{"_buckets": {"deposit": "4e24b7e0-e184-4715-862b-1d21a9c3d3e9"}, "_deposit": {"id": "9703", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "9703"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00009703", "sets": ["456", "943"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Development and Programmed Cell Death of Spinal Motoneurons : What the Target Tells Us ?"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2012-05", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "5", "bibliographicPageEnd": "237", "bibliographicPageStart": "233", "bibliographicVolumeNumber": "126", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "外肺葉から分化した神経管において, 中心管近傍の神経上皮細胞から分化した運動ニューロンは前角へと移動しつつ, 標的に向かって軸索を伸長する. 標的と接触した後, 約半数の運動ニューロンは｢プログラムされた細胞死｣を起こして死ぬ. この過程は, ニューロンがその標的である筋線維からのシグナルによってコントロールされる標的由来因子依存性の生存あるいは死である. さらにアセチルコリン受容体の競合的阻害剤であるクラーレ (d-tubocurarine) の投与によってこの時期の神経筋活動を抑制すると, この細胞死は完全に抑制され, 筋肉の神経分枝が発達し, シナプス (神経筋接合部) が増加する. 従って, 脊髄運動ニューロンの形態形成を考える上で, その標的である筋の形態形成を無視することはできない. すなわち運動ニューロンとその標的である筋は一体として理解することが重要である.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "67083", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Sato, Noboru"}]}, {"nameIdentifiers": [{"nameIdentifier": "67084", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Shibata, Masahiro"}]}, {"nameIdentifiers": [{"nameIdentifier": "67085", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Yasudo, Masakuni"}]}, {"nameIdentifiers": [{"nameIdentifier": "67086", 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"運動ニューロン", "subitem_subject_scheme": "Other"}, {"subitem_subject": "骨格筋", "subitem_subject_scheme": "Other"}, {"subitem_subject": "神経筋接合部", "subitem_subject_scheme": "Other"}, {"subitem_subject": "発生", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "脊髄運動ニューロンの発生と細胞死 : その標的との関連", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "脊髄運動ニューロンの発生と細胞死 : その標的との関連"}, {"subitem_title": "脊髄運動ニューロンの発生と細胞死 : その標的との関連", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "943"], "permalink_uri": "http://hdl.handle.net/10191/31486", "pubdate": {"attribute_name": "公開日", "attribute_value": "2015-01-09"}, "publish_date": "2015-01-09", "publish_status": 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