{"created":"2021-03-01T06:16:25.798804+00:00","id":12173,"links":{},"metadata":{"_buckets":{"deposit":"8813169e-6e23-478d-a6c9-5e6d3cf04ec2"},"_deposit":{"id":"12173","owners":[],"pid":{"revision_id":0,"type":"depid","value":"12173"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00012173","sets":["453:456","471:537:538:1015"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Effects of γ-aminobutyric Acid (GABA) and Vinegar, Katonal, in Subjects with Mild Elevated Blood Pressure"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"289","bibliographicPageStart":"279","bibliographicVolumeNumber":"120","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】γ-aminobutyric acid (GABA)・リンゴ酢含有飲料水「顆糖熟(かとなーる)®」の血圧に及ぼす作用と安全性を検討した.【方法】対象は,正常血圧者(収縮期血圧130mmHg未満かつ拡張期血圧85mmHg未満.N群.8名)と未治療正常高値血圧者(収縮期血圧130-139mmHgまたは拡張期血圧85-89mmHg)・軽症高血圧患者(収縮期血圧140-159mmHgまたは拡張期血圧90-99mmHg)のH群(10名)のボランテア計18名(男/女=13/5.平均46±3歳.)である.1本90mlにGABA70mg含有する飲料水「顆糖熟®」を1日1本12週間摂取し,2週間毎に血圧・血液生化学・尿を検査した.【結果】診察所見・自覚所見で有害事象は見られなかった.N群では摂取による血圧の有意な変化は見られなかった(収縮期血圧118±3mmHgから113±4mmHg).H群では,摂取6週目から血圧低下が見られ,開始日(収縮期血圧136±2mmHg)と比較して10・12週目に有意な低下が見られた(収縮期血圧129±3・128±4mmHg,両p<0.05).興味深いことに,摂取中止2週後は更に血圧が低下し(126±3mmHg,p<0.05),中止4過後に血圧が上昇してきて摂取前と差が見られなくなった(130±4mmHg).摂取による血液生化学・尿検査の異常変化は見られなかったが,血糖値・GOT・γ-GTP・LDHの有意な低下と総コレステロール値の低下傾向が見られた.【総括】GABA含有飲料水「顆糖熟®」は正常高値血圧者・軽症高血圧患者で緩やかに血圧を降下させ,安全性が高いことが示唆された.We investigated the effects of drinking water containing γ-aminobutyric acid (GABA) and vinegar, Katonal®, on blood pressure and safety in volunteers. There were eight subjects with normal blood pressure (Group-N) and ten with mild elevated blood pressure or mild hypertension (Group-H)(male/female=13/5, 46±3 years old, systolic blood pressure=118±3mmHg in Group-N and 136±2mmHg in Group-H). All subjects took 90ml of drinking water, the concentration of GABA was 70mg/90ml/one piece, for 12 weeks. Blood pressure did not change during the intake in Group-N. Systolic blood pressure decreased from 6 weeks, and significantly decreased at 10 and 12 weeks during the intake in Group-H (129±3mmHg and 128±4mmHg respectively, p<0.05). Interestingly, systolic blood pressure further decreased at 2 weeks after stopping the intake (126±3mmHg, p<0.05), and blood pressure recovered at 4 weeks after stopping the intake (130±4mmHg). Although there were no abnormal changes in blood and urinalysis tests, fasting blood glucose (from 91±2mg/dl to 88±2mg/dl, p<0.05), GOT (from 23±1mg/dl to 21±1mg/dl, p<0.05), γ-GTP (from 37±7mg/dl to 28±5mg/dl, p<0.05), LDH (from 187±5mg/dl to 176±5mg/dl, p<0.05) and total cholesterol (from 192±7mg/dl to 183±6mg/dl, NS) decreased after the intake. No adverse reaction was observed in a medical examination and subjective symptoms. These results demonstrate that this drinking water exhibits mild hypotensive effect in subjects with mild hypertension, and its long-term intake does not cause any adverse reaction.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"81795","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Watanabe, Kenichi"}]},{"nameIdentifiers":[{"nameIdentifier":"81796","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Inoue, Mikio"}]},{"nameIdentifiers":[{"nameIdentifier":"81797","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Nakano, Ruriko"}]},{"nameIdentifiers":[{"nameIdentifier":"81798","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Wen, Juan"}]},{"nameIdentifiers":[{"nameIdentifier":"81799","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kunizaki, Megumi"}]},{"nameIdentifiers":[{"nameIdentifier":"81800","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Mito, Sayaka"}]},{"nameIdentifiers":[{"nameIdentifier":"81801","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Meilei, Ma"}]},{"nameIdentifiers":[{"nameIdentifier":"81802","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Punniyakoti, T Veeraveedu"}]},{"nameIdentifiers":[{"nameIdentifier":"81803","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Narasimman, Gurusamy"}]},{"nameIdentifiers":[{"nameIdentifier":"81804","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Suresh, P. Selvaraj"}]},{"nameIdentifiers":[{"nameIdentifier":"81805","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Paras, Prakash"}]},{"nameIdentifiers":[{"nameIdentifier":"81806","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Wahed, Mir"}]},{"nameIdentifiers":[{"nameIdentifier":"81807","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Fadia, K. Ali"}]},{"nameIdentifiers":[{"nameIdentifier":"81808","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Reyad, A. Elbarbary"}]},{"nameIdentifiers":[{"nameIdentifier":"81809","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Behnam, Heshmatian"}]},{"nameIdentifiers":[{"nameIdentifier":"81810","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Hirayama, Masao"}]},{"nameIdentifiers":[{"nameIdentifier":"81811","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kobayashi, Takashi"}]},{"nameIdentifiers":[{"nameIdentifier":"81812","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Oyama, Hiroshi"}]},{"nameIdentifiers":[{"nameIdentifier":"81813","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kanda, Mitsuo"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"渡辺, 賢一"}],"nameIdentifiers":[{"nameIdentifier":"81776","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"井上, 幹雄"}],"nameIdentifiers":[{"nameIdentifier":"81777","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中野, るりこ"}],"nameIdentifiers":[{"nameIdentifier":"81778","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"文, 娟"}],"nameIdentifiers":[{"nameIdentifier":"81779","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"国崎, 恵"}],"nameIdentifiers":[{"nameIdentifier":"81780","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"水戸, 沙耶佳"}],"nameIdentifiers":[{"nameIdentifier":"81781","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"馬, 梅蕾"}],"nameIdentifiers":[{"nameIdentifier":"81782","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"プニヤコッテイ, Tv"}],"nameIdentifiers":[{"nameIdentifier":"81783","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ナラシマン, G"}],"nameIdentifiers":[{"nameIdentifier":"81784","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"スレシュ, Ps"}],"nameIdentifiers":[{"nameIdentifier":"81785","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"パラス, P"}],"nameIdentifiers":[{"nameIdentifier":"81786","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ワヘッド, M"}],"nameIdentifiers":[{"nameIdentifier":"81787","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ファデア, Ka"}],"nameIdentifiers":[{"nameIdentifier":"81788","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"リヤド, Ae"}],"nameIdentifiers":[{"nameIdentifier":"81789","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ベナム, H"}],"nameIdentifiers":[{"nameIdentifier":"81790","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平山, 匡男"}],"nameIdentifiers":[{"nameIdentifier":"81791","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小林, 隆司"}],"nameIdentifiers":[{"nameIdentifier":"81792","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小山, 博史"}],"nameIdentifiers":[{"nameIdentifier":"81793","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"神田, 光雄"}],"nameIdentifiers":[{"nameIdentifier":"81794","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-07"}],"displaytype":"detail","filename":"21_0005.pdf","filesize":[{"value":"877.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"21_0005.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/12173/files/21_0005.pdf"},"version_id":"3afa443b-7d4c-4e67-982e-2bd69d76cfe7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"GABA","subitem_subject_scheme":"Other"},{"subitem_subject":"リンゴ酢","subitem_subject_scheme":"Other"},{"subitem_subject":"軽症高血圧","subitem_subject_scheme":"Other"},{"subitem_subject":"健康・栄養食品","subitem_subject_scheme":"Other"},{"subitem_subject":"顆糖熟®","subitem_subject_scheme":"Other"},{"subitem_subject":"コレステロール","subitem_subject_scheme":"Other"},{"subitem_subject":"血糖","subitem_subject_scheme":"Other"},{"subitem_subject":"GABA","subitem_subject_scheme":"Other"},{"subitem_subject":"vinegar","subitem_subject_scheme":"Other"},{"subitem_subject":"mild hypertension","subitem_subject_scheme":"Other"},{"subitem_subject":"nutritional food","subitem_subject_scheme":"Other"},{"subitem_subject":"katonal®","subitem_subject_scheme":"Other"},{"subitem_subject":"cholesterol","subitem_subject_scheme":"Other"},{"subitem_subject":"blood glucose","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin 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