{"_buckets": {"deposit": "ca8b2139-49e2-47ed-8c7c-8e9930d06c8d"}, "_deposit": {"id": "6583", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6583"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006583"}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1991-03", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "91", "bibliographicPageStart": "87", "bibliographicVolumeNumber": "39(Supplement)", "bibliographic_titles": [{"bibliographic_title": "Acta medica et biologica"}, {"bibliographic_title": "Acta medica et biologica", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Immunohistochemistry using monoclonal antibody to rat macrophage identified infiltrating macrophages in mesangial cell proliferative glomerular lesions induced by intravenous administration of an antibody against mesangial cell and suggested a role for macrophage-derived cytokines on the proliferation of mesangial cells. Production of tumor necrosis factor (TNF) and interleukin 1 (lL-1) was enhanced in culture medium of the glomeruli isolated from rat kidneys with the mesangial cell proliferative lesions. Further, recombinant TNF, IL-1 and culture medium of lipopoly-saccharide-silica-stimulated rat macrophages promoted a proliferative response in quiescent rat mesangial cells in culture especially when fetal bovine serum was concomitantly present. However, the gel chromatographic profile of the stimulated macrophage culture medium demonstrated a different peak and therefore, different molecular weight of mesangial cell proliferation-promoting activity compared to the peaks of TNF and IL-1 activities. These findings suggested that TNF and IL-1 as well as other factor(s) derived from macrophages enhanced proliferation of mesangial cells in the glomerulus.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Niigata University School of Medicine"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508361", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05677734", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yamamoto, Tadashi"}], "nameIdentifiers": [{"nameIdentifier": "53564", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yaoita, Eishin"}], "nameIdentifiers": [{"nameIdentifier": "53565", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kawasaki, Katsutoshi"}], "nameIdentifiers": [{"nameIdentifier": "53566", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kihara, Itaru"}], "nameIdentifiers": [{"nameIdentifier": "53567", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "39(Suppl.)_87-91.pdf", "filesize": [{"value": "1.1 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1100000.0, "url": {"label": "39(Suppl.)_87-91.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/6583/files/39(Suppl.)_87-91.pdf"}, "version_id": "e3448b01-859c-492a-8445-89dfdae87caa"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Participation of Cytokines in Proliferation of Mesangial Cells", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Participation of Cytokines in Proliferation of Mesangial Cells"}, {"subitem_title": "Participation of Cytokines in Proliferation of Mesangial Cells", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/568/638"], "permalink_uri": "http://hdl.handle.net/10191/33465", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2015-09-28"}, "publish_date": "2015-09-28", "publish_status": "0", "recid": "6583", "relation": {}, "relation_version_is_last": true, "title": ["Participation of Cytokines in Proliferation of Mesangial Cells"], "weko_shared_id": null}