{"_buckets": {"deposit": "a7fce449-0222-4764-adc6-229f207f4d79"}, "_deposit": {"id": "8228", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "8228"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00008228"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "Preoperative Chemotherapy for Colorectal Carcinoma Liver Metastasis : Impact of NQO1 Expression on Prediction of Therapeutic Effect"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2017-08", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "8", "bibliographicPageEnd": "500", "bibliographicPageStart": "491", "bibliographicVolumeNumber": "131", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c"}, {"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "\u3010\u7dd2\u8a00\u3011\u8fd1\u5e74\u306e\u5927\u8178\u764c\u306b\u5bfe\u3059\u308b\u5316\u5b66\u7642\u6cd5\u306e\u9032\u6b69\u3092\u80cc\u666f\u3068\u3057\u3066\u5927\u8178\u764c\u809d\u8ee2\u79fb\u306b\u5bfe\u3057\u3066\u8853\u524d\u5316\u5b66\u7642\u6cd5\u3092\u5b9f\u65bd\u3059\u308b\u6a5f\u4f1a\u304c\u5897\u3048\u3064\u3064\u3042\u308a\uff0c\u5927\u8178\u764c\u809d\u8ee2\u79fb\u306b\u5bfe\u3059\u308b\u8853\u524d\u5316\u5b66\u7642\u6cd5\u306e\u6cbb\u7642\u52b9\u679c\u3092\u4e88\u6e2c\u3059\u308b\u3053\u3068\u306f\u81e8\u5e8a\u4e0a\uff0c\u91cd\u8981\u306a\u8ab2\u984c\u3068\u306a\u3063\u3066\u3044\u308b\uff0e\u6297\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u86cb\u767d\u3067\u3042\u308bNAD (P) H : quinone oxidoreductase-1 (NQO1)\u306f\u7a2e\u3005\u306e\u764c\u816b\u3067\u5316\u5b66\u7642\u6cd5\u306b\u5bfe\u3059\u308b\u611f\u53d7\u6027\u3068\u306e\u95a2\u9023\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\uff0e\u672c\u7814\u7a76\u3067\u306f\uff0cNQO1\u767a\u73fe\u304c\u5927\u8178\u764c\u809d\u8ee2\u79fb\u306b\u5bfe\u3059\u308b\u8853\u524d\u5316\u5b66\u7642\u6cd5\u306e\u6cbb\u7642\u52b9\u679c\u4e88\u6e2c\u56e0\u5b50\u3068\u306a\u308a\u5f97\u308b\u304b\u5426\u304b\u3092\u8a55\u4fa1\u3059\u308b\uff0e\u3010\u5bfe\u8c61\u3068\u65b9\u6cd5\u3011\u5f53\u79d1\u3067\u8853\u524d\u5316\u5b66\u7642\u6cd5\u5b9f\u65bd\u5f8c\u306b\u521d\u56de\u809d\u5207\u9664\u304c\u65bd\u884c\u3055\u308c\u305f\u5927\u8178\u764c\u809d\u8ee2\u79fb23\u4f8b\u3092\u5bfe\u8c61\u3068\u3057\u305f\uff0e\u8853\u524d\u5316\u5b66\u7642\u6cd5\u306e\u6cbb\u7642\u52b9\u679c\u306f\uff0c\u809d\u5207\u9664\u524d\u306bRECIST(version 1.1)\u3067\u5224\u5b9a\u3059\u308b\u3068\u3068\u3082\u306b\uff0c\u5207\u9664\u6a19\u672c\u3067\u5927\u8178\u764c\u53d6\u6271\u3044\u898f\u7d04\u7b2c8\u7248\u306b\u5f93\u3063\u3066\u7d44\u7e54\u5b66\u7684\u306b\u5224\u5b9a\u3057\u305f\uff0eNQO1\u767a\u73fe\u306e\u6709\u7121\u306f\uff0c\u5207\u9664\u6a19\u672c\u3067NQO1\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u3092\u7528\u3044\u305f\u514d\u75ab\u7d44\u7e54\u5316\u5b66\u3092\u884c\u3046\u3053\u3068\u3067\u540c\u5b9a\u3057\u305f\uff0e\u809d\u8ee2\u79fb\u5de3\u306e\u816b\u760d\u7d30\u80de\u304cNQO1\u767a\u73fe\u9670\u6027\u3092\u793a\u3059\u5834\u5408\uff0c\u540c\u4e00\u6a19\u672c\u5185\u306e\u975e\u816b\u760d\u6027\u5927\u578b\u80c6\u7ba1\u4e0a\u76ae\u7d30\u80de\u3082NQO1\u767a\u73fe\u9670\u6027\u3067\u3042\u308c\u3070NQO1\u907a\u4f1d\u5b50\u591a\u578b\u3042\u308a\u3068\u5224\u5b9a\u3057\u305f\uff0e\u3010\u7d50\u679c\u301123\u4f8b\u306b\u304a\u3051\u308b\u8853\u524d\u5316\u5b66\u7642\u6cd5\u306eRECIST\u306b\u3088\u308b\u6cbb\u7642\u52b9\u679c\u5224\u5b9a\u306f\uff0cPR(Partial Response: \u90e8\u5206\u594f\u52b9)\u304c14\u4f8b\uff0cSD(Stable Disease: \u5b89\u5b9a)\u304c8\u4f8b\uff0cPD(Progressive Disease: \u9032\u884c)\u304c1\u4f8b\u3067\u3042\u308a\uff0c\u594f\u52b9\u7387\u306f61%\u3067\u3042\u3063\u305f\uff0e\u8853\u524d\u5316\u5b66\u7642\u6cd5\u306e\u7d44\u7e54\u5b66\u7684\u306a\u6cbb\u7642\u52b9\u679c\u5224\u5b9a\u306f\uff0cGrade 0\u304c3\u4f8b\uff0cGrade 1\u304c9\u4f8b\uff0cGrade 2\u304c11\u4f8b\u3067\u3042\u3063\u305f\uff0e23\u75c7\u4f8b\u4e2d15\u4f8b(65%)\u304c\u8089\u773c\u7684\u809d\u8ee2\u79fb\u5de3\u306b\u304a\u3051\u308bNQO1\u767a\u73fe\u967d\u6027\u3067\u3042\u308a\uff0c8\u4f8b(35%)\u304cNQO1\u767a\u73fe\u9670\u6027\u3067\u3042\u3063\u305f\uff0eNQO1\u767a\u73fe\u9670\u6027\u306e8\u4f8b\u4e2d\uff0c\u975e\u816b\u760d\u6027\u5927\u578b\u80c6\u7ba1\u4e0a\u76ae\u7d30\u80de\u304cNQO1\u767a\u73fe\u9670\u6027\u3092\u793a\u3059NQO1\u907a\u4f1d\u5b50\u591a\u578b\u304c6\u4f8b\u3067\u8a8d\u3081\u3089\u308c\u305f\uff0e\u8089\u773c\u7684\u809d\u8ee2\u79fb\u5de3\u306eNQO1\u767a\u73fe\u306e\u6709\u7121\u3068\u8853\u524d\u5316\u5b66\u7642\u6cd5\u306eRECIST\u304a\u3088\u3073\u7d44\u7e54\u5b66\u7684\u6cbb\u7642\u52b9\u679c\u5224\u5b9a\u3068\u306e\u9593\u306b\u660e\u3089\u304b\u306a\u95a2\u9023\u3092\u8a8d\u3081\u306a\u304b\u3063\u305f(\u5404\u3005\uff0cP=0.400\uff0cP=0.193)\uff0e\u4e00\u65b9\uff0cNQO1\u907a\u4f1d\u5b50\u591a\u578b\u306e\u6709\u7121\u3068\u8853\u524d\u5316\u5b66\u7642\u6cd5\u306eRECIST\u306b\u3088\u308b\u6cbb\u7642\u52b9\u679c\u5224\u5b9a\u3068\u306e\u95a2\u9023\u3092\u691c\u8a0e\u3059\u308b\u3068\uff0cNQO1\u907a\u4f1d\u5b50\u591a\u578b\u3092\u8a8d\u3081\u305f6\u4f8b\u5168\u4f8b\u304cPR\u3092\u793a\u3057\u305f\u306e\u306b\u5bfe\u3057\uff0cNQO1\u907a\u4f1d\u5b50\u591a\u578b\u3092\u8a8d\u3081\u306a\u304b\u3063\u305f17\u4f8b\u3067\u306f8\u4f8b(47%)\u304cPR\u3067\u3042\u308a\uff0cNQO1\u907a\u4f1d\u5b50\u591a\u578b\u306b\u3088\u308aNQO1\u767a\u73fe\u9670\u6027\u306e\u75c7\u4f8b\u3067\u306f\u6709\u610f\u306b\u594f\u52b9\u7387\u304c\u9ad8\u304b\u3063\u305f(P=0.048)\uff0e\u3010\u7d50\u8a9e\u3011NQO1\u304c\u907a\u4f1d\u5b50\u591a\u578b\u306b\u3088\u308a\u767a\u73fe\u3057\u3066\u3044\u306a\u3044\u5927\u8178\u764c\u809d\u8ee2\u79fb\u75c7\u4f8b\u306f\u5316\u5b66\u7642\u6cd5\u306b\u5bfe\u3059\u308b\u611f\u53d7\u6027\u304c\u9ad8\u304f\uff0cNQO1\u907a\u4f1d\u5b50\u591a\u578b\u306f\u5927\u8178\u764c\u809d\u8ee2\u79fb\u306b\u5bfe\u3059\u308b\u8853\u524d\u5316\u5b66\u7642\u6cd5\u306e\u6cbb\u7642\u52b9\u679c\u3092\u4e88\u6e2c\u3059\u308b\u6709\u671b\u306a\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306e\u5019\u88dc\u306e1\u3064\u3067\u3042\u308b\uff0e", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "57753", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Soma, Daiki"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u76f8\u99ac, \u5927\u8f1d"}], "nameIdentifiers": [{"nameIdentifier": "57752", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "131(8)_491-500.pdf", "filesize": [{"value": "4.0 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 4000000.0, "url": {"label": "131(8)_491-500.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/8228/files/131(8)_491-500.pdf"}, "version_id": "cc523adf-9117-4f1d-9097-f9726b7ddd21"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "\u5927\u8178\u764c\u809d\u8ee2\u79fb", "subitem_subject_scheme": "Other"}, {"subitem_subject": "NAD (P) H : quinone oxidoreductase-1", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u8853\u524d\u5316\u5b66\u7642\u6cd5", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u809d\u5185\u5fae\u5c0f\u8ee2\u79fb\u5de3", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u809d\u5207\u9664", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "\u5927\u8178\u764c\u809d\u8ee2\u79fb\u306b\u5bfe\u3059\u308b\u8853\u524d\u5316\u5b66\u7642\u6cd5 : NQO1\u767a\u73fe\u3092\u7528\u3044\u305f\u6cbb\u7642\u52b9\u679c\u4e88\u6e2c\u306e\u53ef\u80fd\u6027", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "\u5927\u8178\u764c\u809d\u8ee2\u79fb\u306b\u5bfe\u3059\u308b\u8853\u524d\u5316\u5b66\u7642\u6cd5 : NQO1\u767a\u73fe\u3092\u7528\u3044\u305f\u6cbb\u7642\u52b9\u679c\u4e88\u6e2c\u306e\u53ef\u80fd\u6027"}, {"subitem_title": "\u5927\u8178\u764c\u809d\u8ee2\u79fb\u306b\u5bfe\u3059\u308b\u8853\u524d\u5316\u5b66\u7642\u6cd5 : NQO1\u767a\u73fe\u3092\u7528\u3044\u305f\u6cbb\u7642\u52b9\u679c\u4e88\u6e2c\u306e\u53ef\u80fd\u6027", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/884"], "permalink_uri": "http://hdl.handle.net/10191/49654", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2018-02-28"}, "publish_date": "2018-02-28", "publish_status": "0", "recid": "8228", "relation": {}, "relation_version_is_last": true, "title": ["\u5927\u8178\u764c\u809d\u8ee2\u79fb\u306b\u5bfe\u3059\u308b\u8853\u524d\u5316\u5b66\u7642\u6cd5 : NQO1\u767a\u73fe\u3092\u7528\u3044\u305f\u6cbb\u7642\u52b9\u679c\u4e88\u6e2c\u306e\u53ef\u80fd\u6027"], "weko_shared_id": null}