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Subacute Toxicity of Phenoxy Herbicides, MCPA- and MCPB-Ethylesters, in Mice
http://hdl.handle.net/10191/33483
http://hdl.handle.net/10191/33483b11b9ace-43b5-4bad-bb00-404e7097624d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
38(2)_97-101.pdf (750.7 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2015-10-01 | |||||
| タイトル | ||||||
| タイトル | Subacute Toxicity of Phenoxy Herbicides, MCPA- and MCPB-Ethylesters, in Mice | |||||
| タイトル | ||||||
| タイトル | Subacute Toxicity of Phenoxy Herbicides, MCPA- and MCPB-Ethylesters, in Mice | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
Takagi, Shuko
× Takagi, Shuko× Yamamoto, Masaharu |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Phenoxy herbicides, 2-methyl-4-chlorophenoxyacetic acid ethylester (MCPA-E) and 2-methyl-4-chlorophenoxybutyric acid ethylester (MCPB-E) were evaluated for subacute toxicity by gavage in male mice. Groups of 10 mice were given daily doses of MCPA-E (50, 100 and 200 mg/kg) or MCPB-E (25, 50 and 100 mg/kg) 5 days/wk for 6 weeks. After completion of the treatment, histopathological changes were noted. In addition to this 6-wk experiment, MCPA-E or MCPB-E was given for 12 weeks, and a comparison was made between the two experiments. The relative liver weight of mice in the group treated with MCPA-E for 6 weeks increased significantly. Histopathological changes were seen in the livers of mice at all dose levels of MCPA-E and MCPB-E, both in the 6 and 12-wk experiments. Hepatic cell atypia and central necrosis were the major findings in mice with hepatomegaly. As for the histology of the gallbladder, no specific change was observed in mice treated with MCPA-E and MCPB-E. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 38, 号 2, p. 97-101, 発行日 1990-06 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
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| 値 | publisher | |||||
