@article{oai:niigata-u.repo.nii.ac.jp:00006631,
 author = {Takagi, Shuko and Yamamoto, Masaharu},
 issue = {2},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Jun},
 note = {Phenoxy herbicides, 2-methyl-4-chlorophenoxyacetic acid ethylester (MCPA-E) and 2-methyl-4-chlorophenoxybutyric acid ethylester (MCPB-E) were evaluated for subacute toxicity by gavage in male mice. Groups of 10 mice were given daily doses of MCPA-E (50, 100 and 200 mg/kg) or MCPB-E (25, 50 and 100 mg/kg) 5 days/wk for 6 weeks. After completion of the treatment, histopathological changes were noted. In addition to this 6-wk experiment, MCPA-E or MCPB-E was given for 12 weeks, and a comparison was made between the two experiments. The relative liver weight of mice in the group treated with MCPA-E for 6 weeks increased significantly. Histopathological changes were seen in the livers of mice at all dose levels of MCPA-E and MCPB-E, both in the 6 and 12-wk experiments. Hepatic cell atypia and central necrosis were the major findings in mice with hepatomegaly. As for the histology of the gallbladder, no specific change was observed in mice treated with MCPA-E and MCPB-E.},
 pages = {97--101},
 title = {Subacute Toxicity of Phenoxy Herbicides, MCPA- and MCPB-Ethylesters, in Mice},
 volume = {38},
 year = {1990}
}