WEKO3
-
RootNode
アイテム
Double minute chromosomes in a 6-MP resistant mouse leukemia L1210 cell line
http://hdl.handle.net/10191/33603
http://hdl.handle.net/10191/3360393e07917-6857-4795-9c6f-4d858831ed47
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
34(4)_111-116.pdf (912.0 kB)
|
|
| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-10-08 | |||||
| タイトル | ||||||
| タイトル | Double minute chromosomes in a 6-MP resistant mouse leukemia L1210 cell line | |||||
| タイトル | ||||||
| タイトル | Double minute chromosomes in a 6-MP resistant mouse leukemia L1210 cell line | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 著者 |
Kato, Chihomi
× Kato, Chihomi× Natsuno, Tetsuya× Saito, Kazuko |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | 6-Mercaptopurine (6-MP) resistant strains of L1210 v/c murine leukemic cells were obtained in vivo 6-MP treatment of a DBA/2 mouse inoculated with sensitive L1210 cells. In one of these 6-MP resistant strains, double minutes (DMs) were found in 12% of the metaphase cells, the number of DMs per cell ranging from 5 to 20. When these 6-MP resistant cells were subcultured in 6-MP free medium for 20 months, only 2% of the cells had DMs ranging from 1 to 5 per cell. The decrease of DMs in number and appearance rate was accompanied by a lowering of the maximum allowable concentration (MAC) of 6-MP necessary to induce resistance in the cells from 1 μg to 0.1 μg/ml. These observations suggest that 6-MP resistance in L1210 cells is the result of an unknown gene amplification. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 34, 号 4, p. 111-116, 発行日 1987-03 |
|||||
| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
Share
Cite as
Kato, Chihomi, Natsuno, Tetsuya, Saito, Kazuko, 1987, Double minute chromosomes in a 6-MP resistant mouse leukemia L1210 cell line: Niigata University School of Medicine, 111–116 p.
Loading...
