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脳原発リンパ腫における免疫グロブリン遺伝子の解析
http://hdl.handle.net/10191/48348
http://hdl.handle.net/10191/483489bc7a9ca-6f6b-41b8-893f-2ebd0441ab5a
名前 / ファイル | ライセンス | アクション |
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115(8)_385-396.pdf (2.4 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2017-11-09 | |||||
タイトル | ||||||
タイトル | 脳原発リンパ腫における免疫グロブリン遺伝子の解析 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | 脳原発リンパ腫における免疫グロブリン遺伝子の解析 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Brain lymphoma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | immunoglobulin gene | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | in situ hybridization | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | somatic mutation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | on going mutation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | germinal center | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 脳原発リンパ腫 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 免疫グロブリン遺伝子 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 体細胞突然変異 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | Analysis of Immunoglobulin Gene in the Brain Lymphomas | |||||
著者 |
遠藤, 純男
× 遠藤, 純男 |
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著者別名 | ||||||
識別子 | 95256 | |||||
識別子Scheme | WEKO | |||||
姓名 | Endo, Sumio | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We examined 6 brain lymphomas, pathologically diffuse large B-cell lymphoma, for rearrangements of immunoglobulin heavy chain gene. We amplified the rearranged V_H-D-J_H sequences by RT-PCR, sequenced them, and confirmed their patient-or specimen-specificity by in situ hybridization of individual lymphoma tissues with the use of their own CDR 3 sequences as probes. In subsequent comparative nucleotide analysis and mutation analysis, we found frequent use of V_H 4 gene family (4/6 cases), in particular V 4-34 gene (3/6 cases), and, in all the 6 brain lymphomas, frequent somatic mutations (8.8-27.3%, mean 18.2%) with a significantly low frequency of R (replacement) mutations in the framework regions of V_H gene. These findings suggested that brain lymphomas are related with germinal center lymphocytes, and composed of relatively homogenous tumors in respect of immunological nature. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 115, 号 8, p. 385-396, 発行日 2001-08 |
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出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |