{"created":"2021-03-01T06:10:32.612329+00:00","id":6627,"links":{},"metadata":{"_buckets":{"deposit":"e40c72bf-1eec-4e6a-9891-8085c851e038"},"_deposit":{"id":"6627","owners":[],"pid":{"revision_id":0,"type":"depid","value":"6627"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00006627","sets":["453:456","471:537:568:646"]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1990-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"74","bibliographicPageStart":"69","bibliographicVolumeNumber":"38","bibliographic_titles":[{"bibliographic_title":"Acta medica et biologica"},{"bibliographic_title":"Acta medica et biologica","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Values of Kd and Bmax in ^3H-prazosin, ^<125>I-iodocyanopindolol and ^3H-nitrendipine bindings to α_1- and β_1-adrenergic receptors and Ca^<2+> binding sites of the myocardium of 2,6,　and 16 week-old Wistar Kyoto normotensive Rats (WKY) and spontaneously hypertensive rats (SHR) were compared using a radioligand binding assay method. The catecholamine concentration in the myocardium of both WKY and SHR was also determined. Results obtained as follows: (1) decrease in the Bmax values in α_1- and β_1-adrenoceptors of WKY and SHR during growth was observed; (2) values of Bmax in β_1-adrenoceptors of 16 week-old SHR higher than those of WKY were observed, and in contrast low Kd values of α_1-adrenoceptors in 16 week-old SHRs were　observed; (3) no alterations in the Ca^<2+> binding sites in myocardium of both groups were observed during growth and between WKY and SHR; (4) in addition, the increase of norepinephrine concentration in　the myocardium of both WKY and SHR during growth was observed and that of 16 week-old SHR was higher than that of WKY. The present study therefore implies that significant high norepinephrine　concentration in the myocardium of 16 week-old SHR results in changes in β_1-adrenoceptors binding sites, suggesting that defects of membranes of myocardium of SHR may occur.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Niigata University School of Medicine"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508361","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05677734","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Watanabe, Kenichi"}],"nameIdentifiers":[{"nameIdentifier":"53728","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shibata, Akira"}],"nameIdentifiers":[{"nameIdentifier":"53729","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wakabayashi, Hiroyuki"}],"nameIdentifiers":[{"nameIdentifier":"53730","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimada, Kenji"}],"nameIdentifiers":[{"nameIdentifier":"53731","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuchihashi, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"53732","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kinami, Junji"}],"nameIdentifiers":[{"nameIdentifier":"53733","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nagatomo, Takafumi"}],"nameIdentifiers":[{"nameIdentifier":"53734","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"38(2)_69-74.pdf","filesize":[{"value":"903.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"38(2)_69-74.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/6627/files/38(2)_69-74.pdf"},"version_id":"ccb9a150-407c-4739-9e1e-d24073e68ad2"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Changes in Cardiac α_1-and β_1-adrenergic Receptors and Ca^<2+> Binding Sites in the Myocardium of SHR","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Changes in Cardiac α_1-and β_1-adrenergic Receptors and Ca^<2+> Binding Sites in the Myocardium of SHR"},{"subitem_title":"Changes in Cardiac α_1-and β_1-adrenergic Receptors and Ca^<2+> Binding Sites in the Myocardium of SHR","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","646"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-10-01"},"publish_date":"2015-10-01","publish_status":"0","recid":"6627","relation_version_is_last":true,"title":["Changes in Cardiac α_1-and β_1-adrenergic Receptors and Ca^<2+> Binding Sites in the Myocardium of SHR"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:39:56.840655+00:00"}