{"created":"2021-03-01T06:14:46.110947+00:00","id":10618,"links":{},"metadata":{"_buckets":{"deposit":"be88c5ed-2306-4024-980a-3c48ad83f043"},"_deposit":{"id":"10618","owners":[],"pid":{"revision_id":0,"type":"depid","value":"10618"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00010618","sets":["453:456","471:537:538:976"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Translational Research for the Establishment of Neurovasclar Protection for Ischemic Stroke"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"393","bibliographicPageStart":"387","bibliographicVolumeNumber":"123","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"脳梗塞に対する血栓溶解薬 ｢組織型プラスミノダン・アクチべーター (t-PA)｣は, 1996年, 米国において｢初の本格的脳卒中治療薬｣として認められ, 以後, 世界各国でその使用が承認された. しかしながら therapeutic time window (治療可能時間) が発症後3時間以内ときわめて短く, その3時間を超えて使用した場合, 有意な改善を認めないだけでなく, 血管破綻に伴う出血性脳梗塞を合併し, 予後増悪の原因となる. これらのt-PAの問題点を克服するためには, ｢虚血性ペナンブラ｣を可能な限り維持し救出すること, そして｢虚血性血管内皮障害｣を緩和し, 出血性梗塞への進展を防止する治療的介入が必要である. すなわちt-PAと併用することで neuro-vascular protectionを可能とする薬剤を開発することがきわめて重要である.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"72603","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Shimohata, Takayoshi"}]},{"nameIdentifiers":[{"nameIdentifier":"72604","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kanazawa, Masato"}]},{"nameIdentifiers":[{"nameIdentifier":"72605","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Takahashi, Tetsuya"}]},{"nameIdentifiers":[{"nameIdentifier":"72606","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Nishizawa, Masatoyo"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"下畑, 享良"}],"nameIdentifiers":[{"nameIdentifier":"72599","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"金澤, 雅人"}],"nameIdentifiers":[{"nameIdentifier":"72600","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高橋, 哲哉"}],"nameIdentifiers":[{"nameIdentifier":"72601","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西澤, 正豊"}],"nameIdentifiers":[{"nameIdentifier":"72602","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"123(8)_387-393.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"123(8)_387-393.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/10618/files/123(8)_387-393.pdf"},"version_id":"d95e4731-156a-41e8-9bf9-b59ea4ee76e8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"脳梗塞","subitem_subject_scheme":"Other"},{"subitem_subject":"組織型プラスミノゲン","subitem_subject_scheme":"Other"},{"subitem_subject":"インヒビター","subitem_subject_scheme":"Other"},{"subitem_subject":"神経","subitem_subject_scheme":"Other"},{"subitem_subject":"血管保護","subitem_subject_scheme":"Other"},{"subitem_subject":"ラット","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"脳虚血に対する神経保護療法の開発を目指して","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"脳虚血に対する神経保護療法の開発を目指して"},{"subitem_title":"脳虚血に対する神経保護療法の開発を目指して","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","976"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-07-22"},"publish_date":"2014-07-22","publish_status":"0","recid":"10618","relation_version_is_last":true,"title":["脳虚血に対する神経保護療法の開発を目指して"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:44:14.230896+00:00"}