{"created":"2021-03-01T06:10:33.944046+00:00","id":6648,"links":{},"metadata":{"_buckets":{"deposit":"be7b1cae-f1dc-4b0c-85d4-37601069e9cb"},"_deposit":{"id":"6648","owners":[],"pid":{"revision_id":0,"type":"depid","value":"6648"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00006648","sets":["453:456","471:537:568:649"]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1989-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"89","bibliographicPageStart":"85","bibliographicVolumeNumber":"37","bibliographic_titles":[{"bibliographic_title":"Acta medica et biologica"},{"bibliographic_title":"Acta medica et biologica","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"For seven days atenolol (a β-antagonist) and xamoterol (a β-partial agonist) were give orally to healthy volunteers at 50 mg once daily and 100 mg twice daily, respectively. Lymphocyte β-receptor density (Bmax) and affinity (Kd) were determined by radioligand binding assay by using ^<125>I-iodocyanopindolol. Atenolol significantly increased Bmax from 1,566±297 to 3,213±1,134 sites/cell and Kd from 1.12±0.13 to 4.32±2.26 nM. Systolic blood pressure and heart rate were significantly decreased during the treatment with atenolol compared with the basal levels. Xamoterol markedly increased the Bmax and Kd from 1,466±373 and 1.07±0.14 to 7,169±3,768 sites/cell and 6.01±3.84 nM, respectively (p <0.01). But, in contrast to atenolol, the systolic blood pressure increased slightly (p<0.05), and the heart rate was unchanged. Following withdrawal of both drugs, both Bmax and Kd returned to the basal levels. The results indicate that xamoterol up-regulates lymphocyte β-receptors without a decrease in systolic blood pressure, thus suggesting that xamoterol may be beneficial in the treatment of patients with heart failure.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Niigata University School of Medicine"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508361","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05677734","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Watanabe, Ken-ishi"}],"nameIdentifiers":[{"nameIdentifier":"53806","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirokawa, Yoichi"}],"nameIdentifiers":[{"nameIdentifier":"53807","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Kaoru"}],"nameIdentifiers":[{"nameIdentifier":"53808","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masani, Fumiaki"}],"nameIdentifiers":[{"nameIdentifier":"53809","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shibata, Akira"}],"nameIdentifiers":[{"nameIdentifier":"53810","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuchihashi, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"53811","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nagatomo, Takafumi"}],"nameIdentifiers":[{"nameIdentifier":"53812","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"37(2)_85-89.pdf","filesize":[{"value":"925.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"37(2)_85-89.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/6648/files/37(2)_85-89.pdf"},"version_id":"93e73a76-3cae-43c2-be1c-b95f5e690999"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Changes in Human Lymphocyte β-Adrenergic Receptors after Administration of Xamoterol and Atenolol","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Changes in Human Lymphocyte β-Adrenergic Receptors after Administration of Xamoterol and Atenolol"},{"subitem_title":"Changes in Human Lymphocyte β-Adrenergic Receptors after Administration of Xamoterol and Atenolol","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","649"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-10-06"},"publish_date":"2015-10-06","publish_status":"0","recid":"6648","relation_version_is_last":true,"title":["Changes in Human Lymphocyte β-Adrenergic Receptors after Administration of Xamoterol and Atenolol"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:39:59.053546+00:00"}