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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.37 No.2

Changes in Human Lymphocyte β-Adrenergic Receptors after Administration of Xamoterol and Atenolol

http://hdl.handle.net/10191/33542
http://hdl.handle.net/10191/33542
4a6e8519-20dc-41ff-a5cf-36f4c72a8040
名前 / ファイル ライセンス アクション
37(2)_85-89.pdf 37(2)_85-89.pdf (925.8 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-10-06
タイトル
タイトル Changes in Human Lymphocyte β-Adrenergic Receptors after Administration of Xamoterol and Atenolol
タイトル
言語 en
タイトル Changes in Human Lymphocyte β-Adrenergic Receptors after Administration of Xamoterol and Atenolol
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 Watanabe, Ken-ishi

× Watanabe, Ken-ishi

WEKO 53806

Watanabe, Ken-ishi

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Hirokawa, Yoichi

× Hirokawa, Yoichi

WEKO 53807

Hirokawa, Yoichi

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Suzuki, Kaoru

× Suzuki, Kaoru

WEKO 53808

Suzuki, Kaoru

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Masani, Fumiaki

× Masani, Fumiaki

WEKO 53809

Masani, Fumiaki

Search repository
Shibata, Akira

× Shibata, Akira

WEKO 53810

Shibata, Akira

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Tsuchihashi, Hiroshi

× Tsuchihashi, Hiroshi

WEKO 53811

Tsuchihashi, Hiroshi

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Nagatomo, Takafumi

× Nagatomo, Takafumi

WEKO 53812

Nagatomo, Takafumi

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抄録
内容記述タイプ Abstract
内容記述 For seven days atenolol (a β-antagonist) and xamoterol (a β-partial agonist) were give orally to healthy volunteers at 50 mg once daily and 100 mg twice daily, respectively. Lymphocyte β-receptor density (Bmax) and affinity (Kd) were determined by radioligand binding assay by using ^<125>I-iodocyanopindolol. Atenolol significantly increased Bmax from 1,566±297 to 3,213±1,134 sites/cell and Kd from 1.12±0.13 to 4.32±2.26 nM. Systolic blood pressure and heart rate were significantly decreased during the treatment with atenolol compared with the basal levels. Xamoterol markedly increased the Bmax and Kd from 1,466±373 and 1.07±0.14 to 7,169±3,768 sites/cell and 6.01±3.84 nM, respectively (p <0.01). But, in contrast to atenolol, the systolic blood pressure increased slightly (p<0.05), and the heart rate was unchanged. Following withdrawal of both drugs, both Bmax and Kd returned to the basal levels. The results indicate that xamoterol up-regulates lymphocyte β-receptors without a decrease in systolic blood pressure, thus suggesting that xamoterol may be beneficial in the treatment of patients with heart failure.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 37, 号 2, p. 85-89, 発行日 1989-09
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
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