{"_buckets": {"deposit": "14417677-ebd5-444a-b79e-a5b2daac4f0c"}, "_deposit": {"id": "6680", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6680"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006680"}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1987-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "116", "bibliographicPageStart": "111", "bibliographicVolumeNumber": "34", "bibliographic_titles": [{"bibliographic_title": "Acta medica et biologica"}, {"bibliographic_title": "Acta medica et biologica", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "6-Mercaptopurine (6-MP) resistant strains of L1210 v/c murine leukemic cells were obtained in vivo 6-MP treatment of a DBA/2 mouse inoculated with sensitive L1210 cells. In one of these 6-MP resistant strains, double minutes (DMs) were found in 12% of the metaphase cells, the number of DMs per cell ranging from 5 to 20. When these 6-MP resistant cells were subcultured in 6-MP free medium for 20 months, only 2% of the cells had DMs ranging from 1 to 5 per cell. The decrease of DMs in number and appearance rate was accompanied by a lowering of the maximum allowable concentration (MAC) of 6-MP necessary to induce resistance in the cells from 1 \u03bcg to 0.1 \u03bcg/ml. These observations suggest that 6-MP resistance in L1210 cells is the result of an unknown gene amplification.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Niigata University School of Medicine"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508361", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05677734", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Kato, Chihomi"}], "nameIdentifiers": [{"nameIdentifier": "53922", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Natsuno, Tetsuya"}], "nameIdentifiers": [{"nameIdentifier": "53923", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Saito, Kazuko"}], "nameIdentifiers": [{"nameIdentifier": "53924", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "34(4)_111-116.pdf", "filesize": [{"value": "912.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 912000.0, "url": {"label": "34(4)_111-116.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/6680/files/34(4)_111-116.pdf"}, "version_id": "3437d47d-46c9-494e-9849-dbba093c0406"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Double minute chromosomes in a 6-MP resistant mouse leukemia L1210 cell line", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Double minute chromosomes in a 6-MP resistant mouse leukemia L1210 cell line"}, {"subitem_title": "Double minute chromosomes in a 6-MP resistant mouse leukemia L1210 cell line", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/568/657"], "permalink_uri": "http://hdl.handle.net/10191/33603", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2015-10-08"}, "publish_date": "2015-10-08", "publish_status": "0", "recid": "6680", "relation": {}, "relation_version_is_last": true, "title": ["Double minute chromosomes in a 6-MP resistant mouse leukemia L1210 cell line"], "weko_shared_id": null}