{"created":"2021-03-01T06:10:29.599686+00:00","id":6580,"links":{},"metadata":{"_buckets":{"deposit":"290ff249-ec9c-48fa-a49e-001ac31c9242"},"_deposit":{"id":"6580","owners":[],"pid":{"revision_id":0,"type":"depid","value":"6580"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00006580","sets":["453:456","471:537:568:638"]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1991-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"73","bibliographicPageStart":"67","bibliographicVolumeNumber":"39(Supplement)","bibliographic_titles":[{"bibliographic_title":"Acta medica et biologica"},{"bibliographic_title":"Acta medica et biologica","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"AB-amyloidosis, characterized by the presence of β_2-microglobulin in the amyloid fibrils, has become a major complication of long-term therapy in chronic hemodialysis or peritoneal dialysis patients. The pathogenesis of AB-amyloidosis is incompletely understood, but most likely is based on the uremic retention of β_2-microglobulin. In addition, posttranslational modification of the molecule also seems to be an important step in the amyloidogenesis, since in addition to intact β_2-microglobulin, fragmented β_2-microglobulin or β_2-microglobulin with altered isoelectric properties can be detected in the AB-amyloid fibrils. The occurence of these β_2-microglobulin species could be linked to a chronic intermittent stimulation of monokine release or other subclinical inflammatory processes during renal replacement therapy. Thus, it is possible that, as a consequence of repeated cellular activation, subsequent protease release and/or intracellular processing of β_2-microglobulin occurs. Renal transplantation, though effective in preventing dialysis associated amyloidosis or arresting its progress, does not help to dsistinguish between the relative importance of retention of β_2-microglobulin or inflammatory events. Retrospective studies on AB-amyloid related symptomatology in patients on chronic hemodialysis with synthetic highflux membranes have suggested a lesser prevalence in these patients as compared to patients chronically treated with standard cellulosic membranes. However, a possible benefical effect of chronic treatment with synthetic membranes also might be of multifactorial orgin. To further evaluate this issue and to test whether non-transplant therapies indeed may play a role in the prevention of AB-amyloidosis, prospective studies will be needed. Recently introduced non-invasive scanning methods, employing radiolabelled β_2-microglobulin or amyloid P component, may provide an objective, sensitive and specific basis for such studies.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Niigata University School of Medicine"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508361","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05677734","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Floege, J."}],"nameIdentifiers":[{"nameIdentifier":"53555","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Koch, K. M."}],"nameIdentifiers":[{"nameIdentifier":"53556","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shaldon, S."}],"nameIdentifiers":[{"nameIdentifier":"53557","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"39(Suppl.)_67-73.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"39(Suppl.)_67-73.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/6580/files/39(Suppl.)_67-73.pdf"},"version_id":"2c12c3dd-0ad3-4aeb-ac43-0c6e1b33bad6"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"AB-Amyloidosis and Monokines","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"AB-Amyloidosis and Monokines"},{"subitem_title":"AB-Amyloidosis and Monokines","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","638"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-09-28"},"publish_date":"2015-09-28","publish_status":"0","recid":"6580","relation_version_is_last":true,"title":["AB-Amyloidosis and Monokines"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:39:54.003071+00:00"}