血圧136±2mmHg)と比較して10・12週目に有意な低下が見られた(収縮期血圧129±3・128±4mmHg,両p<0.05).興味深いことに,摂取中止2週後は更に血圧が低下し(126±3mmHg,p<0.05),中止4過後に血圧が上昇してきて摂取前と差が見られなくなった(130±4mmHg).摂取による血液生化学・尿検査の異常変化は見られなかったが,血糖値・GOT・γ-GTP・LDHの有意な低下と総コレステロール値の低下傾向が見られた.【総括】GABA含有飲料水「顆糖熟®」は正常高値血圧者・軽症高血圧患者で緩やかに血圧を降下させ,安全性が高いことが示唆された.We investigated the effects of drinking water containing γ-aminobutyric acid (GABA) and vinegar, Katonal®, on blood pressure and safety in volunteers. There were eight subjects with normal blood pressure (Group-N) and ten with mild elevated blood pressure or mild hypertension (Group-H)(male/female=13/5, 46±3 years old, systolic blood pressure=118±3mmHg in Group-N and 136±2mmHg in Group-H). All subjects took 90ml of drinking water, the concentration of GABA was 70mg/90ml/one piece, for 12 weeks. Blood pressure did not change during the intake in Group-N. Systolic blood pressure decreased from 6 weeks, and significantly decreased at 10 and 12 weeks during the intake in Group-H (129±3mmHg and 128±4mmHg respectively, p<0.05). Interestingly, systolic blood pressure further decreased at 2 weeks after stopping the intake (126±3mmHg, p<0.05), and blood pressure recovered at 4 weeks after stopping the intake (130±4mmHg). Although there were no abnormal changes in blood and urinalysis tests, fasting blood glucose (from 91±2mg/dl to 88±2mg/dl, p<0.05), GOT (from 23±1mg/dl to 21±1mg/dl, p<0.05), γ-GTP (from 37±7mg/dl to 28±5mg/dl, p<0.05), LDH (from 187±5mg/dl to 176±5mg/dl, p<0.05) and total cholesterol (from 192±7mg/dl to 183±6mg/dl, NS) decreased after the intake. No adverse reaction was observed in a medical examination and subjective symptoms. These results demonstrate that this drinking water exhibits mild hypotensive effect in subjects with mild hypertension, and its long-term intake does not cause any adverse reaction. | |||||
| 書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 120, 号 5, p. 279-289, 発行日 2006-05 |
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| 出版者 | ||||||
| 出版者 | 新潟医学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00290440 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00182415 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
