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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.34 No.4

Double minute chromosomes in a 6-MP resistant mouse leukemia L1210 cell line

http://hdl.handle.net/10191/33603
http://hdl.handle.net/10191/33603
93e07917-6857-4795-9c6f-4d858831ed47
名前 / ファイル ライセンス アクション
34(4)_111-116.pdf 34(4)_111-116.pdf (912.0 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-10-08
タイトル
タイトル Double minute chromosomes in a 6-MP resistant mouse leukemia L1210 cell line
タイトル
言語 en
タイトル Double minute chromosomes in a 6-MP resistant mouse leukemia L1210 cell line
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 Kato, Chihomi

× Kato, Chihomi

WEKO 53922

Kato, Chihomi

Search repository
Natsuno, Tetsuya

× Natsuno, Tetsuya

WEKO 53923

Natsuno, Tetsuya

Search repository
Saito, Kazuko

× Saito, Kazuko

WEKO 53924

Saito, Kazuko

Search repository
抄録
内容記述タイプ Abstract
内容記述 6-Mercaptopurine (6-MP) resistant strains of L1210 v/c murine leukemic cells were obtained in vivo 6-MP treatment of a DBA/2 mouse inoculated with sensitive L1210 cells. In one of these 6-MP resistant strains, double minutes (DMs) were found in 12% of the metaphase cells, the number of DMs per cell ranging from 5 to 20. When these 6-MP resistant cells were subcultured in 6-MP free medium for 20 months, only 2% of the cells had DMs ranging from 1 to 5 per cell. The decrease of DMs in number and appearance rate was accompanied by a lowering of the maximum allowable concentration (MAC) of 6-MP necessary to induce resistance in the cells from 1 μg to 0.1 μg/ml. These observations suggest that 6-MP resistance in L1210 cells is the result of an unknown gene amplification.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 34, 号 4, p. 111-116, 発行日 1987-03
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
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