{"_buckets": {"deposit": "8813169e-6e23-478d-a6c9-5e6d3cf04ec2"}, "_deposit": {"id": "12173", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "12173"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00012173", "sets": ["456", "1015"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Effects of γ-aminobutyric Acid (GABA) and Vinegar, Katonal, in Subjects with Mild Elevated Blood Pressure"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2006-05", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "5", "bibliographicPageEnd": "289", "bibliographicPageStart": "279", "bibliographicVolumeNumber": "120", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "【目的】γ-aminobutyric acid (GABA)・リンゴ酢含有飲料水「顆糖熟(かとなーる)®」の血圧に及ぼす作用と安全性を検討した.【方法】対象は,正常血圧者(収縮期血圧130mmHg未満かつ拡張期血圧85mmHg未満.N群.8名)と未治療正常高値血圧者(収縮期血圧130-139mmHgまたは拡張期血圧85-89mmHg)・軽症高血圧患者(収縮期血圧140-159mmHgまたは拡張期血圧90-99mmHg)のH群(10名)のボランテア計18名(男/女=13/5.平均46±3歳.)である.1本90mlにGABA70mg含有する飲料水「顆糖熟®」を1日1本12週間摂取し,2週間毎に血圧・血液生化学・尿を検査した.【結果】診察所見・自覚所見で有害事象は見られなかった.N群では摂取による血圧の有意な変化は見られなかった(収縮期血圧118±3mmHgから113±4mmHg).H群では,摂取6週目から血圧低下が見られ,開始日(収縮期血圧136±2mmHg)と比較して10・12週目に有意な低下が見られた(収縮期血圧129±3・128±4mmHg,両p\u003c0.05).興味深いことに,摂取中止2週後は更に血圧が低下し(126±3mmHg,p\u003c0.05),中止4過後に血圧が上昇してきて摂取前と差が見られなくなった(130±4mmHg).摂取による血液生化学・尿検査の異常変化は見られなかったが,血糖値・GOT・γ-GTP・LDHの有意な低下と総コレステロール値の低下傾向が見られた.【総括】GABA含有飲料水「顆糖熟®」は正常高値血圧者・軽症高血圧患者で緩やかに血圧を降下させ,安全性が高いことが示唆された.We investigated the effects of drinking water containing γ-aminobutyric acid (GABA) and vinegar, Katonal®, on blood pressure and safety in volunteers. There were eight subjects with normal blood pressure (Group-N) and ten with mild elevated blood pressure or mild hypertension (Group-H)(male/female=13/5, 46±3 years old, systolic blood pressure=118±3mmHg in Group-N and 136±2mmHg in Group-H). All subjects took 90ml of drinking water, the concentration of GABA was 70mg/90ml/one piece, for 12 weeks. Blood pressure did not change during the intake in Group-N. Systolic blood pressure decreased from 6 weeks, and significantly decreased at 10 and 12 weeks during the intake in Group-H (129±3mmHg and 128±4mmHg respectively, p\u003c0.05). Interestingly, systolic blood pressure further decreased at 2 weeks after stopping the intake (126±3mmHg, p\u003c0.05), and blood pressure recovered at 4 weeks after stopping the intake (130±4mmHg). Although there were no abnormal changes in blood and urinalysis tests, fasting blood glucose (from 91±2mg/dl to 88±2mg/dl, p\u003c0.05), GOT (from 23±1mg/dl to 21±1mg/dl, p\u003c0.05), γ-GTP (from 37±7mg/dl to 28±5mg/dl, p\u003c0.05), LDH (from 187±5mg/dl to 176±5mg/dl, p\u003c0.05) and total cholesterol (from 192±7mg/dl to 183±6mg/dl, NS) decreased after the intake. No adverse reaction was observed in a medical examination and subjective symptoms. These results demonstrate that this drinking water exhibits mild hypotensive effect in subjects with mild hypertension, and its long-term intake does not cause any adverse reaction.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "81795", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Watanabe, Kenichi"}]}, {"nameIdentifiers": [{"nameIdentifier": "81796", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Inoue, Mikio"}]}, {"nameIdentifiers": [{"nameIdentifier": "81797", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Nakano, Ruriko"}]}, {"nameIdentifiers": [{"nameIdentifier": "81798", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Wen, Juan"}]}, {"nameIdentifiers": [{"nameIdentifier": "81799", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Kunizaki, Megumi"}]}, {"nameIdentifiers": [{"nameIdentifier": "81800", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Mito, Sayaka"}]}, {"nameIdentifiers": [{"nameIdentifier": "81801", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Meilei, Ma"}]}, {"nameIdentifiers": [{"nameIdentifier": "81802", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Punniyakoti, T Veeraveedu"}]}, {"nameIdentifiers": [{"nameIdentifier": "81803", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Narasimman, Gurusamy"}]}, {"nameIdentifiers": [{"nameIdentifier": "81804", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Suresh, P. Selvaraj"}]}, {"nameIdentifiers": [{"nameIdentifier": "81805", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Paras, Prakash"}]}, {"nameIdentifiers": [{"nameIdentifier": "81806", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Wahed, Mir"}]}, {"nameIdentifiers": [{"nameIdentifier": "81807", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Fadia, K. Ali"}]}, {"nameIdentifiers": [{"nameIdentifier": "81808", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Reyad, A. Elbarbary"}]}, {"nameIdentifiers": [{"nameIdentifier": "81809", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Behnam, Heshmatian"}]}, {"nameIdentifiers": [{"nameIdentifier": "81810", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Hirayama, Masao"}]}, {"nameIdentifiers": [{"nameIdentifier": "81811", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Kobayashi, Takashi"}]}, {"nameIdentifiers": [{"nameIdentifier": "81812", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Oyama, Hiroshi"}]}, {"nameIdentifiers": [{"nameIdentifier": "81813", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Kanda, Mitsuo"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "渡辺, 賢一"}], "nameIdentifiers": [{"nameIdentifier": "81776", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "井上, 幹雄"}], "nameIdentifiers": [{"nameIdentifier": "81777", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "中野, るりこ"}], "nameIdentifiers": [{"nameIdentifier": "81778", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "文, 娟"}], "nameIdentifiers": [{"nameIdentifier": "81779", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "国崎, 恵"}], "nameIdentifiers": [{"nameIdentifier": "81780", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "水戸, 沙耶佳"}], "nameIdentifiers": [{"nameIdentifier": "81781", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "馬, 梅蕾"}], "nameIdentifiers": [{"nameIdentifier": "81782", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "プニヤコッテイ, Tv"}], "nameIdentifiers": [{"nameIdentifier": "81783", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "ナラシマン, G"}], "nameIdentifiers": [{"nameIdentifier": "81784", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "スレシュ, Ps"}], "nameIdentifiers": [{"nameIdentifier": "81785", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "パラス, P"}], "nameIdentifiers": [{"nameIdentifier": "81786", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "ワヘッド, M"}], "nameIdentifiers": [{"nameIdentifier": "81787", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "ファデア, Ka"}], "nameIdentifiers": [{"nameIdentifier": "81788", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "リヤド, Ae"}], "nameIdentifiers": [{"nameIdentifier": "81789", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "ベナム, H"}], "nameIdentifiers": [{"nameIdentifier": "81790", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "平山, 匡男"}], "nameIdentifiers": [{"nameIdentifier": "81791", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "小林, 隆司"}], "nameIdentifiers": [{"nameIdentifier": "81792", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "小山, 博史"}], "nameIdentifiers": [{"nameIdentifier": "81793", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "神田, 光雄"}], "nameIdentifiers": [{"nameIdentifier": "81794", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-07"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "21_0005.pdf", "filesize": [{"value": "877.4 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 877400.0, "url": {"label": "21_0005.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/12173/files/21_0005.pdf"}, "version_id": "3afa443b-7d4c-4e67-982e-2bd69d76cfe7"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "GABA", "subitem_subject_scheme": "Other"}, {"subitem_subject": "リンゴ酢", "subitem_subject_scheme": "Other"}, {"subitem_subject": "軽症高血圧", "subitem_subject_scheme": "Other"}, {"subitem_subject": "健康・栄養食品", "subitem_subject_scheme": "Other"}, {"subitem_subject": "顆糖熟®", "subitem_subject_scheme": "Other"}, {"subitem_subject": "コレステロール", "subitem_subject_scheme": "Other"}, {"subitem_subject": "血糖", "subitem_subject_scheme": "Other"}, {"subitem_subject": "GABA", "subitem_subject_scheme": "Other"}, {"subitem_subject": "vinegar", "subitem_subject_scheme": "Other"}, {"subitem_subject": "mild hypertension", "subitem_subject_scheme": "Other"}, {"subitem_subject": "nutritional food", "subitem_subject_scheme": "Other"}, {"subitem_subject": "katonal®", "subitem_subject_scheme": "Other"}, {"subitem_subject": "cholesterol", "subitem_subject_scheme": "Other"}, {"subitem_subject": "blood glucose", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "正常血圧者及び正常高値血圧者・軽症高血圧患者におけるGABAおよびリンゴ酢含有飲料水(顆糖熟®)長期摂取時の有効性と安全性", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "正常血圧者及び正常高値血圧者・軽症高血圧患者におけるGABAおよびリンゴ酢含有飲料水(顆糖熟®)長期摂取時の有効性と安全性"}, {"subitem_title": "正常血圧者及び正常高値血圧者・軽症高血圧患者におけるGABAおよびリンゴ酢含有飲料水(顆糖熟®)長期摂取時の有効性と安全性", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1015"], "permalink_uri": "http://hdl.handle.net/10191/5276", "pubdate": {"attribute_name": "公開日", "attribute_value": "2008-04-08"}, "publish_date": "2008-04-08", "publish_status": "0", "recid": "12173", "relation": {}, "relation_version_is_last": true, "title": ["正常血圧者及び正常高値血圧者・軽症高血圧患者におけるGABAおよびリンゴ酢含有飲料水(顆糖熟®)長期摂取時の有効性と安全性"], "weko_shared_id": null}