{"_buckets": {"deposit": "f6defe85-7136-41c3-b009-f6c4393bee58"}, "_deposit": {"id": "6588", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6588"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006588"}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1991-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "167", "bibliographicPageStart": "161", "bibliographicVolumeNumber": "39", "bibliographic_titles": [{"bibliographic_title": "Acta medica et biologica"}, {"bibliographic_title": "Acta medica et biologica", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "We have investigated the effects of Kampohozais (Traditional herbal drugs: Sho-saiko-to \u5c0f\u67f4\u80e1\u6e6f, Ninjin-to \u4eba\u53c2\u6e6f, Hochu-ekki-to \u88dc\u4e2d\u76ca\u6c17\u6e6f,and Juzentaiho-to \u5341\u5168\u5927\u88dc\u6e6f) on immune responses in mice. Ninjin-to augmented the natural killer (NK) cell activity by a single intraperitoneal administration at doses of either 50, 100 or 200 mg/kg. Sho-saiko-to also augmented this activity at a dose of 100 mg/kg, but suppressed it at a dose of 200 mg/kg. An oral administration of Sho-saiko-to and Ninjin-to once a day at a dose of 250 mg/kg augmented the NK cell activity 7 and 20 days later, respectively. The effect of the remaining two Kampohozais was negligible. Four Kampohozais each exhibited a stronger mitogenic activity on B cell-rich population than on T cell-rich population, suggesting that these Kampohozais act as B cell mitogens. Treatment of mice with Sho-saiko-to by oral administration once a day for 13 days at a dose of 250 mg/kg increased the number of splenic antibody-producing cells against sheep erythrocytes, accompanied with an increase in both serum hemagglutinin and hemolysin titers.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Niigata University School of Medicine"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508361", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05677734", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Kaga, Hidetoshi"}], "nameIdentifiers": [{"nameIdentifier": "53591", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ochiai, Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "53592", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kurokawa, Masahiko"}], "nameIdentifiers": [{"nameIdentifier": "53593", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sakuragawa, Nobuo"}], "nameIdentifiers": [{"nameIdentifier": "53594", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "39(4)_161-167.pdf", "filesize": [{"value": "823.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 823100.0, "url": {"label": "39(4)_161-167.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/6588/files/39(4)_161-167.pdf"}, "version_id": "68949b74-1821-4c0c-add0-0c4fed6d428d"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Effects of Kampohozais (Sho-saiko-to, Ninjin-to, Hochu-ekki-to and Juzen-taiho-to) on Immune Responses in Mice", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Effects of Kampohozais (Sho-saiko-to, Ninjin-to, Hochu-ekki-to and Juzen-taiho-to) on Immune Responses in Mice"}, {"subitem_title": "Effects of Kampohozais (Sho-saiko-to, Ninjin-to, Hochu-ekki-to and Juzen-taiho-to) on Immune Responses in Mice", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/568/639"], "permalink_uri": "http://hdl.handle.net/10191/33450", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2015-09-28"}, "publish_date": "2015-09-28", "publish_status": "0", "recid": "6588", "relation": {}, "relation_version_is_last": true, "title": ["Effects of Kampohozais (Sho-saiko-to, Ninjin-to, Hochu-ekki-to and Juzen-taiho-to) on Immune Responses in Mice"], "weko_shared_id": null}