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Changes in Cardiac α_1-and β_1-adrenergic Receptors and Ca^<2+> Binding Sites in the Myocardium of SHR
http://hdl.handle.net/10191/33479
http://hdl.handle.net/10191/33479df191387-a834-4bcb-8655-2053adf7882b
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
38(2)_69-74.pdf (903.6 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2015-10-01 | |||||
| タイトル | ||||||
| タイトル | Changes in Cardiac α_1-and β_1-adrenergic Receptors and Ca^<2+> Binding Sites in the Myocardium of SHR | |||||
| タイトル | ||||||
| タイトル | Changes in Cardiac α_1-and β_1-adrenergic Receptors and Ca^<2+> Binding Sites in the Myocardium of SHR | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 著者 |
Watanabe, Kenichi
× Watanabe, Kenichi× Shibata, Akira× Wakabayashi, Hiroyuki× Shimada, Kenji× Tsuchihashi, Hiroshi× Kinami, Junji× Nagatomo, Takafumi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Values of Kd and Bmax in ^3H-prazosin, ^<125>I-iodocyanopindolol and ^3H-nitrendipine bindings to α_1- and β_1-adrenergic receptors and Ca^<2+> binding sites of the myocardium of 2,6, and 16 week-old Wistar Kyoto normotensive Rats (WKY) and spontaneously hypertensive rats (SHR) were compared using a radioligand binding assay method. The catecholamine concentration in the myocardium of both WKY and SHR was also determined. Results obtained as follows: (1) decrease in the Bmax values in α_1- and β_1-adrenoceptors of WKY and SHR during growth was observed; (2) values of Bmax in β_1-adrenoceptors of 16 week-old SHR higher than those of WKY were observed, and in contrast low Kd values of α_1-adrenoceptors in 16 week-old SHRs were observed; (3) no alterations in the Ca^<2+> binding sites in myocardium of both groups were observed during growth and between WKY and SHR; (4) in addition, the increase of norepinephrine concentration in the myocardium of both WKY and SHR during growth was observed and that of 16 week-old SHR was higher than that of WKY. The present study therefore implies that significant high norepinephrine concentration in the myocardium of 16 week-old SHR results in changes in β_1-adrenoceptors binding sites, suggesting that defects of membranes of myocardium of SHR may occur. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 38, 号 2, p. 69-74, 発行日 1990-06 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
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| 値 | publisher | |||||
