{"created":"2021-03-01T06:10:30.108470+00:00","id":6588,"links":{},"metadata":{"_buckets":{"deposit":"f6defe85-7136-41c3-b009-f6c4393bee58"},"_deposit":{"id":"6588","owners":[],"pid":{"revision_id":0,"type":"depid","value":"6588"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00006588","sets":["453:456","471:537:568:639"]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1991-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"167","bibliographicPageStart":"161","bibliographicVolumeNumber":"39","bibliographic_titles":[{"bibliographic_title":"Acta medica et biologica"},{"bibliographic_title":"Acta medica et biologica","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We have investigated the effects of Kampohozais (Traditional herbal drugs: Sho-saiko-to 小柴胡湯, Ninjin-to 人参湯, Hochu-ekki-to 補中益気湯,and Juzentaiho-to 十全大補湯) on immune responses in mice. Ninjin-to augmented the natural killer (NK) cell activity by a single intraperitoneal administration at doses of either 50, 100 or 200 mg/kg. Sho-saiko-to also augmented this activity at a dose of 100 mg/kg, but suppressed it at a dose of 200 mg/kg. An oral administration of Sho-saiko-to and Ninjin-to once a day at a dose of 250 mg/kg augmented the NK cell activity 7 and 20 days later, respectively. The effect of the remaining two Kampohozais was negligible. Four Kampohozais each exhibited a stronger mitogenic activity on B cell-rich population than on T cell-rich population, suggesting that these Kampohozais act as B cell mitogens. Treatment of mice with Sho-saiko-to by oral administration once a day for 13 days at a dose of 250 mg/kg increased the number of splenic antibody-producing cells against sheep erythrocytes, accompanied with an increase in both serum hemagglutinin and hemolysin titers.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Niigata University School of Medicine"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508361","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05677734","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kaga, Hidetoshi"}],"nameIdentifiers":[{"nameIdentifier":"53591","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ochiai, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"53592","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kurokawa, Masahiko"}],"nameIdentifiers":[{"nameIdentifier":"53593","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakuragawa, Nobuo"}],"nameIdentifiers":[{"nameIdentifier":"53594","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"39(4)_161-167.pdf","filesize":[{"value":"823.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"39(4)_161-167.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/6588/files/39(4)_161-167.pdf"},"version_id":"68949b74-1821-4c0c-add0-0c4fed6d428d"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effects of Kampohozais (Sho-saiko-to, Ninjin-to, Hochu-ekki-to and Juzen-taiho-to) on Immune Responses in Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of Kampohozais (Sho-saiko-to, Ninjin-to, Hochu-ekki-to and Juzen-taiho-to) on Immune Responses in Mice"},{"subitem_title":"Effects of Kampohozais (Sho-saiko-to, Ninjin-to, Hochu-ekki-to and Juzen-taiho-to) on Immune Responses in Mice","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","639"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-09-28"},"publish_date":"2015-09-28","publish_status":"0","recid":"6588","relation_version_is_last":true,"title":["Effects of Kampohozais (Sho-saiko-to, Ninjin-to, Hochu-ekki-to and Juzen-taiho-to) on Immune Responses in Mice"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:39:53.756106+00:00"}