{"_buckets": {"deposit": "c8e0de7a-cb22-48cb-b868-e466da21af40"}, "_deposit": {"id": "9489", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "9489"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00009489"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "TDP-43 proteinopathies : Pathological Features in ALS and Other Neurodegenerative Diseases"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2012-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "12", "bibliographicPageEnd": "654", "bibliographicPageStart": "647", "bibliographicVolumeNumber": "126", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c"}, {"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Amyotrophic lateral sclerosis (ALS) is a fatal and incurable neurodegenerative disorder. One of the neuropathological hallmarks of ALS is the presence of ubiquitinated neuronal cytoplasmic inclusions (NCIs) in lower motor neurons. Recently, the 43kDa TARDNA-binding protein (TDP-43) has been identified as the major component of NCIs in sporadic ALS. While initially thought to be relatively specific to ALS and fronto-temporal lober degeneration (FTLD)-TDP, TDP-43 pathology has now been detected in a number of other neurodegenerative diseases, many associated with tau pathology, including Alzheimer\u0027s disease (AD). However, in these diseases, TDP-43 related neurodegenerative process may occur in association with other distinct pathologic processes (i.e. secondary TDP-43 proteinopathies). We recently reported TDP-43 pathology in a patient of spinocerebellar ataxia type 2 (SCA2), which is one of the polyglutamine diseases. Recently, intermediate-length polyglutamine (polyQ) expansions (27-33 Qs) in ataxin 2 (candidate gene of SCA2) is reported as a genetic risk factor for sporadic ALS. We discussed about the relations of ALS and other neurodegenerative diseases, from the pathological findings in TDP-43 proteinopathy.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "65708", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Toyoshima, Yasuko"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u8c4a\u5cf6, \u9756\u5b50"}], "nameIdentifiers": [{"nameIdentifier": "65707", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "126(12)_647-654.pdf", "filesize": [{"value": "1.4 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1400000.0, "url": {"label": "126(12)_647-654.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/9489/files/126(12)_647-654.pdf"}, "version_id": "767289ae-2ce2-462c-906c-eac594c5b093"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "amyotrophic lateral sclerosis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "TDP-43", "subitem_subject_scheme": "Other"}, {"subitem_subject": "neurodegenerative disease", "subitem_subject_scheme": "Other"}, {"subitem_subject": "polyglutamine disease", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "\u7b4b\u840e\u7e2e\u6027\u5074\u7d22\u786c\u5316\u75c7\u3068\u8fd1\u7e01\u75be\u60a3\u306e\u75c5\u7406\u6240\u898b : TDP-43 proteinopathy\u306e\u3072\u308d\u304c\u308a\u306b\u3064\u3044\u3066", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "\u7b4b\u840e\u7e2e\u6027\u5074\u7d22\u786c\u5316\u75c7\u3068\u8fd1\u7e01\u75be\u60a3\u306e\u75c5\u7406\u6240\u898b : TDP-43 proteinopathy\u306e\u3072\u308d\u304c\u308a\u306b\u3064\u3044\u3066"}, {"subitem_title": "\u7b4b\u840e\u7e2e\u6027\u5074\u7d22\u786c\u5316\u75c7\u3068\u8fd1\u7e01\u75be\u60a3\u306e\u75c5\u7406\u6240\u898b : TDP-43 proteinopathy\u306e\u3072\u308d\u304c\u308a\u306b\u3064\u3044\u3066", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/936"], "permalink_uri": "http://hdl.handle.net/10191/35477", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2015-12-11"}, "publish_date": "2015-12-11", "publish_status": "0", "recid": "9489", "relation": {}, "relation_version_is_last": true, "title": ["\u7b4b\u840e\u7e2e\u6027\u5074\u7d22\u786c\u5316\u75c7\u3068\u8fd1\u7e01\u75be\u60a3\u306e\u75c5\u7406\u6240\u898b : TDP-43 proteinopathy\u306e\u3072\u308d\u304c\u308a\u306b\u3064\u3044\u3066"], "weko_shared_id": null}