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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.33 No.3

Studies on the effect of administration of DDAVP in patients with cerebrovascular occlusive diseases from the viewpoint of blood coagulation-fibrinolysis in vessel walls

http://hdl.handle.net/10191/33622
http://hdl.handle.net/10191/33622
062c0317-0178-47ee-9928-3004666c9f01
名前 / ファイル ライセンス アクション
33(3)_151-162.pdf 33(3)_151-162.pdf (852.9 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-10-09
タイトル
タイトル Studies on the effect of administration of DDAVP in patients with cerebrovascular occlusive diseases from the viewpoint of blood coagulation-fibrinolysis in vessel walls
タイトル
言語 en
タイトル Studies on the effect of administration of DDAVP in patients with cerebrovascular occlusive diseases from the viewpoint of blood coagulation-fibrinolysis in vessel walls
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 Arai, Hiroyuki

× Arai, Hiroyuki

WEKO 54001

Arai, Hiroyuki

Search repository
Miyakawa, Teruo

× Miyakawa, Teruo

WEKO 54002

Miyakawa, Teruo

Search repository
Sakuragawa, Nobuo

× Sakuragawa, Nobuo

WEKO 54003

Sakuragawa, Nobuo

Search repository
抄録
内容記述タイプ Abstract
内容記述 To clarify the pathogenesis of cerebral thrombosis and to estimate the effectiveness of fibrinolytic treatment by administration of urokinase from the viewpoint of coagulation-fibrinolysis in vessel walls, changes of blood coagulation were investigated by intravenous administration of 1-deamino-8-D-arginine vasopressin (DDAVP) to 10 healthy volunteers and to 14 patients with cerebrovascular occlusive diseases. Results were as follows: 1) After the administration of DDAVP to normal controls, aPTT was shortened, PT was not changed, factor VIII:C and factor VIIIR:Ag were increased, euglobulin lysis time was shortened, plasminogen activator was increased, α_2-plasmin inhibitor was decreased, and no changes of antithrombin III were observed. Increases in factor VIII:C and factor VIIIR:Ag were more prominent in the elder group. Coagulation-fibrinolytic changes were more marked after the administration of 8 μg of DDAVP than those after the administration of 4 μg DDAVP. 2) Activities of coagulation were higher and activities of fibrinolysis and release activity of plasminogen activator were lower in patients with severe cerebral arteriosclerosis than in patients with mild cerebral arteriosclerosis. Plasminogen activator was markedly increased in patients with mild cerebral arteriosclerosis, whereas a very slight increase was observed in patients with severe cerebral arteriosclerosis. 3) Plasminogen activator showed higher levels in the patients in whom urokinase therapy had been effective to recanalize the occluded cerebral artery than in those with no recanalization by urokinase therapy. One of the recanalized patients showed a remarkable increase in plasminogen activator after the administration of DDAVP.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 33, 号 3, p. 151-162, 発行日 1985-12
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
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