{"created":"2021-03-01T06:16:14.505957+00:00","id":11996,"links":{},"metadata":{"_buckets":{"deposit":"6b6e5f44-975d-445c-92ac-cc4236d951a3"},"_deposit":{"id":"11996","owners":[],"pid":{"revision_id":0,"type":"depid","value":"11996"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00011996","sets":["453:456","471:537:538:1011"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Enterohemorrhagic Escherichia coli Infection in Children and Its Mechanism"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"493","bibliographicPageStart":"485","bibliographicVolumeNumber":"120","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"腸管出血性大腸菌(血清型O157:H7)はタイプIII分泌システムによって腸管粘膜に粘着し,溶原化したファージから志賀毒素(Stx)を産生して水様下痢や出血性大腸炎などの腹部症状を,さらに溶血性尿毒症症候群(HUS)や脳症などの重症合併症を惹起する.小児や高齢者のHUS発症は深刻で,予後不良となる.志賀毒素の作用は,蛋白合成阻害によるネクローシス,カスパーゼ活性化を介するアポトーシス,そしてIL-6,IL-8,TNF-α,IL-1βなどの炎症性サイトカイン産生の誘導で,志賀毒素サブタイプの中ではStx2が最も臨床的に強毒である.一方で,タイプIII分泌システム非依存的にHUSを発症し,死亡した小児例がわが国で発生した.原因大腸菌は,血清型O86:H-で,Stx2産生菌であった.このO86腸管出血性大腸菌は,120.73kbの粘着性プラスミドpO86Aをもち,外膜蛋白HdaA (15.5kDa)を産生して,分散型粘着(diffuse adherence)を示した.また,赤痢菌(Shigella flexneri)型のIgA1プロテアーゼ遺伝子を保有し,高い腸管免疫抵抗能力を示した.また,60.238kbの志賀毒素(Stx2)ファージを溶原化していたが,O157型ファージとは異なった独自のファージであった.当該小児例では「腸管内でO86型Stx2ファージが高定着性O86:H-大腸菌に溶原化し,新しい腸管出血性大腸菌が出現,致命的なHUSが惹起された」可能性が考えられた.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"80836","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Yamamoto, Tatsuo"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"本文データは学協会の許諾に基づきCiNiiから複製したものである"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山本, 達男"}],"nameIdentifiers":[{"nameIdentifier":"80835","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-07"}],"displaytype":"detail","filename":"110006483495.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"110006483495.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/11996/files/110006483495.pdf"},"version_id":"474f2015-0c4d-4fec-a87d-aad219ebf3da"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"腸管出血性大腸菌感染症","subitem_subject_scheme":"Other"},{"subitem_subject":"O157","subitem_subject_scheme":"Other"},{"subitem_subject":"溶血性尿毒症症候群(HUS)","subitem_subject_scheme":"Other"},{"subitem_subject":"志賀毒素","subitem_subject_scheme":"Other"},{"subitem_subject":"新型腸管出血性大腸菌の出現","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"小児腸管出血性大腸菌感染症とその発症メカニズム","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"小児腸管出血性大腸菌感染症とその発症メカニズム"},{"subitem_title":"小児腸管出血性大腸菌感染症とその発症メカニズム","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1011"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-10-17"},"publish_date":"2012-10-17","publish_status":"0","recid":"11996","relation_version_is_last":true,"title":["小児腸管出血性大腸菌感染症とその発症メカニズム"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:45:04.000984+00:00"}