{"_buckets": {"deposit": "25591fe9-7734-41f2-9438-37eff6da4256"}, "_deposit": {"id": "11485", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "11485"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00011485"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "Rituximab Treatment for B-Cell Lymphoma(Molecular Targeted Therapy for Cancer)"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2007-11", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "11", "bibliographicPageEnd": "633", "bibliographicPageStart": "626", "bibliographicVolumeNumber": "121", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c"}, {"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Rituximab\u306f,\u53ef\u5909\u90e8\u9818\u57df\u304c\u30de\u30a6\u30b9\u7531\u6765,\u5b9a\u5e38\u90e8\u9818\u57df\u304c\u30d2\u30c8\u7531\u6765\u306e,\u30de\u30a6\u30b9\u30fc\u30d2\u30c8\u30ad\u30e1\u30e9\u578b\u6297CD20\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u3067\u3042\u308a,CD20\u967d\u6027B\u30ea\u30f3\u30d1\u7403\u3092\u7279\u7570\u7684\u306b\u50b7\u5bb3\u3059\u308b.1997\u5e74\u7c73\u56fd\u3067FDA\u306b\u627f\u8a8d\u3055\u308c,\u672c\u90a6\u3067\u306f2001\u5e746\u6708\u300cCD20\u967d\u6027\u4f4e\u60aa\u6027\u5ea6\u53c8\u306f\u308d\u80de\u6027\u30ea\u30f3\u30d1\u816b\u53ca\u3073\u30de\u30f3\u30c8\u30eb\u7d30\u80de\u30ea\u30f3\u30d1\u816b\u300d\u306b\u4fdd\u967a\u9069\u7528\u3068\u306a\u308a,375mg/m^2\u30921\u9031\u9593\u9593\u9694\u30674\u56de\u70b9\u6ef4\u9759\u6ce8\u3068\u3055\u308c\u305f.\u6295\u4e0e\u306b\u4f34\u3063\u3066\u767a\u73fe\u3059\u308binfusion reaction\u3092\u8efd\u6e1b\u3059\u308b\u305f\u3081,\u89e3\u71b1\u93ae\u75db\u5264\u53ca\u3073\u6297\u30d2\u30b9\u30bf\u30df\u30f3\u5264\u306e\u6295\u4e0e\u5f8c,25mg/\u6642\u304b\u3089\u6f38\u5897\u6295\u4e0e\u3059\u308b.\u300c\u518d\u767a\u30fb\u518d\u71c3\u307e\u305f\u306f\u6cbb\u7642\u62b5\u6297\u6027\u306e\u4f4e\u60aa\u6027\u5ea6\u53c8\u306f\u308d\u80de\u6027B\u7d30\u80de\u30ea\u30f3\u30d1\u816b,\u53ca\u3073\u30de\u30f3\u30c8\u30eb\u7d30\u80de\u30ea\u30f3\u30d1\u816b\u300d\u306b\u5bfe\u3059\u308b\u56fd\u5185\u81e8\u5e8a\u7b2cII\u76f8\u8a66\u9a13\u3067\u306f,\u594f\u529f\u7387\u306f\u305d\u308c\u305e\u308c61%,46%\u3067\u3042\u3063\u305f.2003\u5e749\u6708\u4fdd\u967a\u9069\u7528\u304c\u62e1\u5927\u3055\u308c,\u300cCD20\u967d\u6027\u306eB\u7d30\u80de\u6027\u975e\u30db\u30b8\u30ad\u30f3\u30ea\u30f3\u30d1\u816b\u300d\u3059\u3079\u3066\u306b\u5bfe\u3057,\u6700\u59278\u56de\u307e\u3067\u4f7f\u7528\u53ef\u80fd\u3068\u306a\u3063\u305f.GELA\u8a66\u9a13\u306f60\u301c80\u6b73\u306e\u9032\u884c\u671f,\u672a\u6cbb\u7642\u306e\u3073\u307e\u3093\u6027\u5927\u7d30\u80de\u578bB\u7d30\u80de\u30ea\u30f3\u30d1\u816b(DLBCL)\u306b\u5bfe\u3059\u308bCHOP\u7642\u6cd5\u3068,rituximab\u3092\u52a0\u3048\u305fR-CHOP\u7642\u6cd5\u3092\u6bd4\u8f03\u3057,R-CHOP\u7642\u6cd5\u304c\u7121\u30a4\u30d9\u30f3\u30c8\u751f\u5b58\u7387\u53ca\u3073\u5168\u751f\u5b58\u7387\u3067CHOP\u7642\u6cd5\u3092\u4e0a\u56de\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u305f.British Columbia\u306e\u9032\u884c\u671fDLBCL\u306e\u6cbb\u7642\u306b\u304a\u3051\u308b\u5f8c\u65b9\u8996\u7684\u6bd4\u8f03\u3067\u306f,rituximab\u306e\u4e88\u5f8c\u6539\u5584\u52b9\u679c\u306f\u9ad8\u9f62\u8005\u3060\u3051\u3067\u306a\u304f,\u82e5\u5e74\u8005\u306b\u304a\u3044\u3066\u3082\u8a8d\u3081\u3089\u308c\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f.\u308d\u80de\u6027\u30ea\u30f3\u30d1\u816b\u306f,\u81ea\u5df1\u672b\u68a2\u8840\u5e79\u7d30\u80de\u79fb\u690d\u3092\u884c\u3063\u3066\u3082\u6cbb\u7652\u56f0\u96e3\u306a\u75be\u60a3\u3067\u3042\u308a,\u5bdb\u89e3\u5f8c\u306e\u518d\u767a\u304c\u554f\u984c\u3068\u306a\u308b.EORTC\u8a66\u9a13\u3067\u306f,\u518d\u767a\u308d\u80de\u6027\u30ea\u30f3\u30d1\u816b\u3092CHOP\u307e\u305f\u306fR-CHOP\u7642\u6cd5\u3067\u6cbb\u7642\u3057,\u90e8\u5206\u5bdb\u89e3\u4ee5\u4e0a\u306e\u75c7\u4f8b\u3092rituximab\u306b\u3088\u308b\u7dad\u6301\u7642\u6cd5\u7fa4\u3068\u7121\u6cbb\u7642\u7fa4\u306b\u5272\u4ed8\u3051,\u7dad\u6301\u7642\u6cd5\u306e\u6709\u52b9\u6027\u3092\u5831\u544a\u3057\u3066\u3044\u308b.\u521d\u56de\u5bdb\u89e3\u5f8c\u306erituximab\u7dad\u6301\u7642\u6cd5\u306e\u6709\u52b9\u6027\u3092\u691c\u8a0e\u3059\u308b\u81e8\u5e8a\u8a66\u9a13\u3082\u9032\u884c\u4e2d\u3067\u3042\u308b.Rituximab\u306f\u8840\u6813\u6027\u8840\u5c0f\u677f\u6e1b\u5c11\u6027\u7d2b\u6591\u75c5(TTP)\u3084ITP,SLE\u306a\u3069\u306e\u96e3\u6cbb\u6027\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306b\u304a\u3051\u308b\u6709\u52b9\u6027\u304c\u5831\u544a\u3055\u308c,\u4fdd\u967a\u9069\u7528\u306e\u62e1\u5927\u304c\u671f\u5f85\u3055\u308c\u308b.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "77991", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Takai, Kazue"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_relation_31": {"attribute_name": "\u7570\u7248\u3067\u3042\u308b", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://ci.nii.ac.jp/naid/110007146178", "subitem_relation_type_select": "URI"}}]}, "item_7_rights_15": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\u672c\u6587\u30c7\u30fc\u30bf\u306f\u5b66\u5354\u4f1a\u306e\u8a31\u8afe\u306b\u57fa\u3065\u304dCiNii\u304b\u3089\u8907\u88fd\u3057\u305f\u3082\u306e\u3067\u3042\u308b"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u9ad8\u4e95, \u548c\u6c5f"}], "nameIdentifiers": [{"nameIdentifier": "77990", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-07"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "110007146178.pdf", "filesize": [{"value": "1.0 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1000000.0, "url": {"label": "110007146178.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/11485/files/110007146178.pdf"}, "version_id": "3483a55e-560c-45a3-8ab4-aa9d31a95492"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "rituximab", "subitem_subject_scheme": "Other"}, {"subitem_subject": "CD20", "subitem_subject_scheme": "Other"}, {"subitem_subject": "infusion reaction", "subitem_subject_scheme": "Other"}, {"subitem_subject": "B\u7d30\u80de\u30ea\u30f3\u30d1\u816b", "subitem_subject_scheme": "Other"}, {"subitem_subject": "R-CHOP\u7642\u6cd5", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "6 B\u7d30\u80de\u30ea\u30f3\u30d1\u816b\u306b\u5bfe\u3059\u308bRituximab\u6cbb\u7642(\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 \u304c\u3093\u306e\u5206\u5b50\u6a19\u7684\u6cbb\u7642, \u7b2c628\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a)", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "6 B\u7d30\u80de\u30ea\u30f3\u30d1\u816b\u306b\u5bfe\u3059\u308bRituximab\u6cbb\u7642(\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 \u304c\u3093\u306e\u5206\u5b50\u6a19\u7684\u6cbb\u7642, \u7b2c628\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a)"}, {"subitem_title": "6 B\u7d30\u80de\u30ea\u30f3\u30d1\u816b\u306b\u5bfe\u3059\u308bRituximab\u6cbb\u7642(\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 \u304c\u3093\u306e\u5206\u5b50\u6a19\u7684\u6cbb\u7642, \u7b2c628\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a)", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/997"], "permalink_uri": "http://hdl.handle.net/10191/32856", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2015-08-07"}, "publish_date": "2015-08-07", "publish_status": "0", "recid": "11485", "relation": {}, "relation_version_is_last": true, "title": ["6 B\u7d30\u80de\u30ea\u30f3\u30d1\u816b\u306b\u5bfe\u3059\u308bRituximab\u6cbb\u7642(\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 \u304c\u3093\u306e\u5206\u5b50\u6a19\u7684\u6cbb\u7642, \u7b2c628\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a)"], "weko_shared_id": null}