{"created":"2021-03-01T06:10:35.947174+00:00","id":6680,"links":{},"metadata":{"_buckets":{"deposit":"14417677-ebd5-444a-b79e-a5b2daac4f0c"},"_deposit":{"id":"6680","owners":[],"pid":{"revision_id":0,"type":"depid","value":"6680"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00006680","sets":["453:456","471:537:568:657"]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1987-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"116","bibliographicPageStart":"111","bibliographicVolumeNumber":"34","bibliographic_titles":[{"bibliographic_title":"Acta medica et biologica"},{"bibliographic_title":"Acta medica et biologica","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"6-Mercaptopurine (6-MP) resistant strains of L1210 v/c murine leukemic cells were obtained in vivo 6-MP treatment of a DBA/2 mouse inoculated with sensitive L1210 cells. In one of these 6-MP resistant strains, double minutes (DMs) were found in 12% of the metaphase cells, the number of DMs per cell ranging from 5 to 20. When these 6-MP resistant cells were subcultured in 6-MP free medium for 20 months, only 2% of the cells had DMs ranging from 1 to 5 per cell. The decrease of DMs in number and appearance rate was accompanied by a lowering of the maximum allowable concentration (MAC) of 6-MP necessary to induce resistance in the cells from 1 μg to 0.1 μg/ml. These observations suggest that 6-MP resistance in L1210 cells is the result of an unknown gene amplification.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Niigata University School of Medicine"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508361","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05677734","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kato, Chihomi"}],"nameIdentifiers":[{"nameIdentifier":"53922","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Natsuno, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"53923","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saito, Kazuko"}],"nameIdentifiers":[{"nameIdentifier":"53924","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"34(4)_111-116.pdf","filesize":[{"value":"912.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"34(4)_111-116.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/6680/files/34(4)_111-116.pdf"},"version_id":"3437d47d-46c9-494e-9849-dbba093c0406"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Double minute chromosomes in a 6-MP resistant mouse leukemia L1210 cell line","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Double minute chromosomes in a 6-MP resistant mouse leukemia L1210 cell line"},{"subitem_title":"Double minute chromosomes in a 6-MP resistant mouse leukemia L1210 cell line","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","657"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-10-08"},"publish_date":"2015-10-08","publish_status":"0","recid":"6680","relation_version_is_last":true,"title":["Double minute chromosomes in a 6-MP resistant mouse leukemia L1210 cell line"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:39:59.696642+00:00"}