{"_buckets": {"deposit": "6b6e5f44-975d-445c-92ac-cc4236d951a3"}, "_deposit": {"id": "11996", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "11996"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00011996", "sets": ["456", "1011"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Enterohemorrhagic Escherichia coli Infection in Children and Its Mechanism"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2006-09", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "9", "bibliographicPageEnd": "493", "bibliographicPageStart": "485", "bibliographicVolumeNumber": "120", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "腸管出血性大腸菌(血清型O157:H7)はタイプIII分泌システムによって腸管粘膜に粘着し,溶原化したファージから志賀毒素(Stx)を産生して水様下痢や出血性大腸炎などの腹部症状を,さらに溶血性尿毒症症候群(HUS)や脳症などの重症合併症を惹起する.小児や高齢者のHUS発症は深刻で,予後不良となる.志賀毒素の作用は,蛋白合成阻害によるネクローシス,カスパーゼ活性化を介するアポトーシス,そしてIL-6,IL-8,TNF-α,IL-1βなどの炎症性サイトカイン産生の誘導で,志賀毒素サブタイプの中ではStx2が最も臨床的に強毒である.一方で,タイプIII分泌システム非依存的にHUSを発症し,死亡した小児例がわが国で発生した.原因大腸菌は,血清型O86:H-で,Stx2産生菌であった.このO86腸管出血性大腸菌は,120.73kbの粘着性プラスミドpO86Aをもち,外膜蛋白HdaA (15.5kDa)を産生して,分散型粘着(diffuse adherence)を示した.また,赤痢菌(Shigella flexneri)型のIgA1プロテアーゼ遺伝子を保有し,高い腸管免疫抵抗能力を示した.また,60.238kbの志賀毒素(Stx2)ファージを溶原化していたが,O157型ファージとは異なった独自のファージであった.当該小児例では「腸管内でO86型Stx2ファージが高定着性O86:H-大腸菌に溶原化し,新しい腸管出血性大腸菌が出現,致命的なHUSが惹起された」可能性が考えられた.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "80836", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Yamamoto, Tatsuo"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_rights_15": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "本文データは学協会の許諾に基づきCiNiiから複製したものである"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "山本, 達男"}], "nameIdentifiers": [{"nameIdentifier": "80835", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-07"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "110006483495.pdf", "filesize": [{"value": "1.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1200000.0, "url": {"label": "110006483495.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/11996/files/110006483495.pdf"}, "version_id": "474f2015-0c4d-4fec-a87d-aad219ebf3da"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "腸管出血性大腸菌感染症", "subitem_subject_scheme": "Other"}, {"subitem_subject": "O157", "subitem_subject_scheme": "Other"}, {"subitem_subject": "溶血性尿毒症症候群(HUS)", "subitem_subject_scheme": "Other"}, {"subitem_subject": "志賀毒素", "subitem_subject_scheme": "Other"}, {"subitem_subject": "新型腸管出血性大腸菌の出現", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "小児腸管出血性大腸菌感染症とその発症メカニズム", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "小児腸管出血性大腸菌感染症とその発症メカニズム"}, {"subitem_title": "小児腸管出血性大腸菌感染症とその発症メカニズム", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1011"], "permalink_uri": "http://hdl.handle.net/10191/19902", "pubdate": {"attribute_name": "公開日", "attribute_value": "2012-10-17"}, "publish_date": "2012-10-17", "publish_status": "0", "recid": "11996", "relation": {}, "relation_version_is_last": true, "title": ["小児腸管出血性大腸菌感染症とその発症メカニズム"], "weko_shared_id": null}