{"_buckets": {"deposit": "e40c72bf-1eec-4e6a-9891-8085c851e038"}, "_deposit": {"id": "6627", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6627"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006627"}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1990-06", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "74", "bibliographicPageStart": "69", "bibliographicVolumeNumber": "38", "bibliographic_titles": [{"bibliographic_title": "Acta medica et biologica"}, {"bibliographic_title": "Acta medica et biologica", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Values of Kd and Bmax in ^3H-prazosin, ^\u003c125\u003eI-iodocyanopindolol and ^3H-nitrendipine bindings to \u03b1_1- and \u03b2_1-adrenergic receptors and Ca^\u003c2+\u003e binding sites of the myocardium of 2,6,\u3000and 16 week-old Wistar Kyoto normotensive Rats (WKY) and spontaneously hypertensive rats (SHR) were compared using a radioligand binding assay method. The catecholamine concentration in the myocardium of both WKY and SHR was also determined. Results obtained as follows: (1) decrease in the Bmax values in \u03b1_1- and \u03b2_1-adrenoceptors of WKY and SHR during growth was observed; (2) values of Bmax in \u03b2_1-adrenoceptors of 16 week-old SHR higher than those of WKY were observed, and in contrast low Kd values of \u03b1_1-adrenoceptors in 16 week-old SHRs were\u3000observed; (3) no alterations in the Ca^\u003c2+\u003e binding sites in myocardium of both groups were observed during growth and between WKY and SHR; (4) in addition, the increase of norepinephrine concentration in\u3000the myocardium of both WKY and SHR during growth was observed and that of 16 week-old SHR was higher than that of WKY. The present study therefore implies that significant high norepinephrine\u3000concentration in the myocardium of 16 week-old SHR results in changes in \u03b2_1-adrenoceptors binding sites, suggesting that defects of membranes of myocardium of SHR may occur.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Niigata University School of Medicine"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508361", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05677734", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Watanabe, Kenichi"}], "nameIdentifiers": [{"nameIdentifier": "53728", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shibata, Akira"}], "nameIdentifiers": [{"nameIdentifier": "53729", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Wakabayashi, Hiroyuki"}], "nameIdentifiers": [{"nameIdentifier": "53730", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimada, Kenji"}], "nameIdentifiers": [{"nameIdentifier": "53731", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsuchihashi, Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "53732", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kinami, Junji"}], "nameIdentifiers": [{"nameIdentifier": "53733", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nagatomo, Takafumi"}], "nameIdentifiers": [{"nameIdentifier": "53734", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "38(2)_69-74.pdf", "filesize": [{"value": "903.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 903600.0, "url": {"label": "38(2)_69-74.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/6627/files/38(2)_69-74.pdf"}, "version_id": "ccb9a150-407c-4739-9e1e-d24073e68ad2"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Changes in Cardiac \u03b1_1-and \u03b2_1-adrenergic Receptors and Ca^\u003c2+\u003e Binding Sites in the Myocardium of SHR", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Changes in Cardiac \u03b1_1-and \u03b2_1-adrenergic Receptors and Ca^\u003c2+\u003e Binding Sites in the Myocardium of SHR"}, {"subitem_title": "Changes in Cardiac \u03b1_1-and \u03b2_1-adrenergic Receptors and Ca^\u003c2+\u003e Binding Sites in the Myocardium of SHR", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/568/646"], "permalink_uri": "http://hdl.handle.net/10191/33479", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2015-10-01"}, "publish_date": "2015-10-01", "publish_status": "0", "recid": "6627", "relation": {}, "relation_version_is_last": true, "title": ["Changes in Cardiac \u03b1_1-and \u03b2_1-adrenergic Receptors and Ca^\u003c2+\u003e Binding Sites in the Myocardium of SHR"], "weko_shared_id": null}