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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第126巻第12号

筋萎縮性側索硬化症と近縁疾患の病理所見 : TDP-43 proteinopathyのひろがりについて

http://hdl.handle.net/10191/35477
http://hdl.handle.net/10191/35477
5bbc3df7-39e6-49e1-8569-072d8a4685b8
名前 / ファイル ライセンス アクション
126(12)_647-654.pdf 126(12)_647-654.pdf (1.4 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-12-11
タイトル
タイトル 筋萎縮性側索硬化症と近縁疾患の病理所見 : TDP-43 proteinopathyのひろがりについて
タイトル
言語 en
タイトル 筋萎縮性側索硬化症と近縁疾患の病理所見 : TDP-43 proteinopathyのひろがりについて
言語
言語 jpn
キーワード
主題Scheme Other
主題 amyotrophic lateral sclerosis
キーワード
主題Scheme Other
主題 TDP-43
キーワード
主題Scheme Other
主題 neurodegenerative disease
キーワード
主題Scheme Other
主題 polyglutamine disease
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル TDP-43 proteinopathies : Pathological Features in ALS and Other Neurodegenerative Diseases
著者 豊島, 靖子

× 豊島, 靖子

WEKO 65707

豊島, 靖子

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著者別名
識別子 65708
識別子Scheme WEKO
姓名 Toyoshima, Yasuko
抄録
内容記述タイプ Abstract
内容記述 Amyotrophic lateral sclerosis (ALS) is a fatal and incurable neurodegenerative disorder. One of the neuropathological hallmarks of ALS is the presence of ubiquitinated neuronal cytoplasmic inclusions (NCIs) in lower motor neurons. Recently, the 43kDa TARDNA-binding protein (TDP-43) has been identified as the major component of NCIs in sporadic ALS. While initially thought to be relatively specific to ALS and fronto-temporal lober degeneration (FTLD)-TDP, TDP-43 pathology has now been detected in a number of other neurodegenerative diseases, many associated with tau pathology, including Alzheimer's disease (AD). However, in these diseases, TDP-43 related neurodegenerative process may occur in association with other distinct pathologic processes (i.e. secondary TDP-43 proteinopathies). We recently reported TDP-43 pathology in a patient of spinocerebellar ataxia type 2 (SCA2), which is one of the polyglutamine diseases. Recently, intermediate-length polyglutamine (polyQ) expansions (27-33 Qs) in ataxin 2 (candidate gene of SCA2) is reported as a genetic risk factor for sporadic ALS. We discussed about the relations of ALS and other neurodegenerative diseases, from the pathological findings in TDP-43 proteinopathy.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 126, 号 12, p. 647-654, 発行日 2012-12
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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