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The nucleotide sequence of a 1.8 Kb fragment of two allelic genes, H-2D^p and H-2D^d, encoding the mouse histocompatibility antigens
http://hdl.handle.net/10191/33604
http://hdl.handle.net/10191/336042f0ddbd9-bebd-4f0c-a96f-b262f0a9f169
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2015-10-08 | |||||
タイトル | ||||||
タイトル | The nucleotide sequence of a 1.8 Kb fragment of two allelic genes, H-2D^p and H-2D^d, encoding the mouse histocompatibility antigens | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | The nucleotide sequence of a 1.8 Kb fragment of two allelic genes, H-2D^p and H-2D^d, encoding the mouse histocompatibility antigens | |||||
言語 | ||||||
言語 | eng | |||||
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資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
著者 |
Takahashi, Hiroaki
× Takahashi, Hiroaki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The nucleotide sequence of the genes encoding the 5'-portion of H-2D^p and H-2D^d molecules was determined. A 1.8 Kb XbaI fragment was isolated from two different libraries and its sequence determined by the dideoxy and chemical cleavage methods. The H-2D^p XbaI fragment consists of 1,837 nucleotides and includes the 5'-flanking region, the L, N, and Cl domain coding regions and intron 1, 2 and 3. The H-2D^d clone is of similar length and includes comparable regions of the gene. The D^d sequence, with the exception of three nucleotide substitutions, was identical to the published sequence of pAG64, a cDNA clone obtained from a SV40 transformed 3T3 cell line (5). Comparison of the nucleotide sequences of the D^p and D^d gene fragment reveals a high degree of homology (92%). Further comparisons of the D^p and D^d sequences with other previously published classI gene sequences reveals that the homology between D^p and D^d is higher than the homology of either of these genes to D^b, L^d, K^b or K^d. The small differences in the 5'-portion of D^p and D^d gene are up to three nucleotides. This comparison suggests these genes have diverged by the accumulation of point mutation as well as by gene conversion. | |||||
書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 34, 号 4, p. 117-128, 発行日 1987-03 |
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出版者 | Niigata University School of Medicine | |||||
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収録物識別子タイプ | ISSN | |||||
収録物識別子 | 05677734 | |||||
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収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508361 | |||||
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値 | publisher |