{"created":"2021-03-01T06:13:34.283316+00:00","id":9489,"links":{},"metadata":{"_buckets":{"deposit":"c8e0de7a-cb22-48cb-b868-e466da21af40"},"_deposit":{"id":"9489","owners":[],"pid":{"revision_id":0,"type":"depid","value":"9489"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00009489","sets":["453:456","471:537:538:936"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"TDP-43 proteinopathies : Pathological Features in ALS and Other Neurodegenerative Diseases"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"654","bibliographicPageStart":"647","bibliographicVolumeNumber":"126","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Amyotrophic lateral sclerosis (ALS) is a fatal and incurable neurodegenerative disorder. One of the neuropathological hallmarks of ALS is the presence of ubiquitinated neuronal cytoplasmic inclusions (NCIs) in lower motor neurons. Recently, the 43kDa TARDNA-binding protein (TDP-43) has been identified as the major component of NCIs in sporadic ALS. While initially thought to be relatively specific to ALS and fronto-temporal lober degeneration (FTLD)-TDP, TDP-43 pathology has now been detected in a number of other neurodegenerative diseases, many associated with tau pathology, including Alzheimer's disease (AD). However, in these diseases, TDP-43 related neurodegenerative process may occur in association with other distinct pathologic processes (i.e. secondary TDP-43 proteinopathies). We recently reported TDP-43 pathology in a patient of spinocerebellar ataxia type 2 (SCA2), which is one of the polyglutamine diseases. Recently, intermediate-length polyglutamine (polyQ) expansions (27-33 Qs) in ataxin 2 (candidate gene of SCA2) is reported as a genetic risk factor for sporadic ALS. We discussed about the relations of ALS and other neurodegenerative diseases, from the pathological findings in TDP-43 proteinopathy.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"65708","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Toyoshima, Yasuko"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"豊島, 靖子"}],"nameIdentifiers":[{"nameIdentifier":"65707","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"126(12)_647-654.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"126(12)_647-654.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/9489/files/126(12)_647-654.pdf"},"version_id":"767289ae-2ce2-462c-906c-eac594c5b093"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"amyotrophic lateral sclerosis","subitem_subject_scheme":"Other"},{"subitem_subject":"TDP-43","subitem_subject_scheme":"Other"},{"subitem_subject":"neurodegenerative disease","subitem_subject_scheme":"Other"},{"subitem_subject":"polyglutamine disease","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"筋萎縮性側索硬化症と近縁疾患の病理所見 : TDP-43 proteinopathyのひろがりについて","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"筋萎縮性側索硬化症と近縁疾患の病理所見 : TDP-43 proteinopathyのひろがりについて"},{"subitem_title":"筋萎縮性側索硬化症と近縁疾患の病理所見 : TDP-43 proteinopathyのひろがりについて","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","936"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-12-11"},"publish_date":"2015-12-11","publish_status":"0","recid":"9489","relation_version_is_last":true,"title":["筋萎縮性側索硬化症と近縁疾患の病理所見 : TDP-43 proteinopathyのひろがりについて"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:43:33.372198+00:00"}