{"_buckets": {"deposit": "290ff249-ec9c-48fa-a49e-001ac31c9242"}, "_deposit": {"id": "6580", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6580"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006580", "sets": ["456", "638"]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1991-03", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "73", "bibliographicPageStart": "67", "bibliographicVolumeNumber": "39(Supplement)", "bibliographic_titles": [{"bibliographic_title": "Acta medica et biologica"}, {"bibliographic_title": "Acta medica et biologica", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "AB-amyloidosis, characterized by the presence of β_2-microglobulin in the amyloid fibrils, has become a major complication of long-term therapy in chronic hemodialysis or peritoneal dialysis patients. The pathogenesis of AB-amyloidosis is incompletely understood, but most likely is based on the uremic retention of β_2-microglobulin. In addition, posttranslational modification of the molecule also seems to be an important step in the amyloidogenesis, since in addition to intact β_2-microglobulin, fragmented β_2-microglobulin or β_2-microglobulin with altered isoelectric properties can be detected in the AB-amyloid fibrils. The occurence of these β_2-microglobulin species could be linked to a chronic intermittent stimulation of monokine release or other subclinical inflammatory processes during renal replacement therapy. Thus, it is possible that, as a consequence of repeated cellular activation, subsequent protease release and/or intracellular processing of β_2-microglobulin occurs. Renal transplantation, though effective in preventing dialysis associated amyloidosis or arresting its progress, does not help to dsistinguish between the relative importance of retention of β_2-microglobulin or inflammatory events. Retrospective studies on AB-amyloid related symptomatology in patients on chronic hemodialysis with synthetic highflux membranes have suggested a lesser prevalence in these patients as compared to patients chronically treated with standard cellulosic membranes. However, a possible benefical effect of chronic treatment with synthetic membranes also might be of multifactorial orgin. To further evaluate this issue and to test whether non-transplant therapies indeed may play a role in the prevention of AB-amyloidosis, prospective studies will be needed. Recently introduced non-invasive scanning methods, employing radiolabelled β_2-microglobulin or amyloid P component, may provide an objective, sensitive and specific basis for such studies.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Niigata University School of Medicine"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508361", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05677734", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Floege, J."}], "nameIdentifiers": [{"nameIdentifier": "53555", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Koch, K. M."}], "nameIdentifiers": [{"nameIdentifier": "53556", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shaldon, S."}], "nameIdentifiers": [{"nameIdentifier": "53557", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "39(Suppl.)_67-73.pdf", "filesize": [{"value": "1.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1200000.0, "url": {"label": "39(Suppl.)_67-73.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/6580/files/39(Suppl.)_67-73.pdf"}, "version_id": "2c12c3dd-0ad3-4aeb-ac43-0c6e1b33bad6"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "AB-Amyloidosis and Monokines", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "AB-Amyloidosis and Monokines"}, {"subitem_title": "AB-Amyloidosis and Monokines", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "638"], "permalink_uri": "http://hdl.handle.net/10191/33462", "pubdate": {"attribute_name": "公開日", "attribute_value": "2015-09-28"}, "publish_date": "2015-09-28", "publish_status": "0", "recid": "6580", "relation": {}, "relation_version_is_last": true, "title": ["AB-Amyloidosis and Monokines"], "weko_shared_id": null}