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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.37 No.1

Possible Mechanism of GRP (Gastrin-Releasing Peptide)-Containing Nerves Regulating the Mucosal Microcirculation in the Rat Gastric Body

http://hdl.handle.net/10191/33535
http://hdl.handle.net/10191/33535
51227ce5-dd12-4f92-8ee2-e3ca06086278
名前 / ファイル ライセンス アクション
37(1)_35-43.pdf 37(1)_35-43.pdf (4.3 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-10-06
タイトル
タイトル Possible Mechanism of GRP (Gastrin-Releasing Peptide)-Containing Nerves Regulating the Mucosal Microcirculation in the Rat Gastric Body
タイトル
言語 en
タイトル Possible Mechanism of GRP (Gastrin-Releasing Peptide)-Containing Nerves Regulating the Mucosal Microcirculation in the Rat Gastric Body
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 Iwanaga, T.

× Iwanaga, T.

WEKO 53828

Iwanaga, T.

Search repository
Takahashi-Iwanaga, H.

× Takahashi-Iwanaga, H.

WEKO 53829

Takahashi-Iwanaga, H.

Search repository
Fujita, T.

× Fujita, T.

WEKO 53830

Fujita, T.

Search repository
抄録
内容記述タイプ Abstract
内容記述 GRP (gastrin-releasing peptide)-containing nerves are most densely distributed in the gastric body throughout the gut. We previously found a marked decrease of GRP-immunoreactivity from nerve fibers in the oxyntic mucosa with stress-induced ulcers. The unusual release of GRP from the nerves under stress conditions seems to cause acute mucosal erosions. Since GRP has an action of vasoconstriction which may be responsible for the genesis of ulcers, the present study focuses on the relationship of GRP nerves and blood vessels. The GRP-immunopositive nerves were found to run close to the blood vessels throughout the mucosa. Scanning and transmission electron microscope observations showed that the nerve bundles containing GRP fibers were topographically associated with capillaries, but not with any glandular cells. The oxyntic mucosa is supplied exclusively by capillaries without smooth muscles which may respond to GRP. However, the capillaries here were accompanied by pericytes which reportedly are contractile in nature. Pericytes were frequently found intervening between the capillaries and nerves. The present finding suggests a possibility that GRP released from nerves reduces mucosal blood flow via the contraction of pericytes, finally causing mucosal ischemia and damage.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 37, 号 1, p. 35-43, 発行日 1989-06
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
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