{"created":"2021-03-01T06:10:29.791703+00:00","id":6583,"links":{},"metadata":{"_buckets":{"deposit":"ca8b2139-49e2-47ed-8c7c-8e9930d06c8d"},"_deposit":{"id":"6583","owners":[],"pid":{"revision_id":0,"type":"depid","value":"6583"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00006583","sets":["453:456","471:537:568:638"]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1991-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"91","bibliographicPageStart":"87","bibliographicVolumeNumber":"39(Supplement)","bibliographic_titles":[{"bibliographic_title":"Acta medica et biologica"},{"bibliographic_title":"Acta medica et biologica","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Immunohistochemistry using monoclonal antibody to rat macrophage identified infiltrating macrophages in mesangial cell proliferative glomerular lesions induced by intravenous administration of an antibody against mesangial cell and suggested a role for macrophage-derived cytokines on the proliferation of mesangial cells. Production of tumor necrosis factor (TNF) and interleukin 1 (lL-1) was enhanced in culture medium of the glomeruli isolated from rat kidneys with the mesangial cell proliferative lesions. Further, recombinant TNF, IL-1 and culture medium of lipopoly-saccharide-silica-stimulated rat macrophages promoted a proliferative response in quiescent rat mesangial cells in culture especially when fetal bovine serum was concomitantly present. However, the gel chromatographic profile of the stimulated macrophage culture medium demonstrated a different peak and therefore, different molecular weight of mesangial cell proliferation-promoting activity compared to the peaks of TNF and IL-1 activities. These findings suggested that TNF and IL-1 as well as other factor(s) derived from macrophages enhanced proliferation of mesangial cells in the glomerulus.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Niigata University School of Medicine"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508361","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05677734","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yamamoto, Tadashi"}],"nameIdentifiers":[{"nameIdentifier":"53564","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yaoita, Eishin"}],"nameIdentifiers":[{"nameIdentifier":"53565","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawasaki, Katsutoshi"}],"nameIdentifiers":[{"nameIdentifier":"53566","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kihara, Itaru"}],"nameIdentifiers":[{"nameIdentifier":"53567","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"39(Suppl.)_87-91.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"39(Suppl.)_87-91.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/6583/files/39(Suppl.)_87-91.pdf"},"version_id":"e3448b01-859c-492a-8445-89dfdae87caa"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Participation of Cytokines in Proliferation of Mesangial Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Participation of Cytokines in Proliferation of Mesangial Cells"},{"subitem_title":"Participation of Cytokines in Proliferation of Mesangial Cells","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","638"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-09-28"},"publish_date":"2015-09-28","publish_status":"0","recid":"6583","relation_version_is_last":true,"title":["Participation of Cytokines in Proliferation of Mesangial Cells"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:39:54.082897+00:00"}