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Participation of Cytokines in Proliferation of Mesangial Cells
http://hdl.handle.net/10191/33465
http://hdl.handle.net/10191/334656755de45-a00c-4a4a-b8f7-f71cac9fbb2f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
39(Suppl.)_87-91.pdf (1.1 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2015-09-28 | |||||
| タイトル | ||||||
| タイトル | Participation of Cytokines in Proliferation of Mesangial Cells | |||||
| タイトル | ||||||
| タイトル | Participation of Cytokines in Proliferation of Mesangial Cells | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 著者 |
Yamamoto, Tadashi
× Yamamoto, Tadashi× Yaoita, Eishin× Kawasaki, Katsutoshi× Kihara, Itaru |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Immunohistochemistry using monoclonal antibody to rat macrophage identified infiltrating macrophages in mesangial cell proliferative glomerular lesions induced by intravenous administration of an antibody against mesangial cell and suggested a role for macrophage-derived cytokines on the proliferation of mesangial cells. Production of tumor necrosis factor (TNF) and interleukin 1 (lL-1) was enhanced in culture medium of the glomeruli isolated from rat kidneys with the mesangial cell proliferative lesions. Further, recombinant TNF, IL-1 and culture medium of lipopoly-saccharide-silica-stimulated rat macrophages promoted a proliferative response in quiescent rat mesangial cells in culture especially when fetal bovine serum was concomitantly present. However, the gel chromatographic profile of the stimulated macrophage culture medium demonstrated a different peak and therefore, different molecular weight of mesangial cell proliferation-promoting activity compared to the peaks of TNF and IL-1 activities. These findings suggested that TNF and IL-1 as well as other factor(s) derived from macrophages enhanced proliferation of mesangial cells in the glomerulus. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 39(Supplement), p. 87-91, 発行日 1991-03 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
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| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
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| 値 | publisher | |||||
