@article{oai:niigata-u.repo.nii.ac.jp:00006702,
 author = {Arai, Hiroyuki and Miyakawa, Teruo and Sakuragawa, Nobuo},
 issue = {3},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Dec},
 note = {To clarify the pathogenesis of cerebral thrombosis and to estimate the effectiveness of fibrinolytic treatment by administration of urokinase from the viewpoint of coagulation-fibrinolysis in vessel walls, changes of blood coagulation were investigated by intravenous administration of 1-deamino-8-D-arginine vasopressin (DDAVP) to 10 healthy volunteers and to 14 patients with cerebrovascular occlusive diseases. Results were as follows: 1) After the administration of DDAVP to normal controls, aPTT was shortened, PT was not changed, factor VIII:C and factor VIIIR:Ag were increased, euglobulin lysis time was shortened, plasminogen activator was increased, α_2-plasmin inhibitor was decreased, and no changes of antithrombin III were observed. Increases in factor VIII:C and factor VIIIR:Ag were more prominent in the elder group. Coagulation-fibrinolytic changes were more marked after the administration of 8 μg of DDAVP than those after the administration of 4 μg DDAVP. 2) Activities of coagulation were higher and activities of fibrinolysis and release activity of plasminogen activator were lower in patients with severe cerebral arteriosclerosis than in patients with mild cerebral arteriosclerosis. Plasminogen activator was markedly increased in patients with mild cerebral arteriosclerosis, whereas a very slight increase was observed in patients with severe cerebral arteriosclerosis. 3) Plasminogen activator showed higher levels in the patients in whom urokinase therapy had been effective to recanalize the occluded cerebral artery than in those with no recanalization by urokinase therapy. One of the recanalized patients showed a remarkable increase in plasminogen activator after the administration of DDAVP.},
 pages = {151--162},
 title = {Studies on the effect of administration of DDAVP in patients with cerebrovascular occlusive diseases from the viewpoint of blood coagulation-fibrinolysis in vessel walls},
 volume = {33},
 year = {1985}
}