{"_buckets": {"deposit": "be7b1cae-f1dc-4b0c-85d4-37601069e9cb"}, "_deposit": {"id": "6648", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6648"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006648"}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1989-09", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "89", "bibliographicPageStart": "85", "bibliographicVolumeNumber": "37", "bibliographic_titles": [{"bibliographic_title": "Acta medica et biologica"}, {"bibliographic_title": "Acta medica et biologica", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "For seven days atenolol (a \u03b2-antagonist) and xamoterol (a \u03b2-partial agonist) were give orally to healthy volunteers at 50 mg once daily and 100 mg twice daily, respectively. Lymphocyte \u03b2-receptor density (Bmax) and affinity (Kd) were determined by radioligand binding assay by using ^\u003c125\u003eI-iodocyanopindolol. Atenolol significantly increased Bmax from 1,566\u00b1297 to 3,213\u00b11,134 sites/cell and Kd from 1.12\u00b10.13 to 4.32\u00b12.26 nM. Systolic blood pressure and heart rate were significantly decreased during the treatment with atenolol compared with the basal levels. Xamoterol markedly increased the Bmax and Kd from 1,466\u00b1373 and 1.07\u00b10.14 to 7,169\u00b13,768 sites/cell and 6.01\u00b13.84 nM, respectively (p \u003c0.01). But, in contrast to atenolol, the systolic blood pressure increased slightly (p\u003c0.05), and the heart rate was unchanged. Following withdrawal of both drugs, both Bmax and Kd returned to the basal levels. The results indicate that xamoterol up-regulates lymphocyte \u03b2-receptors without a decrease in systolic blood pressure, thus suggesting that xamoterol may be beneficial in the treatment of patients with heart failure.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Niigata University School of Medicine"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508361", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05677734", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Watanabe, Ken-ishi"}], "nameIdentifiers": [{"nameIdentifier": "53806", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hirokawa, Yoichi"}], "nameIdentifiers": [{"nameIdentifier": "53807", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki, Kaoru"}], "nameIdentifiers": [{"nameIdentifier": "53808", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Masani, Fumiaki"}], "nameIdentifiers": [{"nameIdentifier": "53809", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shibata, Akira"}], "nameIdentifiers": [{"nameIdentifier": "53810", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsuchihashi, Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "53811", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nagatomo, Takafumi"}], "nameIdentifiers": [{"nameIdentifier": "53812", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "37(2)_85-89.pdf", "filesize": [{"value": "925.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 925800.0, "url": {"label": "37(2)_85-89.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/6648/files/37(2)_85-89.pdf"}, "version_id": "93e73a76-3cae-43c2-be1c-b95f5e690999"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Changes in Human Lymphocyte \u03b2-Adrenergic Receptors after Administration of Xamoterol and Atenolol", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Changes in Human Lymphocyte \u03b2-Adrenergic Receptors after Administration of Xamoterol and Atenolol"}, {"subitem_title": "Changes in Human Lymphocyte \u03b2-Adrenergic Receptors after Administration of Xamoterol and Atenolol", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/568/649"], "permalink_uri": "http://hdl.handle.net/10191/33542", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2015-10-06"}, "publish_date": "2015-10-06", "publish_status": "0", "recid": "6648", "relation": {}, "relation_version_is_last": true, "title": ["Changes in Human Lymphocyte \u03b2-Adrenergic Receptors after Administration of Xamoterol and Atenolol"], "weko_shared_id": null}