{"_buckets": {"deposit": "be88c5ed-2306-4024-980a-3c48ad83f043"}, "_deposit": {"id": "10618", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "10618"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00010618", "sets": ["456", "976"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Translational Research for the Establishment of Neurovasclar Protection for Ischemic Stroke"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2009-08", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "8", "bibliographicPageEnd": "393", "bibliographicPageStart": "387", "bibliographicVolumeNumber": "123", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "脳梗塞に対する血栓溶解薬 ｢組織型プラスミノダン・アクチべーター (t-PA)｣は, 1996年, 米国において｢初の本格的脳卒中治療薬｣として認められ, 以後, 世界各国でその使用が承認された. しかしながら therapeutic time window (治療可能時間) が発症後3時間以内ときわめて短く, その3時間を超えて使用した場合, 有意な改善を認めないだけでなく, 血管破綻に伴う出血性脳梗塞を合併し, 予後増悪の原因となる. これらのt-PAの問題点を克服するためには, ｢虚血性ペナンブラ｣を可能な限り維持し救出すること, そして｢虚血性血管内皮障害｣を緩和し, 出血性梗塞への進展を防止する治療的介入が必要である. すなわちt-PAと併用することで neuro-vascular protectionを可能とする薬剤を開発することがきわめて重要である.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "72603", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Shimohata, Takayoshi"}]}, {"nameIdentifiers": [{"nameIdentifier": "72604", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Kanazawa, Masato"}]}, {"nameIdentifiers": [{"nameIdentifier": "72605", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Takahashi, Tetsuya"}]}, {"nameIdentifiers": [{"nameIdentifier": "72606", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Nishizawa, Masatoyo"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "下畑, 享良"}], "nameIdentifiers": [{"nameIdentifier": "72599", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "金澤, 雅人"}], "nameIdentifiers": [{"nameIdentifier": "72600", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "高橋, 哲哉"}], "nameIdentifiers": [{"nameIdentifier": "72601", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "西澤, 正豊"}], "nameIdentifiers": [{"nameIdentifier": "72602", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "123(8)_387-393.pdf", "filesize": [{"value": "1.3 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1300000.0, "url": {"label": "123(8)_387-393.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/10618/files/123(8)_387-393.pdf"}, "version_id": "d95e4731-156a-41e8-9bf9-b59ea4ee76e8"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "脳梗塞", "subitem_subject_scheme": "Other"}, {"subitem_subject": "組織型プラスミノゲン", "subitem_subject_scheme": "Other"}, {"subitem_subject": "インヒビター", "subitem_subject_scheme": "Other"}, {"subitem_subject": "神経", "subitem_subject_scheme": "Other"}, {"subitem_subject": "血管保護", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ラット", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "脳虚血に対する神経保護療法の開発を目指して", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "脳虚血に対する神経保護療法の開発を目指して"}, {"subitem_title": "脳虚血に対する神経保護療法の開発を目指して", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "976"], "permalink_uri": "http://hdl.handle.net/10191/28466", 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