{"created":"2021-03-01T06:13:47.727204+00:00","id":9703,"links":{},"metadata":{"_buckets":{"deposit":"4e24b7e0-e184-4715-862b-1d21a9c3d3e9"},"_deposit":{"id":"9703","owners":[],"pid":{"revision_id":0,"type":"depid","value":"9703"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00009703","sets":["453:456","471:537:538:943"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Development and Programmed Cell Death of Spinal Motoneurons : What the Target Tells Us ?"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"237","bibliographicPageStart":"233","bibliographicVolumeNumber":"126","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"外肺葉から分化した神経管において, 中心管近傍の神経上皮細胞から分化した運動ニューロンは前角へと移動しつつ, 標的に向かって軸索を伸長する. 標的と接触した後, 約半数の運動ニューロンは｢プログラムされた細胞死｣を起こして死ぬ. この過程は, ニューロンがその標的である筋線維からのシグナルによってコントロールされる標的由来因子依存性の生存あるいは死である. さらにアセチルコリン受容体の競合的阻害剤であるクラーレ (d-tubocurarine) の投与によってこの時期の神経筋活動を抑制すると, この細胞死は完全に抑制され, 筋肉の神経分枝が発達し, シナプス (神経筋接合部) が増加する. 従って, 脊髄運動ニューロンの形態形成を考える上で, その標的である筋の形態形成を無視することはできない. すなわち運動ニューロンとその標的である筋は一体として理解することが重要である.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"67083","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Sato, Noboru"}]},{"nameIdentifiers":[{"nameIdentifier":"67084","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Shibata, Masahiro"}]},{"nameIdentifiers":[{"nameIdentifier":"67085","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Yasudo, Masakuni"}]},{"nameIdentifiers":[{"nameIdentifier":"67086","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Ito, Kenjiro"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"佐藤, 昇"}],"nameIdentifiers":[{"nameIdentifier":"67079","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柴田, 昌弘"}],"nameIdentifiers":[{"nameIdentifier":"67080","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安戸, 方邦"}],"nameIdentifiers":[{"nameIdentifier":"67081","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤, 健二朗"}],"nameIdentifiers":[{"nameIdentifier":"67082","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"126(5)_233-237.pdf","filesize":[{"value":"720.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"126(5)_233-237.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/9703/files/126(5)_233-237.pdf"},"version_id":"3b75e946-6eae-43fa-82c7-b2f1a6850ad5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"運動ニューロン","subitem_subject_scheme":"Other"},{"subitem_subject":"骨格筋","subitem_subject_scheme":"Other"},{"subitem_subject":"神経筋接合部","subitem_subject_scheme":"Other"},{"subitem_subject":"発生","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"脊髄運動ニューロンの発生と細胞死 : その標的との関連","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"脊髄運動ニューロンの発生と細胞死 : その標的との関連"},{"subitem_title":"脊髄運動ニューロンの発生と細胞死 : その標的との関連","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","943"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-01-09"},"publish_date":"2015-01-09","publish_status":"0","recid":"9703","relation_version_is_last":true,"title":["脊髄運動ニューロンの発生と細胞死 : その標的との関連"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:43:40.874081+00:00"}