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Changes in Human Lymphocyte β-Adrenergic Receptors after Administration of Xamoterol and Atenolol
http://hdl.handle.net/10191/33542
http://hdl.handle.net/10191/335424a6e8519-20dc-41ff-a5cf-36f4c72a8040
名前 / ファイル | ライセンス | アクション |
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37(2)_85-89.pdf (925.8 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2015-10-06 | |||||
タイトル | ||||||
タイトル | Changes in Human Lymphocyte β-Adrenergic Receptors after Administration of Xamoterol and Atenolol | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Changes in Human Lymphocyte β-Adrenergic Receptors after Administration of Xamoterol and Atenolol | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
著者 |
Watanabe, Ken-ishi
× Watanabe, Ken-ishi× Hirokawa, Yoichi× Suzuki, Kaoru× Masani, Fumiaki× Shibata, Akira× Tsuchihashi, Hiroshi× Nagatomo, Takafumi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | For seven days atenolol (a β-antagonist) and xamoterol (a β-partial agonist) were give orally to healthy volunteers at 50 mg once daily and 100 mg twice daily, respectively. Lymphocyte β-receptor density (Bmax) and affinity (Kd) were determined by radioligand binding assay by using ^<125>I-iodocyanopindolol. Atenolol significantly increased Bmax from 1,566±297 to 3,213±1,134 sites/cell and Kd from 1.12±0.13 to 4.32±2.26 nM. Systolic blood pressure and heart rate were significantly decreased during the treatment with atenolol compared with the basal levels. Xamoterol markedly increased the Bmax and Kd from 1,466±373 and 1.07±0.14 to 7,169±3,768 sites/cell and 6.01±3.84 nM, respectively (p <0.01). But, in contrast to atenolol, the systolic blood pressure increased slightly (p<0.05), and the heart rate was unchanged. Following withdrawal of both drugs, both Bmax and Kd returned to the basal levels. The results indicate that xamoterol up-regulates lymphocyte β-receptors without a decrease in systolic blood pressure, thus suggesting that xamoterol may be beneficial in the treatment of patients with heart failure. | |||||
書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 37, 号 2, p. 85-89, 発行日 1989-09 |
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出版者 | ||||||
出版者 | Niigata University School of Medicine | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 05677734 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508361 | |||||
著者版フラグ | ||||||
値 | publisher |