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Double minute chromosomes in a 6-MP resistant mouse leukemia L1210 cell line
http://hdl.handle.net/10191/33603
http://hdl.handle.net/10191/3360393e07917-6857-4795-9c6f-4d858831ed47
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2015-10-08 | |||||
タイトル | ||||||
タイトル | Double minute chromosomes in a 6-MP resistant mouse leukemia L1210 cell line | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Double minute chromosomes in a 6-MP resistant mouse leukemia L1210 cell line | |||||
言語 | ||||||
言語 | eng | |||||
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資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
著者 |
Kato, Chihomi
× Kato, Chihomi× Natsuno, Tetsuya× Saito, Kazuko |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 6-Mercaptopurine (6-MP) resistant strains of L1210 v/c murine leukemic cells were obtained in vivo 6-MP treatment of a DBA/2 mouse inoculated with sensitive L1210 cells. In one of these 6-MP resistant strains, double minutes (DMs) were found in 12% of the metaphase cells, the number of DMs per cell ranging from 5 to 20. When these 6-MP resistant cells were subcultured in 6-MP free medium for 20 months, only 2% of the cells had DMs ranging from 1 to 5 per cell. The decrease of DMs in number and appearance rate was accompanied by a lowering of the maximum allowable concentration (MAC) of 6-MP necessary to induce resistance in the cells from 1 μg to 0.1 μg/ml. These observations suggest that 6-MP resistance in L1210 cells is the result of an unknown gene amplification. | |||||
書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 34, 号 4, p. 111-116, 発行日 1987-03 |
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出版者 | Niigata University School of Medicine | |||||
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収録物識別子タイプ | ISSN | |||||
収録物識別子 | 05677734 | |||||
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収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508361 | |||||
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値 | publisher |