@article{oai:niigata-u.repo.nii.ac.jp:00006654,
 author = {Iwanaga, T. and Takahashi-Iwanaga, H. and Fujita, T.},
 issue = {1},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Jun},
 note = {GRP (gastrin-releasing peptide)-containing nerves are most densely distributed in the gastric body throughout the gut. We previously found a marked decrease of GRP-immunoreactivity from nerve fibers in the oxyntic mucosa with stress-induced ulcers. The unusual release of GRP from the nerves under stress conditions seems to cause acute mucosal erosions. Since GRP has an action of vasoconstriction which may be responsible for the genesis of ulcers, the present study focuses on the relationship of GRP nerves and blood vessels. The GRP-immunopositive nerves were found to run close to the blood vessels throughout the mucosa. Scanning and transmission electron microscope observations showed that the nerve bundles containing GRP fibers were topographically associated with capillaries, but not with any glandular cells. The oxyntic mucosa is supplied exclusively by capillaries without smooth muscles which may respond to GRP. However, the capillaries here were accompanied by pericytes which reportedly are contractile in nature. Pericytes were frequently found intervening between the capillaries and nerves. The present finding suggests a possibility that GRP released from nerves reduces mucosal blood flow via the contraction of pericytes, finally causing mucosal ischemia and damage.},
 pages = {35--43},
 title = {Possible Mechanism of GRP (Gastrin-Releasing Peptide)-Containing Nerves Regulating the Mucosal Microcirculation in the Rat Gastric Body},
 volume = {37},
 year = {1989}
}