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筋萎縮性側索硬化症と近縁疾患の病理所見 : TDP-43 proteinopathyのひろがりについて
http://hdl.handle.net/10191/35477
http://hdl.handle.net/10191/354775bbc3df7-39e6-49e1-8569-072d8a4685b8
名前 / ファイル | ライセンス | アクション |
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126(12)_647-654.pdf (1.4 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2015-12-11 | |||||
タイトル | ||||||
タイトル | 筋萎縮性側索硬化症と近縁疾患の病理所見 : TDP-43 proteinopathyのひろがりについて | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | 筋萎縮性側索硬化症と近縁疾患の病理所見 : TDP-43 proteinopathyのひろがりについて | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | amyotrophic lateral sclerosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | TDP-43 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | neurodegenerative disease | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | polyglutamine disease | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | TDP-43 proteinopathies : Pathological Features in ALS and Other Neurodegenerative Diseases | |||||
著者 |
豊島, 靖子
× 豊島, 靖子 |
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著者別名 | ||||||
識別子 | 65708 | |||||
識別子Scheme | WEKO | |||||
姓名 | Toyoshima, Yasuko | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Amyotrophic lateral sclerosis (ALS) is a fatal and incurable neurodegenerative disorder. One of the neuropathological hallmarks of ALS is the presence of ubiquitinated neuronal cytoplasmic inclusions (NCIs) in lower motor neurons. Recently, the 43kDa TARDNA-binding protein (TDP-43) has been identified as the major component of NCIs in sporadic ALS. While initially thought to be relatively specific to ALS and fronto-temporal lober degeneration (FTLD)-TDP, TDP-43 pathology has now been detected in a number of other neurodegenerative diseases, many associated with tau pathology, including Alzheimer's disease (AD). However, in these diseases, TDP-43 related neurodegenerative process may occur in association with other distinct pathologic processes (i.e. secondary TDP-43 proteinopathies). We recently reported TDP-43 pathology in a patient of spinocerebellar ataxia type 2 (SCA2), which is one of the polyglutamine diseases. Recently, intermediate-length polyglutamine (polyQ) expansions (27-33 Qs) in ataxin 2 (candidate gene of SCA2) is reported as a genetic risk factor for sporadic ALS. We discussed about the relations of ALS and other neurodegenerative diseases, from the pathological findings in TDP-43 proteinopathy. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 126, 号 12, p. 647-654, 発行日 2012-12 |
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出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |